Search Results - "Pawelec, Graham"

Age and immunity: What is “immunosenescence”? by Pawelec, Graham

“…As is apparent from the many contributions to this Special Issue of the Journal, the impact of age on immunity is nefarious, with all manner of dysregulated…”
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Hallmarks of human "immunosenescence": adaptation or dysregulation? by Pawelec, Graham

“…Is immunosenescence an intrinsic ageing process leading to dysregulation of immunity or an adaptive response of the individual to pathogen exposure?…”
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Is There a Positive Side to T Cell Exhaustion? by Pawelec, Graham

“…T cell "exhaustion" describes a state of late-stage differentiation usually associated with active prevention of functionality via ligation of negative…”
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Does immunosenescence drive organismal ageing via inflammageing? by Pawelec, Graham

“…[...]strikingly, p16 and p21 expression was higher in many non-immune tissues of animals deficient for Ercc1 only in cells derived from HSCs, resulting in…”
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Multiple thymi and no thymic involution in naked mole rats? by Pawelec, Graham

“…[...]there has been a great deal of interest in preventing or reversing thymic involution in order to maintain diversity of the naïve TCR repertoire, required…”
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Latent CMV makes older adults less naïve by Pawelec, Graham

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Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer by Picard, Emilie, Verschoor, Chris P, Ma, Grace W, Pawelec, Graham

“…Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which has major repercussions on the efficacy of immunotherapy. A small…”
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Twenty-five Years at the Frontiers of Knowledge: A Quarter-century of “Frontiers in Bioscience” by Pawelec, Graham

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Does the human immune system ever really become "senescent"? [version 1; peer review: 5 approved] by Pawelec, Graham

“…Like all somatic tissues, the human immune system changes with age. This is believed to result in an increased frequency of, and susceptibility to, infectious…”
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Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions by Di Benedetto, Svetlana, Müller, Ludmila, Wenger, Elisabeth, Düzel, Sandra, Pawelec, Graham

“…[Display omitted] •Central nervous and immune systems interact constantly through multiple pathways.•Peripheral immunosenescence and “inflammaging” may…”
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Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity by Pawelec, Graham, Verschoor, Chris P, Ostrand-Rosenberg, Suzanne

“…Since the realization that immature myeloid cells are powerful modulators of the immune response, many studies on "myeloid-derived suppressor cells" (MDSCs)…”
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CASIN the joint: immune aging at the stem cell level by Pawelec, Graham P.

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Invited Editorial: Despite COVID-19, Influenza Must Not Be Relegated to “Only the Sniffles” by Pawelec, Graham

“…As the current COVID-19 pandemic continues to rage worldwide, it has emerged that the 2019–2020 influenza season has been milder and shorter than usual in the…”
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T-cell immunity in the aging human by Pawelec, Graham

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Unanticipated efficacy of SARS-CoV-2 vaccination in older adults by Pawelec, Graham, McElhaney, Janet

“…The rapidity with which vaccines against COVID-19 have been developed and tested is unprecedented. As classically the case with randomized clinical trials,…”
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Can an effective SARS-CoV-2 vaccine be developed for the older population? by Pawelec, Graham, Weng, Nan-Ping

“…The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems…”
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Role of the peripheral innate immune system in the development of Alzheimer's disease by Le Page, Aurélie, Dupuis, Gilles, Frost, Eric H., Larbi, Anis, Pawelec, Graham, Witkowski, Jacek M., Fulop, Tamas

“…Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists…”
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Cytomegalovirus and human immunosenescence by Pawelec, Graham, Derhovanessian, Evelyna, Larbi, Anis, Strindhall, Jan, Wikby, Anders

“…‘Immunosenescence’ is an imprecise term used to describe deleterious age‐associated changes to immune parameters observed in all mammals studied so far…”
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Editorial: Immunology of Aging by Pawelec, Graham, Gupta, Sudhir

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Human endogenous retroviruses and ageing by Hurme, Mikko, Pawelec, Graham

“…[...]studies demonstrating associations between HERV expression and a given disease condition would be more informative if the location of the provirus, and…”
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