Search Results - "Pawełczak, Małgorzata"

Dipeptide analogues of fluorinated aminophosphonic acid sodium salts as moderate competitive inhibitors of cathepsin C by Wątroba, Karolina, Pawełczak, Małgorzata, Kaźmierczak, Marcin

“…In this paper, we present the solvolysis reaction of dipeptide analogues of fluorinated aminophosphonates with simultaneous quantitative deprotection of the…”
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Purification and partial characterization of aminopeptidase from barley (Hordeum vulgare L.) seeds by Oszywa, Bartosz, Makowski, Maciej, Pawełczak, Małgorzata

“…Aminopeptidases (EC 3.4.11) are proteolytic enzymes, which hydrolyze one amino acid from N-terminus of peptidic substrates. Inhibitors of plant aminopeptidases…”
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N -Benzyl Residues as the P1' Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases by Janiszewska, Kamila, Talma, Michał, Oszywa, Bartosz, Pawełczak, Małgorzata, Kafarski, Paweł, Mucha, Artur

“…Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH -NH) can be termed extended transition state analogs by…”
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Phosphinotripeptidic Inhibitors of Leucylaminopeptidases by Jewgiński, Michał, Haremza, Kinga, de los Santos, Jesús M., Es Sbai, Zouhair, Oszywa, Bartosz, Pawełczak, Małgorzata, Palacios, Francisco, Latajka, Rafał

“…Phosphinate pseudopeptide are analogs of peptides containing phosphinate moiety in a place of the amide bond. Due to this, the organophosphorus fragment…”
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Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases by Vassiliou, Stamatia, Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Mulligan, Rory, Joachimiak, Andrzej, Mucha, Artur

“…Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus…”
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Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds by Wanat, Weronika, Talma, Michał, Pawełczak, Małgorzata, Kafarski, Paweł

“…The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and…”
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Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes by Wanat, Weronika, Talma, Michał, Hurek, Józef, Pawełczak, Małgorzata, Kafarski, Paweł

“…A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity…”
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A structural insight into the P1 S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases by Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur

“…N'-substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected…”
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Synthesis of Hybrid Tripeptide Peptidomimetics Containing Dehydroamino Acid and Aminophosphonic Acid in the Chain and Evaluation of Their Activity toward Cathepsin C by Jewgiński, Michał Paweł, Makowski, Maciej, Pawełczak, Małgorzata, Goldeman, Waldemar, Trojanowska‐Laskowska, Alicja, Kafarski, Paweł, Latajka, Rafał

“…Synthesis of a new group of hybrid phosphonodehydropeptides composed of glycyl‐(Z)‐dehydrophenylalanine and structurally variable aminophosphonates alongside…”
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Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C by Lenartowicz, Paweł, Makowski, Maciej, Oszywa, Bartosz, Haremza, Kinga, Latajka, Rafał, Pawełczak, Małgorzata, Kafarski, Paweł

“…Addition of thiols to double bond of glycyl-dehydroalanine and phenyl-dehydroalanine esters provided micromolar inhibitors of cathepsin C. The…”
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A three-component Mannich-type condensation leading to phosphinic dipeptides—extended transition state analogue inhibitors of aminopeptidases by Dziełak, Anna, Pawełczak, Małgorzata, Mucha, Artur

“…N-Protected α-aminoalkylphosphinic acids bearing a P–H function were found to be novel practical building blocks in three-component condensations with…”
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Substrate specificity screening of oat (Avena sativa) seeds aminopeptidase demonstrate unusually broad tolerance in S1 pocket by Gajda, Anna D., Pawełczak, Małgorzata, Drag, Marcin

“…Aminopeptidases are proteolytic enzymes that remove one amino acid at a time from N-terminus of peptidic substrates. In plants, inhibitors of aminopeptidases…”
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influence of α-aminophosphonic acids on the activity of aminopeptidase from barley seeds—an approach to determine the enzyme specificity by Oszywa, Bartosz, Pawełczak, Małgorzata, Kafarski, Paweł

“…Inhibitory potencies of 24 α-aminophosphonic acids against barley seeds (Hordeum vulgare L.) metallo-aminopeptidase have been determined to evaluate structural…”
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Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides by Drąg, Marcin, Wieczerzak, Ewa, Pawełczak, Małgorzata, Berlicki, Łukasz, Grzonka, Zbigniew, Kafarski, Paweł

“…Cathepsins play an important role in several human disorders and therefore the design and synthesis of their inhibitors attracts considerable interest in…”
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Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase by Mucha, Artur, Lämmerhofer, Michael, Lindner, Wolfgang, Pawełczak, Małgorzata, Kafarski, Paweł

“…First successful separation of all four stereoisomers of a phosphinic acid pseudodipeptide allowed to determine the inhibitory activity of the…”
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Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C by Makowski, Maciej, Lenartowicz, Paweł, Oszywa, Bartosz, Jewgiński, Michał, Pawełczak, Małgorzata, Kafarski, Paweł

“…The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These…”
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A synthetic method for diversification of the P1′ substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1′ binding pockets of leucine aminopeptidases by Vassiliou, Stamatia, Xeilari, Metaxia, Yiotakis, Athanasios, Grembecka, Jolanta, Pawełczak, Małgorzata, Kafarski, Paweł, Mucha, Artur

“…A novel, general, and versatile method of diversification of the P1′ position in phosphinic pseudodipeptides, presumable inhibitors of proteolytic enzymes, was…”
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Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine by Pícha, Jan, Liboska, Radek, Buděšínský, Miloš, Jiráček, Jiři, Pawełczak, Małgorzata, Mucha, Artur

“…Ligands containing bulky aliphatic P1 residues exhibit a high affinity towards cytosolic leucine aminopeptidase, a bizinc protease of biomedical significance…”
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Synthesis of Tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity by Makowski, Maciej, Pawełczak, Małgorzata, Latajka, Rafał, Nowak, Kornel, Kafarski, Paweł

“…Three dehydrotetrapeptides of rationally varying structure were prepared and tested as affectors of cathepsin C. These compounds appeared to be substrates of…”
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A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases by Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur

“…N′-substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected…”
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