Search Results - "Pavlov, Evgeny V"

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase by Esteras, Noemi, Kundel, Franziska, Amodeo, Giuseppe F., Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y.

“…Most neurodegenerative disorders are associated with aggregation and accumulation of misfolded proteins. One of these proteins, tau, is involved in a number of…”
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease by Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions,…”
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ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore by Neginskaya, Maria A., Solesio, Maria E., Berezhnaya, Elena V., Amodeo, Giuseppe F., Mnatsakanyan, Nelli, Jonas, Elizabeth A., Pavlov, Evgeny V.

“…Permeability transition (PT) is an increase in mitochondrial inner membrane permeability that can lead to a disruption of mitochondrial function and cell…”
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation by Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that…”
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Investigation of Properties of the Mitochondrial Permeability Transition Pore Using Whole-Mitoplast Patch-Clamp Technique by Neginskaya, Maria A, Pavlov, Evgeny V

“…The mitochondrial permeability transition pore (mPTP) is a channel in the mitochondrial inner membrane that is activated by excessive calcium uptake. In this…”
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Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate by Seidlmayer, Lea K, Juettner, Vanessa V, Kettlewell, Sarah, Pavlov, Evgeny V, Blatter, Lothar A, Dedkova, Elena N

“…The mitochondrial permeability transition pore (mPTP) plays a central role for tissue damage and cell death during ischaemia-reperfusion (I/R). We investigated…”
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The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function by Strubbe-Rivera, Jasiel O., Schrad, Jason R., Pavlov, Evgeny V., Conway, James F., Parent, Kristin N., Bazil, Jason N.

“…Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain…”
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Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors by Nichols, Matthew, Elustondo, Pia A, Warford, Jordan, Thirumaran, Aruloli, Pavlov, Evgeny V, Robertson, George S

“…The effects of global mitochondrial calcium (Ca2+) uniporter (MCU) deficiency on hypoxic-ischemic (HI) brain injury, neuronal Ca2+ handling, bioenergetics and…”
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Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D by Amodeo, Giuseppe Federico, Krilyuk, Natalya, Pavlov, Evgeny V

“…The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c…”
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C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition by Amodeo, Giuseppe Federico, Lee, Brenda Yasie, Krilyuk, Natalya, Filice, Carina Teresa, Valyuk, Denis, Otzen, Daniel Erik, Noskov, Sergey, Leonenko, Zoya, Pavlov, Evgeny V.

“…The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral part of the F 0 complex of the ATP…”
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Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation by Seidlmayer, Lea K., Gomez-Garcia, Maria R., Shiba, Toshikazu, Porter, George A., Pavlov, Evgeny V., Bers, Donald M., Dedkova, Elena N.

“…We have previously demonstrated that inorganic polyphosphate (polyP) is a potent activator of the mitochondrial permeability transition pore (mPTP) in cardiac…”
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Mitochondrial Cyclosporine A-Independent Palmitate/Ca2+-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity by Mironova, Galina D., Pavlov, Evgeny V.

“…A sharp increase in the permeability of the mitochondrial inner membrane known as mitochondrial permeability transition (or mPT) occurs in mitochondria under…”
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TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors by Mohandass, Adithya, Krishnan, Vivek, Gribkova, Ekaterina D., Asuthkar, Swapna, Baskaran, Padmamalini, Nersesyan, Yelena, Hussain, Zahir, Wise, Leslie M., George, Robert E., Stokes, Nadarra, Alexander, Brenda M., Cohen, Alejandro M., Pavlov, Evgeny V., Llano, Daniel A., Zhu, Michael X., Thyagarajan, Baskaran, Zakharian, Eleonora

“…Testosterone regulates dimorphic sexual behaviors in all vertebrates. However, the molecular mechanism underlying these behaviors remains unclear. Here, we…”
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Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice by Liu, Zhongbo, Solesio, Maria E, Schaffler, Mitchell B, Frikha‐Benayed, Dorra, Rosen, Clifford J, Werner, Haim, Kopchick, John J, Pavlov, Evgeny V, Abramov, Andrey Y, Yakar, Shoshana

“…ABSTRACT Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRKO) mice exhibit severe skeletal impairment. The…”
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Refractive Index Imaging Reveals That Elimination of the ATP Synthase C Subunit Does Not Prevent the Adenine Nucleotide Translocase-Dependent Mitochondrial Permeability Transition by Neginskaya, Maria A, Morris, Sally E, Pavlov, Evgeny V

“…The mitochondrial permeability transition pore (mPTP) is a large, weakly selective pore that opens in the mitochondrial inner membrane in response to the…”
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Osmotic regulation of the mitochondrial permeability transition pore investigated by light scattering, fluorescence and electron microscopy techniques by Baev, Artyom Y., Elustondo, Pia A., Negoda, Alexander, Pavlov, Evgeny V.

“…Mitochondrial permeability transition (PT) is a phenomenon of an increase of the inner membrane permeability in response to an excessive matrix calcium…”
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Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore by Solesio, Maria E, Elustondo, Pia A, Zakharian, Eleonora, Pavlov, Evgeny V

“…Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological…”
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Effects of lithium isotopes on sodium/lithium co-transport and calcium efflux through the sodium/calcium/lithium exchanger in mitochondria by Bukhteeva, Irina, Rahman, Fasih A, Kendall, Brian, Duncan, Robin E, Quadrilatero, Joe, Pavlov, Evgeny V, Gingras, Michel J P, Leonenko, Zoya

“…The effects of lithium (Li) isotopes and their impact on biological processes have recently gained increased attention due to the significance of Li as a…”
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From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore by Amodeo, Giuseppe Federico, Solesio, Maria E., Pavlov, Evgeny V.

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In Situ Investigation of Mammalian Inorganic Polyphosphate Localization Using Novel Selective Fluorescent Probes JC-D7 and JC-D8 by Angelova, Plamena R, Agrawalla, Bikram Keshari, Elustondo, Pia A, Gordon, Jacob, Shiba, Toshikazu, Abramov, Andrey Y, Chang, Young-Tae, Pavlov, Evgeny V

“…Inorganic polyphosphate (polyP) is a polymer composed of many orthophosphates linked together by phosphoanhydride bonds. Recent studies demonstrate that in…”
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