Search Results - "Pavliak, Viliam"
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Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
Published in mSphere (25-09-2019)“…Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience…”
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Development and Validation of 13-plex Luminex-Based Assay for Measuring Human Serum Antibodies to Streptococcus pneumoniae Capsular Polysaccharides
Published in mSphere (08-08-2018)“…A Luminex-based direct immunoassay (dLIA) platform has been developed to replace the standardized pneumococcal enzyme-linked immunosorbent assay platform. The…”
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O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide
Published in Human vaccines & immunotherapeutics (02-01-2018)“…Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial…”
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Structure elucidation of capsular polysaccharides from Streptococcus pneumoniae serotype 33C, 33D, and revised structure of serotype 33B
Published in Carbohydrate research (13-01-2014)“…•Serotype 33B and 33D have nearly identical repeat units with a one residue difference.•Serotype 33C is structurally more similar to the 33B/33D than to the…”
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Identification of the common antigenic determinant shared by Streptococcus pneumoniae serotypes 33A, 35A, and 20 capsular polysaccharides
Published in Carbohydrate research (18-10-2013)“…•Serotype 33A polysaccharide has the same backbone structure as serotype 33F.•Serotype 33A has two additional sites of O-acetylation compared to 33F.•The…”
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NMR structural analysis of the capsular polysaccharide from Streptococcus pneumoniae serotype 6C
Published in Carbohydrate research (01-04-2012)“…The original structure of Streptococcus pneumoniae capsular polysaccharide (CPS) serotype 6C was proposed based on chemical degradation and tandem mass…”
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Structural studies of mannans from the cell walls of the pathogenic yeasts Candida albicans serotypes A and B and Candida parapsilosis
Published in Carbohydrate research (01-02-1988)“…A comparative study of three cell-wall mannans, of Candida albicans serotypes A and B and Candida parapsilosis, by means of methylation analysis supports a…”
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Heterogeneous in vivo expression of clumping factor A and capsular polysaccharide by Staphylococcus aureus : Implications for vaccine design
Published in Vaccine (26-05-2009)“…Abstract There is a clear unmet medical need for a vaccine that would prevent infections from Staphylococcus aureus ( S. aureus ). To validate antigens as…”
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Journal Article Conference Proceeding -
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Development and Validation of 13-plex Luminex-Based Assay for Measuring Human Serum Antibodies to italic toggle="yes">Streptococcus pneumoniae /italic> Capsular Polysaccharides
Published in mSphere (01-08-2018)“…ABSTRACT A Luminex-based direct immunoassay (dLIA) platform has been developed to replace the standardized pneumococcal enzyme-linked immunosorbent assay…”
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Journal Article -
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NMR structural analysis of the capsular polysaccharide from Streptococcuspneumoniae serotype 6C
Published in Carbohydrate research (01-04-2012)“…[Display omitted] ► The repeat unit structure of serotype 6C is established by various NMR spectra study. ► 2D-NMR studies led to full 1H and 13C NMR spectra…”
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Structural elucidation of the capsular polysaccharide of Bacteroides fragilis strain 23745M1
Published in Carbohydrate research (02-10-1995)“…The capsule of Bacteroides fragilis (ATCC23745) consists of two distinct polysaccharides, the separation of which could not be accomplished. The mouse-passaged…”
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Novel structure of the cellular mannan of the pathogenic yeast Candida krusei
Published in Carbohydrate research (31-12-1988)“…On the basis of methylation analysis, 13C- and 1H-n.m.r. spectroscopic data, and the results of immunological methods, a new structure for the cell-wall…”
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Heterogeneousin vivoexpression of clumping factor A and capsular polysaccharide byStaphylococcus aureus: Implications for vaccine design
Published in Vaccine (26-05-2009)“…There is a clear unmet medical need for a vaccine that would prevent infections fromStaphylococcus aureus(S. aureus). To validate antigens as potential vaccine…”
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Journal Article -
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Phase-variation of the truncated lipo-oligosaccharide of Neisseria meningitidis NMB phosphoglucomutase isogenic mutant NMB-R6
Published in Carbohydrate research (21-11-2003)“…The detection of antibodies specific to meningococcal lipo-oligosaccharides (LOSs; outer-core→inner-core→lipid A) in sera of patients convalescent from…”
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Journal Article -
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Structure of the sialylated L3 lipopolysaccharide of Neisseria meningitidis
Published in The Journal of biological chemistry (05-07-1993)“…The L3 immunotype lipopolysaccharide (LPS) of Neisseria meningitidis was subjected to degradation procedures, which produced a number of different…”
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O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide
Published in Human Vaccines & Immunotherapeutics (02-01-2018)“…Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial…”
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Characterization of colominic acid by circular dichroism and viscosity analysis
Published in Biophysical chemistry (31-01-1997)“…Conformations of oligo- and poly-(α(2 → 8)- D-Neu pNAc) (colominic acid) and its derivatives were studied by circular dichroism (CD) spectroscopy and…”
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Journal Article -
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Binding of the O-antigen of Shigella dysenteriae type 1 and 26 related synthetic fragments to a monoclonal IgM antibody
Published in The Journal of biological chemistry (05-12-1993)“…Shigella dysenteriae type 1 possesses an O-antigen whose repeating unit is –>3)-alpha-L-Rhap-(1–>3)-alpha-L-Rhap-(1–>2)-alpha-D-Galp -(1–>3)-alpha-D-…”
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Capsular polysaccharide-protein conjugate vaccines
Published in Drug discovery today (1996)“…The conjugation of polysaccharides to carrier proteins generally enhances polysaccharide immunogenicity and renders the immune response T-cell dependent. Such…”
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