Search Results - "Paviani, Veronica"

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch by Palma, Flavio R, He, Chenxia, Danes, Jeanne M, Paviani, Veronica, Coelho, Diego R, Gantner, Benjamin N, Bonini, Marcelo G

“…Reactive oxygen species (ROS) are now widely recognized as central mediators of cell signaling. Mitochondria are major sources of ROS. It is now clear that…”
Get more information

Production of lysozyme and lysozyme-superoxide dismutase dimers bound by a ditryptophan cross-link in carbonate radical-treated lysozyme by Paviani, Verônica, Queiroz, Raphael F., Marques, Emerson F., Di Mascio, Paolo, Augusto, Ohara

“…Despite extensive investigation of the irreversible oxidations undergone by proteins in vitro and in vivo, the products formed from the oxidation of Trp…”
Get full text

AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism by Palma, Flavio R., Ratti, Bianca A., Paviani, Veronica, Coelho, Diego R., Miguel, Rodrigo, Danes, Jeanne M., Zaichik, Sofia V., de Abreu, Andre L., Silva, Sueli O., Chen, Yiliang, Silverstein, Roy L., Karan, Uppal, Jones, Dean P., Bonini, Marcelo G.

“…Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for the…”
Get full text

SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes by Coelho, Diego R., Palma, Flavio R., Paviani, Veronica, LaFond, Katy M., Huang, Yunping, Wang, Dongmei, Wray, Brian, Rao, Sridhar, Yue, Feng, Bonini, Marcelo G., Gantner, Benjamin N.

“…Suppressor of cytokine signaling-1 (SOCS1) exerts control over inflammation by targeting p65 nuclear factor-κB (NF-κB) for degradation in addition to its…”
Get full text

The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol by Queiroz, Raphael F, Paviani, Verônica, Coelho, Fernando R, Marques, Emerson F, Di Mascio, Paolo, Augusto, Ohara

“…Tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl) reduces tissue injury in animal models of various diseases via mechanisms that are not completely…”
Get more information

Human cataractous lenses contain cross-links produced by crystallin-derived tryptophanyl and tyrosyl radicals by Paviani, Verônica, Junqueira de Melo, Paulo, Avakin, Amaryllis, Di Mascio, Paolo, Ronsein, Graziella Eliza, Augusto, Ohara

“…Protein insolubilization, cross-linking and aggregation are considered critical to the development of lens opacity in cataract. However, the information about…”
Get full text

Ditryptophan Cross-Links as Novel Products of Protein Oxidation by Paviani, Verônica, Galdino, Gabriel, dos Prazeres, Janaina, Queiroz, Raphael, Augusto, Ohara

“…Protein oxidation is an unavoidable consequence of aerobic metabolism. The oxidation of most proteins residues is non-repairable and may affect protein…”
Get full text

NOS1-Derived Nitric Oxide Regulates NFκB Target Specificity and Macrophage Inflammatory Polarization by Coelho, Diego, Sampaio, Veronica Paviani, Gantner, Benjamin, Bonini, Marcelo

Get full text

The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1 by Truzzi, Daniela R., Coelho, Fernando R., Paviani, Veronica, Alves, Simone V., Netto, Luis E.S., Augusto, Ohara

“…2-Cys peroxiredoxins (Prxs) rapidly reduce H2O2, thereby acting as antioxidants and also as sensors and transmitters of H2O2 signals in cells. Interestingly,…”
Get full text

Human cataracts contain cross-links produced from crystallin-derived tryptophanyl and tyrosyl radicals by Sampaio, Veronica Paviani, Junqueira de Melo, Paulo, Ronsein, Graziella Eliza, Avakian, Amaryllis, Di Mascio, Paolo, Augusto, Ohara

Get full text

Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity by Coelho, Diego R, Palma, Flavio R, Paviani, Veronica, He, Chenxia, Danes, Jeanne M, Huang, Yunping, Calado, Juliana C P, Hart, Peter C, Furdui, Cristina M, Poole, Leslie B, Schipma, Matthew J, Bonini, Marcelo G

“…The dichotomous behavior of superoxide dismutase-2 (SOD2) in cancer biology has long been acknowledged and more recently linked to different posttranslational…”
Get full text

P-87 - Ditryptophan cross-links are detected in bovine beta crystallin irradiated with a solar simulator and in human lenses with advanced cataract by Paviani, Veronica, Junqueira de Melo, Paulo, Rosein, Graziela, Avakin, Amaryllis, Augusto, Ohara

“…We first showed the formation of a ditryptophan (Trp-Trp) cross-link through recombination of human superoxide dismutase-tryptophanyl radicals in 2010. This…”
Get full text

Ditryptophan cross-links are detected in bovine beta crystallin irradiated with a solar simulator and in human lenses with advanced cataract by Paviani, Veronica, Junqueira de Melo, Paulo, Rosein, Graziela, Avakin, Amaryllis, Augusto, Ohara

Get full text

OP-24 - Bicarbonate increases peroxiredoxin 1 susceptibility to hyperoxidation by Truzzi, Daniela R, Coelho, Fernando R, Paviani, Veronica, Alves, Simone V, Netto, Luis ES, Augusto, Ohara

“…Peroxiredoxins (Prx) are abundant thiol peroxidases that react rapidly with H2O2, constituting an important antioxidant defense and acting as sensors and…”
Get full text

Bicarbonate increases peroxiredoxin 1 susceptibility to hyperoxidation by Truzzi, Daniela R, Coelho, Fernando R, Paviani, Veronica, Alves, Simone V, Netto, Luis ES, Augusto, Ohara

Get full text

Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase by Iqbal, Asif, Paviani, Veronica, Moretti, Ana Iochabel, Laurindo, Francisco R.M., Augusto, Ohara

“…[Display omitted] •PDI was challenged with the bicarbonate-dependent peroxidase activity of hSOD1.•The challenge resulted in PDI oxidation, inactivation and…”
Get full text

388 - MS Characterization of the Ditryptophan Cross-Links in Lysozyme Submitted to Enzymatically and Photolytically Generated Carbonate Radicals by Paviani, Veronica, Queiroz, Raphael Ferreira, Marquez, Emerson Finco, Di Mascio, Paolo, Augusto, Ohara

Get full text

MS Characterization of the Ditryptophan Cross-Links in Lysozyme Submitted to Enzymatically and Photolytically Generated Carbonate Radicals by Paviani, Veronica, Queiroz, Raphael Ferreira, Marquez, Emerson Finco, Di Mascio, Paolo, Augusto, Ohara

Get full text

PSS201 - The Carbonylation and Covalent Dimerization of hSOD1 Caused by Its Bicarbonate-Dependent Peroxidase Activity Is Inhibited by Tempol by Ferreira Queiroz, Raphael, Paviani, Veronica, Rodrigues Coelho, Fernando, Finco Marques, Emerson, Di Mascio, Paolo, Augusto, Ohara

Get full text

The Carbonylation and Covalent Dimerization of hSOD1 Caused by Its Bicarbonate-Dependent Peroxidase Activity Is Inhibited by Tempol by Ferreira Queiroz, Raphael, Paviani, Veronica, Rodrigues Coelho, Fernando, Finco Marques, Emerson, Di Mascio, Paolo, Augusto, Ohara

Get full text