Search Results - "Pavey, Nathan"

Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis by Hannaford, Andrew, Pavey, Nathan, Bos, Mehdi, Geevasinga, Nimeshan, Menon, Parvathi, Shefner, Jeremy M., Kiernan, Matthew C., Vucic, Steve

“…Objective The diagnosis of amyotrophic lateral sclerosis (ALS) remains problematic, with current diagnostic criteria (revised El Escorial [rEEC] and Awaji)…”
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Abnormalities of cortical stimulation strength-duration time constant in amyotrophic lateral sclerosis by Pavey, Nathan A., Menon, Parvathi, Peterchev, Angel V., Kiernan, Matthew C., Vucic, Steve

“…•Strength-duration time constant (SDTC) may now be determined for cortical motor neurones.•SDTC is significantly reduced in ALS patients and is correlated with…”
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Cortical hyperexcitability: Diagnostic and pathogenic biomarker of ALS by Vucic, Steve, Pavey, Nathan, Haidar, Mouna, Turner, Bradley J., Kiernan, Matthew C.

“…•Cortical hyperexcitability is an important pathophysiological mechanism in ALS.•Cortical hyperexcitability is a diagnostic tool in early stages of…”
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Reproducibility of motor unit number index and MScanFit motor unit number estimation across intrinsic hand muscles by Higashihara, Mana, Menon, Parvathi, Bos, Mehdi, Pavey, Nathan, Vucic, Steve

“…Introduction We sought to evaluate the reproducibility of the motor unit number index (MUNIX) and MScanFit motor unit number estimation (MScan) when recording…”
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Split-hand index: A diagnostic and prognostic marker in amyotrophic lateral sclerosis across varying regions of onset by Hannaford, Andrew, Higashihara, Mana, Pavey, Nathan, van den Bos, Mehdi, Geevasinga, Nimeshan, Vucic, Steve, Menon, Parvathi

“…•The split-hand index (SI) was assessed on both sides in a large cohort of ALS patient of varying clinical subtypes.•The SI was significantly reduced on both…”
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Physiological Biomarkers of Upper Motor Neuron Dysfunction in ALS by Calma, Aicee Dawn, van den Bos, Mehdi, Pavey, Nathan, Santos Silva, Cláudia, Menon, Parvathi, Vucic, Steve

“…Upper motor neuron (UMN) dysfunction is an important feature of amyotrophic lateral sclerosis (ALS) for the diagnosis and understanding of pathogenesis. The…”
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The split-elbow index: A biomarker of the split elbow sign in ALS by Pavey, Nathan, Higashihara, Mana, van den Bos, Mehdi A.J., Menon, Parvathi, Vucic, Steve

“…•Split elbow sign was significantly more common in amyotrophic lateral sclerosis (ALS).•The split elbow index is a novel neurophysiological measure in ALS.•The…”
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3106 Abnormalities of cortical stimulation strength-duration time constant in amyotrophic lateral sclerosis by Pavey, Nathan A, Menon, Parvathi, Peterchev, Angel V, Kiernan, Matthew C, Vucic, Steve

“…ObjectivesStrength-duration time constant (SDTC) may now be determined for cortical motor neurones, with activity mediated by transient Na+ conductances. The…”
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3107 Distinct neuronal circuits mediate cortical hyperexcitability in amyotrophic lateral sclerosis by Pavey, Nathan A, Hannaford, Andrew, Bos, Mehdi Van den, Kiernan, Matthew C, Menon, Parvathi, Vucic, Steve

“…BackgroundCortical hyperexcitability is an important pathophysiological mechanism in amyotrophic lateral sclerosis (ALS). The direction of transcranial…”
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Cortical inexcitability in ALS: correlating a clinical phenotype by Pavey, Nathan, Hannaford, Andrew, Higashihara, Mana, van den Bos, Mehdi, Geevasinga, Nimeshan, Vucic, Steve, Menon, Parvathi

“…BackgroundCortical inexcitability, a less studied feature of upper motor neuron (UMN) dysfunction in amyotrophic lateral sclerosis (ALS), was identified in a…”
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Neuroinflammation in amyotrophic lateral sclerosis: pathogenic insights and therapeutic implications by Calma, Aicee D, Pavey, Nathan, Menon, Parvathi, Vucic, Ostoja Steve

“…Neuroinflammation appears to be an important pathogenic process in amyotrophic lateral sclerosis (ALS). Dysfunction of central immune pathways, including…”
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Direct interrogation of cortical interneuron circuits in amyotrophic lateral sclerosis by van den Bos, Mehdi A J, Menon, Parvathi, Pavey, Nathan, Higashihara, Mana, Kiernan, Matthew C, Vucic, Steve

“…Cortical hyperexcitability is a key pathogenic feature of amyotrophic lateral sclerosis (ALS), believed to be mediated through complex interplay of cortical…”
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Distinct neuronal circuits mediate cortical hyperexcitability in amyotrophic lateral sclerosis by Pavey, Nathan, Hannaford, Andrew, van den Bos, Mehdi, Kiernan, Matthew C, Menon, Parvathi, Vucic, Steve

“…Cortical hyperexcitability is an important pathophysiological mechanism in amyotrophic lateral sclerosis (ALS), reflecting a complex interaction of inhibitory…”
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Association of Cortical Hyperexcitability and Cognitive Impairment in Patients With Amyotrophic Lateral Sclerosis by Higashihara, Mana, Pavey, Nathan, van den Bos, Mehdi, Menon, Parvathi, Kiernan, Matthew C., Vucic, Steve

“…To determine whether cortical hyperexcitability was more prominent in cognitively impaired patients with amyotrophic lateral sclerosis (ALS). Threshold…”
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Utility of split hand index with different motor unit number estimation techniques in ALS by Pavey, Nathan, Hannaford, Andrew, Higashihara, Mana, van den Bos, Mehdi, Kiernan, Matthew C., Menon, Parvathi, Vucic, Steve

“…•The split-hand index was significantly reduced in ALS using CMAP amplitude, motor unit number index and MScanFit-MUNE methods.•The split-hand index using the…”
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Clinical and neurophysiological biomarkers of disease progression in amyotrophic lateral sclerosis by Hannaford, Andrew, Byth, Karen, Pavey, Nathan, Henderson, Robert D., Mathers, Susan, Needham, Merrilee, Schultz, David, Menon, Parvathi, Kiernan, Matthew C., Vucic, Steve

“…Introduction/Aims Rate of disease progression (ΔFS), measured as change in the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS‐R) and…”
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Reduction in short interval intracortical inhibition from the early stage reflects the pathophysiology in amyotrophic lateral sclerosis: A meta‐analysis study by Higashihara, Mana, Pavey, Nathan, Menon, Parvathi, Bos, Mehdi, Shibuya, Kazumoto, Kuwabara, Satoshi, Kiernan, Matthew C., Koinuma, Masayoshi, Vucic, Steve

“…Background and purpose Cortical hyperexcitability has been identified as a diagnostic and pathogenic biomarker of amyotrophic lateral sclerosis (ALS). Cortical…”
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16. The Split Elbow Index: A novel diagnostic biomarker for motor neurone disease by Pavey, Nathan, Higashihara, Mana, Den Bos, Mehdi Van, Menon, Parvathi, Vucic, Steve

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Cortical inhibition and facilitation are mediated by distinct physiological processes by Pavey, Nathan, Menon, Parvathi, van den Bos, Mehdi A.J., Kiernan, Matthew C, Vucic, Steve

“…•Distinct cortical processes mediate intracortical inhibition in motor cortices.•Distinct cortical facilitatory processes mediate intracortical…”
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Novel approaches to assessing upper motor neuron dysfunction in motor neuron disease/amyotrophic lateral sclerosis: IFCN handbook chapter by Dharmadasa, Thanuja, Pavey, Nathan, Tu, Sicong, Menon, Parvathi, Huynh, William, Mahoney, Colin J., Timmins, Hannah C., Higashihara, Mana, van den Bos, Mehdi, Shibuya, Kazumoto, Kuwabara, Satoshi, Grosskreutz, Julian, Kiernan, Matthew C., Vucic, Steve

“…•Transcranial magnetic stimulation is an objective biomarker of upper motor neuron dysfunction in motor neuron disease (MND).•Cortical hyperexcitability is…”
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