Search Results - "Paveley, Ross"

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F by Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D G, Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn

“…Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally…”
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Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents by Giuliani, Sandra, Silva, Arthur C, Borba, Joyce V V B, Ramos, Pablo I P, Paveley, Ross A, Muratov, Eugene N, Andrade, Carolina Horta, Furnham, Nicholas

“…The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is…”
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Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases by Paveley, Ross A, Mansour, Nuha R, Hallyburton, Irene, Bleicher, Leo S, Benn, Alex E, Mikic, Ivana, Guidi, Alessandra, Gilbert, Ian H, Hopkins, Andrew L, Bickle, Quentin D

“…Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting…”
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CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection by Turner, Joseph D, Jenkins, Gavin R, Hogg, Karen G, Aynsley, Sarah A, Paveley, Ross A, Cook, Peter C, Coles, Mark C, Mountford, Adrian P

“…Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down-…”
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Application of RNAi to Genomic Drug Target Validation in Schistosomes by Guidi, Alessandra, Mansour, Nuha R, Paveley, Ross A, Carruthers, Ian M, Besnard, Jérémy, Hopkins, Andrew L, Gilbert, Ian H, Bickle, Quentin D

“…Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to…”
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QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni by Melo-Filho, Cleber C, Dantas, Rafael F, Braga, Rodolpho C, Neves, Bruno J, Senger, Mario R, Valente, Walter C. G, Rezende-Neto, João M, Chaves, Willian T, Muratov, Eugene N, Paveley, Ross A, Furnham, Nicholas, Kamentsky, Lee, Carpenter, Anne E, Silva-Junior, Floriano P, Andrade, Carolina H

“…Schistosomiasis is a neglected tropical disease that affects millions of people worldwide. Thioredoxin glutathione reductase of Schistosoma mansoni (SmTGR) is…”
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High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni by Mansour, Nuha R, Paveley, Ross, Gardner, J Mark F, Bell, Andrew S, Parkinson, Tanya, Bickle, Quentin

“…An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one…”
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Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells by Paveley, Ross A, Aynsley, Sarah A, Cook, Peter C, Turner, Joseph D, Mountford, Adrian P

“…Infection of the mammalian host by the parasitic helminth Schistosoma mansoni is accompanied by the release of excretory/secretory molecules (ES) from…”
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The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production by Paveley, Ross A., Aynsley, Sarah A., Turner, Joseph D., Bourke, Claire D., Jenkins, Stephen J., Cook, Peter C., Martinez-Pomares, Luisa, Mountford, Adrian P.

“…[Display omitted] ► Excretory/secretory (E/S) material from schistosome cercariae contains an abundance of glycans. ► Larval E/S has high binding specificity…”
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CD207+ Langerhans cells constitute a minor population of skin-derived antigen-presenting cells in the draining lymph node following exposure to Schistosoma mansoni by Kumkate, Supeecha, Jenkins, Gavin R., Paveley, Ross A., Hogg, Karen G., Mountford, Adrian P.

“…Infectious cercariae of Schistosoma mansoni gain entry to the mammalian host through the skin where they induce a transient inflammatory influx of mononuclear…”
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Selective targeting of PI3Kδ suppresses human IL-17-producing T cells and innate-like lymphocytes and may be therapeutic for IL-17-mediated diseases by Chen, Sijia, Paveley, Ross, Kraal, Lianne, Sritharan, Lathees, Stevens, Elizabeth, Dedi, Neesha, Shock, Anthony, Shaw, Stevan, Juarez, Maria, Yeremenko, Nataliya, Baeten, Dominique, Payne, Andrew

“…The delta isoform of phosphoinositide 3-kinase (PI3Kδ) regulates various lymphocyte functions. Considering the key pro-inflammatory role of IL-17A and IL-17F…”
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Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening by Neves, Bruno J, Dantas, Rafael F, Senger, Mario R, Melo-Filho, Cleber C, Valente, Walter C. G, de Almeida, Ana C. M, Rezende-Neto, João M, Lima, Elid F. C, Paveley, Ross, Furnham, Nicholas, Muratov, Eugene, Kamentsky, Lee, Carpenter, Anne E, Braga, Rodolpho C, Silva-Junior, Floriano P, Andrade, Carolina Horta

“…Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel…”
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Publisher Correction: Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ by Holdsworth, Gill, Bon, Hélène, Bergin, Marianne, Qureshi, Omar, Paveley, Ross, Atkinson, John, Huang, Linghong, Tewari, Roohi, Twomey, Breda, Johnson, Timothy

“…A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper…”
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Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ by Holdsworth, Gill, Bon, Hélène, Bergin, Marianne, Qureshi, Omar, Paveley, Ross, Atkinson, John, Huang, Linghong, Tewari, Roohi, Twomey, Breda, Johnson, Timothy

“…Fibrosis is a common driver of end-stage organ failure in most organs. It is characterised by excessive accumulation of extracellular matrix (ECM) proteins…”
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Abstract 3930: AI-driven discovery and profiling of GTAEXS-617, a selective and highly potent inhibitor of CDK7 by Besnard, Jérémy, Joseph, James, Bai, Haiyun, Paveley, Ross A., Wang, Tao, Barbeau, Olivier R., Gu, Xiao-Hui, Bell, Andrew S., Somlyay, Mate, Taubert, Christina, Boudesco, Christophe, Vladimer, Gregory, Aswad, Fred

“…Background: Uncontrolled cancer cell growth results from genetic lesions that disrupt mechanisms regulating cell cycle progression. Furthermore, these…”
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Application of RNAi to Genomic Drug Target Validation in Schistosomes: e0003801 by Guidi, Alessandra, Mansour, Nuha R, Paveley, Ross A, Carruthers, Ian M, Besnard, Jérémy, Hopkins, Andrew L, Gilbert, Ian H, Bickle, Quentin D

“…Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to…”
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The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNI super(3) production by Paveley, Ross A, Aynsley, Sarah A, Turner, Joseph D, Bourke, Claire D, Jenkins, Stephen J, Cook, Peter C, Martinez-Pomares, Luisa, Mountford, Adrian P

“…In this study, infective larvae of the parasitic helminth Schistosoma mansoni were shown to contain a large number of glycosylated components specific for the…”
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[CD25.sup.+] regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection by Turner, Joseph D, Jenkins, Gavin R, Hogg, Karen G, Aynsley, Sarah A, Paveley, Ross A, Cook, Peter C, Coles, Mark C, Mountford, Adrian P

“…Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down-…”
Get full text

Fluorescent Imaging of Antigen Released by a Skin-Invading Helminth Reveals Differential Uptake and Activation Profiles by Antigen Presenting Cells by Paveley, Ross A., Aynsley, Sarah A., Cook, Peter C., Turner, Joseph D., Mountford, Adrian P.

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