Search Results - "Pavel, Petra"

PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming by Blunder, Stefan, Pavel, Petra, Minzaghi, Deborah, Dubrac, Sandrine

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors expressed in the skin. Three PPAR isotypes, α (NRC1C1), β or δ (NRC1C2) and γ…”
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Atopic Dermatitis: The Fate of the Fat by Pavel, Petra, Blunder, Stefan, Moosbrugger-Martinz, Verena, Elias, Peter M, Dubrac, Sandrine

“…Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and itchy skin may develop into skin lesions. AD has a strong genetic…”
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Xenobiotic Receptors and Their Mates in Atopic Dermatitis by Minzaghi, Deborah, Pavel, Petra, Dubrac, Sandrine

“…Atopic dermatitis (AD) is the most common inflammatory skin disease worldwide. It is a chronic, relapsing and pruritic skin disorder which results from…”
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Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients by Stelmach, Patrick, Richter, Sarah, Sauer, Sandra, Fabre, Margarete A, Gu, Muxin, Rohde, Christian, Janssen, Maike, Liebers, Nora, Proynova, Rumyana, Weinhold, Niels, Raab, Marc S, Goldschmidt, Hartmut, Besenbeck, Birgit, Pavel, Petra, Laier, Sascha, Trumpp, Andreas, Dietrich, Sascha, Vassiliou, George S, Müller-Tidow, Carsten

“…Clonal hematopoiesis (CH) is an age-related condition driven by stem and progenitor cells harboring recurrent mutations linked to myeloid neoplasms. Currently,…”
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Current Challenges in Providing Good Leukapheresis Products for Manufacturing of CAR-T Cells for Patients with Relapsed/Refractory NHL or ALL by Korell, Felix, Laier, Sascha, Sauer, Sandra, Veelken, Kaya, Hennemann, Hannah, Schubert, Maria-Luisa, Sauer, Tim, Pavel, Petra, Mueller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael, Schmitt, Anita

“…T lymphocyte collection through leukapheresis is an essential step for chimeric antigen receptor T (CAR-T) cell therapy. Timing of apheresis is challenging in…”
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Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial by Schubert, Maria-Luisa, Schmitt, Anita, Hückelhoven-Krauss, Angela, Neuber, Brigitte, Kunz, Alexander, Waldhoff, Philip, Vonficht, Dominik, Yousefian, Schayan, Jopp-Saile, Lea, Wang, Lei, Korell, Felix, Keib, Anna, Michels, Birgit, Haas, Dominik, Sauer, Tim, Derigs, Patrick, Kulozik, Andreas, Kunz, Joachim, Pavel, Petra, Laier, Sascha, Wuchter, Patrick, Schmier, Johann, Bug, Gesine, Lang, Fabian, Gökbuget, Nicola, Casper, Jochen, Görner, Martin, Finke, Jürgen, Neubauer, Andreas, Ringhoffer, Mark, Wolleschak, Denise, Brüggemann, Monika, Haas, Simon, Ho, Anthony D, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael

“…Third-generation chimeric antigen receptor (CAR)-engineered T cells (CARTs) might improve clinical outcome of patients with B cell malignancies. This is the…”
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Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution by Sauer, Sandra, Pavel, Petra, Schmitt, Anita, Cremer, Martin, Kriegsmann, Mark, Bruckner, Thomas, Jordan, Karin, Wuchter, Patrick, Müller-Tidow, Carsten, Kriegsmann, Katharina

“…High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients…”
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3D-Organotypic Cultures to Unravel Molecular and Cellular Abnormalities in Atopic Dermatitis and Ichthyosis Vulgaris by Leman, Géraldine, Moosbrugger-Martinz, Verena, Blunder, Stefan, Pavel, Petra, Dubrac, Sandrine

“…Atopic dermatitis (AD) is characterized by dry and itchy skin evolving into disseminated skin lesions. AD is believed to result from a primary acquired or a…”
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Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis by Pavel, Petra, Leman, Géraldine, Hermann, Martin, Ploner, Christian, Eichmann, Thomas O., Minzaghi, Deborah, Radner, Franz P.W., Del Frari, Barbara, Gruber, Robert, Dubrac, Sandrine

“…Alterations of the lipid profile of the stratum corneum have an important role in the pathogenesis of atopic dermatitis (AD) because they contribute to…”
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A Freezing Protocol for Hematopoietic Stem Cells by Pavel, Petra, Laier, Sascha

“…Especially in the field of autologous transplantation, it has been found necessary to develop methods that ensure long-term storage with maintenance of…”
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Excessive Production of Hydrogen Peroxide in Mitochondria Contributes to Atopic Dermatitis by Minzaghi, Deborah, Pavel, Petra, Kremslehner, Christopher, Gruber, Florian, Oberreiter, Sophie, Hagenbuchner, Judith, Del Frari, Barbara, Blunder, Stefan, Gruber, Robert, Dubrac, Sandrine

“…Atopic dermatitis (AD) is a complex disease characterized by chronic recurring eczema and pruritus. In addition, patients with AD display increased cutaneous…”
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The First Real-World Experience with Betibeglogene Autotemcel (beti-cel) Gene Therapy Treatment for Transfusion-Dependent β-Thalassemia (TDT) by Kunz, Joachim B., Roth, Eva, Mirza, Adil, Greil, Johann, Pavel, Petra, Schmitt, Anita, Schmitt, Michael, Kunz, Alexander, Kulozik, Andreas E.

“…Background Beti-cel ex vivo gene therapy integrates a modified HBB gene into hematopoietic stem cells of patients with TDT, aiming to enable lifelong, stable…”
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Mitochondrial Activity Is Upregulated in Nonlesional Atopic Dermatitis and Amenable to Therapeutic Intervention by Leman, Geraldine, Pavel, Petra, Hermann, Martin, Crumrine, Debra, Elias, Peter M., Minzaghi, Deborah, Goudounèche, Dominique, Roshardt Prieto, Natalia M., Cavinato, Maria, Wanner, Andrea, Blunder, Stefan, Gruber, Robert, Jansen-Dürr, Pidder, Dubrac, Sandrine

“…Previous work has shown increased expression of genes related to oxidative stress in nonlesional atopic dermatitis (ADNL) skin. Although mitochondria are key…”
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Standardization of Good Manufacturing Practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications by Wuchter, Patrick, Bieback, Karen, Schrezenmeier, Hubert, Bornhäuser, Martin, Müller, Lutz P, Bönig, Halvard, Wagner, Wolfgang, Meisel, Roland, Pavel, Petra, Tonn, Torsten, Lang, Peter, Müller, Ingo, Renner, Matthias, Malcherek, Georg, Saffrich, Rainer, Buss, Eike C, Horn, Patrick, Rojewski, Markus, Schmitt, Anita, Ho, Anthony D, Sanzenbacher, Ralf, Schmitt, Michael

“…Abstract Background aims Human mesenchymal stem or stromal cells (MSCs) represent a potential resource not only for regenerative medicine but also for…”
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Third-Generation Chimeric Antigen Receptor (CAR) T Cells in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin Lymphoma (NHL) - Results from the Heidelberg Trial 1 (HD-CAR-1 trial) by Schubert, Maria-Luisa, Schmitt, Anita, Neuber, Brigitte, Hückelhoven-Krauss, Angela, Kunz, Alexander, Wang, Lei, Michels, Birgit, Waldhoff, Philip, Sellner, Leopold, Korell, Felix, Hofmann, Susanne, Pavel, Petra, Ho, Anthony D, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael

“…Introduction Chimeric antigen receptor (CAR) T cell (CART) therapy has shown to be a new and very promising therapeutical method in patients with relapsed or…”
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Low-dose cyclophosphamide effectively mobilizes peripheral blood stem cells in patients with autoimmune disease by Blank, Norbert, Lisenko, Katharina, Pavel, Petra, Bruckner, Thomas, Ho, Anthony D., Wuchter, Patrick

“…For patients with severe and refractory autoimmune diseases, high‐dose chemotherapy and autologous hematopoietic stem cell transplantation has been established…”
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Comparison between intermittent and continuous spectra optia leukapheresis systems for autologous peripheral blood stem cell collection by Lisenko, Katharina, Pavel, Petra, Bruckner, Thomas, Puthenparambil, Joe, Hundemer, Michael, Schmitt, Anita, Witzens‐Harig, Mathias, Ho, Anthony D., Wuchter, Patrick

“…Terumo BCT recently introduced a new system for mononuclear cell (MNC) collection that uses a Spectra Optia apheresis machine equipped with a redesigned…”
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Gene Therapy in Transfusion-Dependent Non-β0/β0 Genotype β-Thalassemia: First Real-World Experience of Beti-cel by Mirza, Adil, Ritsert, Mona-Lisa, Tao, Gloria, Thakar, Himal, Lobitz, Stephan, Heine, Sabine, Koscher, Leila, Dürken, Matthias, Schmitt, Anita, Schmitt, Michael, Pavel, Petra, Laier, Sascha, Jakoby, Donate, Greil, Johann, Kunz, Joachim B, Kulozik, Andreas

“…Gene addition and editing strategies for transfusion-dependent β-thalassemia have gained momentum as potentially curative treatment options, with studies…”
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Comparison of biosimilar filgrastim, originator filgrastim, and lenograstim for autologous stem cell mobilization in patients with multiple myeloma by Lisenko, Katharina, Baertsch, Marc‐Andrea, Meiser, Renate, Pavel, Petra, Bruckner, Thomas, Kriegsmann, Mark, Schmitt, Anita, Witzens‐Harig, Mathias, Ho, Anthony D., Hillengass, Jens, Wuchter, Patrick

“…BACKGROUND Granulocyte–colony‐stimulating factor (G‐CSF) originators such as filgrastim (Neupogen) and lenograstim (Granocyte) are widely used for peripheral…”
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Cryostorage to What End? – Autologous Stem Cell Products in Burkitt Lymphoma, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and Myeloproliferative Neoplasm Patients by Kriegsmann, Katharina, Pavel, Petra, Bochtler, Tilmann, Schmitt, Anita, Sauer, Sandra, Kriegsmann, Mark, Bruckner, Thomas, Klein, Stefan, Klüter, Harald, Müller-Tidow, Carsten, Wuchter, Patrick

“…Introduction: Recently, we identified a huge discrepancy between the collection practice and the actual utilization of cryopreserved peripheral blood stem…”
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