Search Results - "Pavan, Aline Renata"

Epigenetic Regulatory Mechanisms Induced by Resveratrol by Fernandes, Guilherme Felipe Santos, Silva, Gabriel Dalio Bernardes, Pavan, Aline Renata, Chiba, Diego Eidy, Chin, Chung Man, Dos Santos, Jean Leandro

“…Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including…”
Get full text

Unraveling the Anticancer Effect of Curcumin and Resveratrol by Pavan, Aline Renata, Silva, Gabriel Dalio Bernardes da, Jornada, Daniela Hartmann, Chiba, Diego Eidy, Fernandes, Guilherme Felipe Dos Santos, Man Chin, Chung, Dos Santos, Jean Leandro

“…Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last…”
Get full text

Vascular Effects of the Fetal Hemoglobin Inducer Agent 3-(1,3-Dioxoisoindolin-2-yl) Benzyl Nitrate by Terroni, Barbara, de Moraes, Luis Henrique Oliveira, Pavan, Aline Renata, Rodrigues, Gerson Jhonatan, Dos Santos, Jean Leandro

“…Vascular endothelium is a protective layer of cells lining the lumen of blood vessels that plays important roles by releasing factors responsible for…”
Get full text

Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus by Lourenço de Freitas, Natália, Deberaldini, Maria Gabriela, Gomes, Diana, Pavan, Aline Renata, Sousa, Ângela, Dos Santos, Jean Leandro, Soares, Christiane P

“…The role of epigenetic modifications on the carcinogenesis process has received a lot of attention in the last years. Among those, histone acetylation is a…”
Get full text

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery by Bonjorno, Andressa Francielli, Pavan, Aline Renata, Fernandes, Guilherme F S, Scarim, Cauê Benito, Castagnolo, Daniele, Dos Santos, Jean Leandro

“…Tuberculosis (TB) has claimed more lives over the course of two millennia than any other infectious disease worldwide. In 2021, the World Health Organization…”
Get full text

Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors by Urias, Beatriz Silva, Pavan, Aline Renata, Albuquerque, Gabriela Ribeiro, Prokopczyk, Igor Muccilo, Alves, Tânia Mara Ferreira, de Melo, Thais Regina Ferreira, Sartori, Geraldo Rodrigues, da Silva, João Hermínio Martins, Chin, Chung Man, Santos, Jean Leandro Dos

“…Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore,…”
Get full text

Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease by Pavan, Aline Renata, Lopes, Juliana Romano, Lima Imperador, Carlos Henrique, Man Chin, Chung, dos Santos, Jean Leandro

Get full text

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events by Rosseto, Leandro Augusto, Pires, Maria Elisa Lopes, Melchior, Aylime Castanho Bolognesi, Bosquesi, Priscila Longhin, Pavan, Aline Renata, Marcondes, Sisi, Chung, Man Chin, Santos, Jean Leandro Dos

“…Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet…”
Get full text

The state of the art of fetal hemoglobin-inducing agents by Pavan, Aline Renata, Lopes, Juliana Romano, Dos Santos, Jean Leandro

“…Sickle cell anemia (SCA) is a hematological genetic disorder caused by a mutation in the gene of the β-globin. Pharmacological treatments will continue to be…”
Get more information

Endothelial dysfunction in Sickle Cell Disease: Strategies for the treatment by Pavan, Aline Renata, Terroni, Barbara, Dos Santos, Jean Leandro

“…Sickle Cell Anemia (SCA), is an inherited hemoglobinopathy characterized by the presence of an abnormal hemoglobin (HbS), being the most prevalent sickle cell…”
Get full text

In silico drug design strategies for discovering novel tuberculosis therapeutics by Canales, Christian S Carnero, Pavan, Aline Renata, Dos Santos, Jean Leandro, Pavan, Fernando Rogério

“…Tuberculosis remains a significant concern in global public health due to its intricate biology and propensity for developing antibiotic resistance…”
Get more information

BacPROTAC approach for tuberculosis drug discovery by Bonjorno, Andressa Francielli, Pavan, Aline Renata, Lopes, Juliana Romano, Prates, João Lucas Bruno, de Souza, Mateus Mello, Scarim, Cauê Benito, dos Santos, Jean Leandro

“…According to the World Health Organization, tuberculosis (TB) continued to be a significant health burden in 2023, affecting an estimated 10 million…”
Get full text

Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers by Bosquesi, Priscila Longhin, Melchior, Aylime Castanho Bolognesi, Pavan, Aline Renata, Lanaro, Carolina, de Souza, Cristiane Maria, Rusinova, Radda, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, Fernandes, Guilherme Felipe dos Santos, Carlos, Iracilda Zepone, Andersen, Olaf Sparre, Costa, Fernando Ferreira, Dos Santos, Jean Leandro

“…[Display omitted] •New resveratrol derivatives (10a-i) with NO-donor properties.•All compounds exhibited in vivo analgesic effect.•All compounds did not induce…”
Get full text