Search Results - "Pauwels, Jarne"

Distinct branches of the N-end rule pathway modulate the plant immune response by Vicente, Jorge, Mendiondo, Guillermina M., Pauwels, Jarne, Pastor, Victoria, Izquierdo, Yovanny, Naumann, Christin, Movahedi, Mahsa, Rooney, Daniel, Gibbs, Daniel J., Smart, Katherine, Bachmair, Andreas, Gray, Julie E., Dissmeyer, Nico, Castresana, Carmen, Ray, Rumiana V., Gevaert, Kris, Holdsworth, Michael J.

“…• The N-end rule pathway is a highly conserved constituent of the ubiquitin proteasome system, yet little is known about its biological roles. • Here we…”
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A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency by Tharkeshwar, Arun Kumar, Trekker, Jesse, Vermeire, Wendy, Pauwels, Jarne, Sannerud, Ragna, Priestman, David A., te Vruchte, Danielle, Vints, Katlijn, Baatsen, Pieter, Decuypere, Jean-Paul, Lu, Huiqi, Martin, Shaun, Vangheluwe, Peter, Swinnen, Johannes V., Lagae, Liesbet, Impens, Francis, Platt, Frances M., Gevaert, Kris, Annaert, Wim

“…Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in…”
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Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience by Willems, Patrick, Van Ruyskensvelde, Valerie, Maruta, Takanori, Pottie, Robin, Fernández-Fernández, Álvaro D., Pauwels, Jarne, Hannah, Matthew A., Gevaert, Kris, Van Breusegem, Frank, Van der Kelen, Katrien

“…Alternative splicing is a key posttranscriptional gene regulatory process, acting in diverse adaptive and basal plant processes. Splicing of…”
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Simple Peptide Quantification Approach for MS-Based Proteomics Quality Control by Maia, Teresa Mendes, Staes, An, Plasman, Kim, Pauwels, Jarne, Boucher, Katie, Argentini, Andrea, Martens, Lennart, Montoye, Tony, Gevaert, Kris, Impens, Francis

“…Despite its growing popularity and use, bottom-up proteomics remains a complex analytical methodology. Its general workflow consists of three main steps:…”
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A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment by De Vlieghere, Elly, Van de Vijver, Koen, Blondeel, Eva, Carpentier, Nathan, Ghobeira, Rouba, Pauwels, Jarne, Riemann, Sebastian, Minsart, Manon, Fieuws, Charlotte, Mestach, Johanna, Baeyens, Ans, De Geyter, Nathalie, Debbaut, Charlotte, Denys, Hannelore, Descamps, Benedicte, Claes, Kathleen, Vral, Anne, Van Dorpe, Jo, Gevaert, Kris, De Geest, Bruno G, Ceelen, Wim, Van Vlierberghe, Sandra, De Wever, Olivier

“…Abstract Background Long-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include…”
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Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation by Naus, Evelyne, Derweduwe, Marleen, Lampi, Youlia, Claeys, Annelies, Pauwels, Jarne, Langenberg, Tobias, Claes, Filip, Xu, Jie, Haemels, Veerle, Atak, Zeynep Kalender, van der Kant, Rob, Van Durme, Joost, De Baets, Greet, Ligon, Keith L, Fiers, Mark, Gevaert, Kris, Aerts, Stein, Rousseau, Frederic, Schymkowitz, Joost, De Smet, Frederik

“…In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that…”
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Mass spectrometry-based clinical proteomics - a revival by Pauwels, Jarne, Gevaert, Kris

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Mass spectrometry and the cellular surfaceome by Pauwels, Jarne, Fijałkowska, Daria, Eyckerman, Sven, Gevaert, Kris

“…The collection of exposed plasma membrane proteins, collectively termed the surfaceome, is involved in multiple vital cellular processes, such as the…”
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A Well-Controlled BioID Design for Endogenous Bait Proteins by Vandemoortele, Giel, De Sutter, Delphine, Moliere, Aline, Pauwels, Jarne, Gevaert, Kris, Eyckerman, Sven

“…The CRISPR/Cas9 revolution is profoundly changing the way life sciences technologies are used. Many assays now rely on engineered clonal cell lines to…”
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Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling by Lu, Qing, Zhang, Yonghong, Hellner, Joakim, Giannini, Caterina, Xu, Xiangyu, Pauwels, Jarne, Ma, Qian, Dejonghe, Wim, Han, Huibin, Van de Cotte, Brigitte, Impens, Francis, Gevaert, Kris, De Smet, Ive, Friml, Jiří, Molina, Daniel Martinez, Russinova, Eugenia

“…SignificanceChemical genetics, which investigates biological processes using small molecules, is gaining interest in plant research. However, a major challenge…”
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DYn-2 Based Identification of Arabidopsis Sulfenomes[S] by Akter, Salma, Huang, Jingjing, Bodra, Nandita, De Smet, Barbara, Wahni, Khadija, Rombaut, Debbie, Pauwels, Jarne, Gevaert, Kris, Carroll, Kate, Van Breusegem, Frank, Messens, Joris

“…Identifying the sulfenylation state of stressed cells is emerging as a strategic approach for the detection of key reactive oxygen species signaling proteins…”
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High-Throughput Nanoflow Proteomics Using a Dual-Column Electrospray Source by Staes, An, Boucher, Katie, Dufour, Sara, Maia, Teresa Mendes, Timmerman, Evy, Haver, Delphi Van, Pauwels, Jarne, Demol, Hans, Vandenbussche, Jonathan, Gevaert, Kris, Impens, Francis, Devos, Simon

“…With current trends in proteomics, especially regarding clinical and low input (to single cell) samples, it is increasingly important to both maximize the…”
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Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress by Nguyen, Phuong N., Tossounian, Maria-Armineh, Kovacs, Denes S., Thu, Tran T., Stijlemans, Benoit, Vertommen, Didier, Pauwels, Jarne, Gevaert, Kris, Angenon, Geert, Messens, Joris, Tompa, Peter

“…Fully intrinsically disordered plant dehydrin ERD14 can protect enzymes via its chaperone-like activity, but it was not formally linked with enzymes of the…”
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N-glycosylation Site Analysis Reveals Sex-related Differences in Protein N-glycosylation in the Rice Brown Planthopper (Nilaparvata lugens) by Scheys, Freja, Van Damme, Els J.M., Pauwels, Jarne, Staes, An, Gevaert, Kris, Smagghe, Guy

“…N-glycosylation sites were analyzed for proteins from the adult morphs of the rice brown planthopper (Nilaparvata lugens). The results showed that protein…”
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The lectin Orysata induces phosphatase-mediated and carbohydrate-independent aggregation of insect cells by Chen, Pengyu, De Schutter, Kristof, Pauwels, Jarne, Gevaert, Kris, Van Damme, Els J.M., Smagghe, Guy

“…[Display omitted] •Treatment with Orysata lectin causes aggregation in insect cells.•Cell aggregation is independent from carbohydrate-binding activity of the…”
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Binding of Orysata lectin induces an immune response in insect cells by Chen, Pengyu, De Schutter, Kristof, Pauwels, Jarne, Gevaert, Kris, Van Damme, Els J. M., Smagghe, Guy

“…In mammals, plant lectinshave been shown to possess immunomodulatory properties, acting in both the innate and adaptive immune system to modulate the…”
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N-glycosylation Site Analysis Reveals Sex-related Differences in Protein N-glycosylation in the Rice Brown Planthopper (Nilaparvata lugens) by Scheys, Freja, Van Damme, Els J M, Pauwels, Jarne, Staes, An, Gevaert, Kris, Smagghe, Guy

“…Glycosylation is a common modification of proteins and critical for a wide range of biological processes. Differences in protein glycosylation between sexes…”
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Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression by Pinto, Ana Teresa, Machado, Ana Beatriz, Osório, Hugo, Pinto, Marta Laranjeiro, Vitorino, Rui, Justino, Gonçalo, Santa, Cátia, Castro, Flávia, Cruz, Tânia, Rodrigues, Carla, Lima, Jorge, Sousa, José Luís R, Cardoso, Ana Patrícia, Figueira, Rita, Monteiro, Armanda, Marques, Margarida, Manadas, Bruno, Pauwels, Jarne, Gevaert, Kris, Mareel, Marc, Rocha, Sónia, Duarte, Tiago, Oliveira, Maria José

“…To identify a molecular signature of macrophages exposed to clinically relevant ionizing radiation (IR) doses, mirroring radiotherapy sessions. Human…”
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Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools by Bekesi, Angela, Abdellaoui, Sara, Holroyd, Natalie, Van Delm, Wouter, Pardon, Els, Pauwels, Jarne, Gevaert, Kris, Steyaert, Jan, Derveaux, Stefaan, Borysik, Antoni, Tompa, Peter

“…The structural and functional characterization of large multidomain signaling proteins containing long disordered linker regions represents special…”
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