Search Results - "Pauthner, Matthias G."
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Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers
Published in Immunity (Cambridge, Mass.) (15-01-2019)“…Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus…”
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Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades
Published in Nature communications (27-09-2022)“…Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly spills over to humans from its rodent reservoirs. It is currently…”
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Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome
Published in Journal of virology (23-11-2020)“…Given the complex biology of human immunodeficiency virus (HIV) and its remarkable capacity to evade host immune responses, HIV vaccine efficacy may benefit…”
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Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers
Published in Frontiers in immunology (16-06-2020)“…T follicular helper (T ) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to…”
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Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies
Published in Molecular therapy. Methods & clinical development (13-03-2020)“…Structural characterization of the HIV-1 Envelope (Env) glycoprotein has facilitated the development of Env probes to isolate HIV-specific monoclonal…”
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Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
Published in Cell (16-05-2019)“…Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other…”
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Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
Published in The New England journal of medicine (01-04-2021)“…In this report from the Democratic Republic of Congo, Ebola virus disease (EVD) developed in a young man, and he recovered after treatment with a monoclonal…”
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A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge
Published in Cell host & microbe (11-09-2019)“…Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates…”
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A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus
Published in Immunity (Cambridge, Mass.) (13-04-2021)“…Protective Ebola virus (EBOV) antibodies have neutralizing activity and induction of antibody constant domain (Fc)-mediated innate immune effector functions…”
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Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo
Published in Nature Medicine (01-04-2021)“…On 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the…”
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Lassa Virus Genetics
Published in Current topics in microbiology and immunology (2023)“…In a pattern repeated across a range of ecological niches, arenaviruses have evolved a compact four-gene genome to orchestrate a complex life cycle in a narrow…”
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Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
Published in CELL (09-01-2020)Get full text
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Mamu-B17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication
Published in Journal of virology (15-08-2018)“…Certain major histocompatibility complex class I (MHC-I) alleles are associated with spontaneous control of viral replication in human immunodeficiency virus…”
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Ebola Virus Transmission Initiated by Systemic Ebola Virus Disease Relapse
Published in The New England journal of medicine (01-04-2021)“…During the 2018-2020 Nord Kivu Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo, an individual who had received the Merck rVSV-ZEBOV…”
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A meta-analysis of passive immunization studies shows an association of serum neutralizing antibody titer with protection against SHIV challenge
Published in Cell host & microbe (11-09-2019)“…Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV envelope glycoprotein (Env) have been shown to protect nonhuman primates…”
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