Search Results - "Paus, Ralf"

Alopecia Areata by Gilhar, Amos, Etzioni, Amos, Paus, Ralf

“…This review article synthesizes relevant information about hair-follicle biology and pathobiology and summarizes the clinical presentation and management of…”
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A neuroendocrinological perspective on human hair follicle pigmentation by Paus, Ralf

“…Summary The role of neurohormones and neuropeptides in human hair follicle (HF) pigmentation extends far beyond the control of melanin synthesis by α‐MSH and…”
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Hair follicle immune privilege and its collapse in alopecia areata by Bertolini, Marta, McElwee, Kevin, Gilhar, Amos, Bulfone‐Paus, Silvia, Paus, Ralf

“…Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms…”
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Frontiers in alopecia areata pathobiology research by Gilhar, Amos, Laufer-Britva, Rimma, Keren, Aviad, Paus, Ralf

“…This current review explores selected and as yet insufficiently investigated frontiers in current alopecia areata (AA) pathobiology research, with an emphasis…”
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Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance by Paus, Ralf

“…The “thyroid–skin connection” has become a hot frontier in dermatoendocrinology. In this context, the pituitary hormone that controls thyroid hormone…”
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How UV Light Touches the Brain and Endocrine System Through Skin, and Why by Slominski, Andrzej T, Zmijewski, Michal A, Plonka, Przemyslaw M, Szaflarski, Jerzy P, Paus, Ralf

“…Abstract The skin, a self-regulating protective barrier organ, is empowered with sensory and computing capabilities to counteract the environmental stressors…”
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Macrophages contribute to the cyclic activation of adult hair follicle stem cells by Castellana, Donatello, Paus, Ralf, Perez-Moreno, Mirna

“…Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how…”
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions by Slominski, Andrzej T., Hardeland, Ruediger, Zmijewski, Michal A., Slominski, Radomir M., Reiter, Russel J., Paus, Ralf

“…Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland…”
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Pathobiology of chemotherapy-induced hair loss by Paus, Ralf, Prof, Haslam, Iain S, PhD, Sharov, Andrey A, MD, Botchkarev, Vladimir A, Prof

“…Summary Hair loss can be a psychologically devastating adverse effect of chemotherapy, but satisfactory management strategies for chemotherapy-induced alopecia…”
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Seborrheic dermatitis—Looking beyond Malassezia by Wikramanayake, Tongyu C., Borda, Luis J., Miteva, Mariya, Paus, Ralf

“…Seborrhoeic Dermatitis (SD) is a very common chronic and/or relapsing inflammatory skin disorder whose pathophysiology remains poorly understood. Yeast of the…”
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Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel Therapeutics by Hawkshaw, Nathan J., Paus, Ralf

“…The immunophilin ligand, cyclosporine A (CsA), which inhibits nuclear factor of activated T cells (NFAT) activity, is a cornerstone of immunosuppressive…”
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Olfactory receptor OR2AT4 regulates human hair growth by Chéret, Jérémy, Bertolini, Marta, Ponce, Leslie, Lehmann, Janin, Tsai, Teresa, Alam, Majid, Hatt, Hanns, Paus, Ralf

“…Olfactory receptors are expressed by different cell types throughout the body and regulate physiological cell functions beyond olfaction. In particular, the…”
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The Pathogenesis of Primary Cicatricial Alopecias by Harries, Matthew J, Paus, Ralf

“…Cicatricial (scarring) alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the hair follicle, generally as a…”
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Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase by Figlak, Katarzyna, Williams, Greg, Bertolini, Marta, Paus, Ralf, Philpott, Michael P.

“…Hair follicles (HFs) are unique, multi-compartment, mini-organs that cycle through phases of active hair growth and pigmentation (anagen), apoptosis-driven…”
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Vellus-to-terminal Hair Follicle Reconversion Occurs in Male Pattern Balding and is Promoted by Minoxidil and Platelet-rich Plasma: In Vivo Evidence from a New Humanized Mouse Model of Androgenetic Alopecia by Gilhar, Amos, Keren, Aviad, Paus, Ralf

“…Abstract is missing (Short communication)…”
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Mouse models of atopic dermatitis: a critical reappraisal by Gilhar, Amos, Reich, Kristian, Keren, Aviad, Kabashima, Kenji, Steinhoff, Martin, Paus, Ralf

“…Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for testing new candidate AD therapeutics and for interrogating AD…”
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Growth Hormone and the Human Hair Follicle by Horesh, Elijah J, Chéret, Jérémy, Paus, Ralf

“…Ever since the discoveries that human hair follicles (HFs) display the functional peripheral equivalent of the hypothalamic-pituitary-adrenal axis, exhibit…”
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Sebocytes, multifaceted epithelial cells: Lipid production and holocrine secretion by Schneider, Marlon R., Paus, Ralf

“…Sebocytes are highly specialized, sebum-producing epithelial cells that release their content by rupture of the cell membrane and cellular degradation…”
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Human hair follicle organ culture: theory, application and perspectives by Langan, Ewan A., Philpott, Michael P., Kloepper, Jennifer E., Paus, Ralf

“…For almost a quarter of a century, ex vivo studies of human scalp hair follicles (HFs) have permitted major advances in hair research, spanning diverse fields…”
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Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo by Nicu, Carina, Jackson, Jennifer, Shahmalak, Asim, Pople, Jenny, Ansell, David, Paus, Ralf

“…Adiponectin reportedly stimulates proliferation and elongation of human scalp hair follicles (HFs) ex vivo. In the current study, we investigated how…”
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