Search Results - "Paus, Didrik"
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Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses
Published in Immunity (Cambridge, Mass.) (21-08-2009)“…Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct…”
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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
Published in The Journal of experimental medicine (17-04-2006)“…B cells responding to T-dependent antigen either differentiate rapidly into extrafollicular plasma cells or enter germinal centers and undergo somatic…”
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Mapping Epitopes and Antigenicity by Site-Directed Masking
Published in Proceedings of the National Academy of Sciences - PNAS (13-06-2006)“…Here we describe a method for mapping the binding of antibodies to the surface of a folded antigen. We first created a panel of mutant antigens (β-lactamase)…”
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High affinity germinal center B cells are actively selected into the plasma cell compartment
Published in The Journal of experimental medicine (30-10-2006)“…A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum antibodies to bind antigen and provide immune protection…”
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Visualizing the effects of antigen affinity on T-dependent B-cell differentiation
Published in Immunology and cell biology (01-01-2008)“…Burnet's original description of the clonal selection hypothesis of antibody production included many prescient predictions of how ‘lymphocytes carrying…”
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Inhomogeneous alginate gel spheres: An assessment of the polymer gradients by synchrotron radiation‐induced x‐ray emission, magnetic resonance microimaging, and mathematical modeling
Published in BIOPOLYM (01-01-2000)“…It has been previously demonstrated that calcium alginate gels prepared by dialysis often exhibit a concentration inhomogeneity being the polymer concentration…”
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Mapping the Topographic Epitopes of a Model Antigen
Published 01-01-2003“…The thesis describes the development of a method for determining the antigenicity of different regions of the surface of a protein. The method involved the…”
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Dissertation