Search Results - "Pauly, Melinda"

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment by Dong, Lei, Yu, Wen-Mei, Zheng, Hong, Loh, Mignon L., Bunting, Silvia T., Pauly, Melinda, Huang, Gang, Zhou, Muxiang, Broxmeyer, Hal E., Scadden, David T., Qu, Cheng-Kui

“…Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic…”
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Severe COVID‐19 disease in two pediatric oncology patients by Stokes, Claire L., Patel, Pratik A., Sabnis, Himalee S., Mitchell, Sarah G., Yildirim, Inci B., Pauly, Melinda G.

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Immune responses and therapeutic challenges in paediatric patients with new‐onset acute myeloid leukaemia and concomitant COVID‐19 by Patel, Pratik A., Lapp, Stacey A., Grubbs, Gabrielle, Edara, Venkata V., Rostad, Christina A., Stokes, Claire L., Pauly, Melinda G., Anderson, Evan J., Piantadosi, Anne, Suthar, Mehul S., Khurana, Surender, Sabnis, Himalee S.

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Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia by Mumme, Hope, Thomas, Beena E., Bhasin, Swati S., Krishnan, Upaasana, Dwivedi, Bhakti, Perumalla, Pruthvi, Sarkar, Debasree, Ulukaya, Gulay B., Sabnis, Himalee S., Park, Sunita I., DeRyckere, Deborah, Raikar, Sunil S., Pauly, Melinda, Summers, Ryan J., Castellino, Sharon M., Wechsler, Daniel S., Porter, Christopher C., Graham, Douglas K., Bhasin, Manoj

“…Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing…”
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BCMA CAR-T induces complete and durable remission in refractory plasmablastic lymphoma by Raghunandan, Sharmila, Pauly, Melinda, Blum, William G, Qayed, Muna, Dhodapkar, Madhav V, Elkhalifa, Mohamed, Watkins, Benjamin, Schoettler, Michelle, Horwitz, Edwin, Parikh, Suhag, Chandrakasan, Shanmuganathan, Leung, Kathryn, Bryson, Elyse, Deeb, Laura, Kaufman, Jonathan L, Worthington-White, Diana, Alazraki, Adina, Schecter, Jordan M, Madduri, Deepu, Jackson, Carolyn C, Zudaire, Enrique, Taraseviciute-Morris, Agne, Babich, Alexander, Nesheiwat, Tonia, Vogel, Martin, Lendvai, Nikoletta, Pacaud, Lida, Williams, Kirsten M

“…Plasmablastic lymphoma (PBL) is a rare subtype of aggressive large B-cell lymphoma, with a dismal prognosis despite aggressive therapies. New approaches are…”
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Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children's Oncology Group trial AALL15P1 by Guest, Erin M, Kairalla, John A, Devidas, Meenakshi, Hibbitts, Emily, Carroll, Andrew J, Heerema, Nyla A, Kubaney, Holly R, August, Margaret A, Ramesh, Sidharth, Yoo, Byunggil, Farooqi, Midhat S, Pauly, Melinda G, Wechsler, Daniel S, Miles, Rodney R, Reid, Joel M, Kihei, Cynthia D, Gore, Lia, Raetz, Elizabeth A, Hunger, Stephen P, Loh, Mignon L, Brown, Patrick A

“…Infants less than 1 year old diagnosed with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) are at high risk of remission failure, relapse, and…”
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Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care by Summers, Ryan J, Castellino, Sharon M, Porter, Christopher C, MacDonald, Tobey J, Basu, Gargi D, Szelinger, Szabolcs, Bhasin, Manoj K, Cash, Thomas, Carter, Alexis B, Castellino, Robert Craig, Fangusaro, Jason R, Mitchell, Sarah G, Pauly, Melinda G, Pencheva, Bojana, Wechsler, Daniel S, Graham, Douglas K, Goldsmith, Kelly C

“…Profiling of pediatric cancers through deep sequencing of large gene panels and whole exomes is rapidly being adopted in many clinical settings. However, the…”
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Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis by Miller, Lane H., Qu, Cheng-Kui, Pauly, Melinda

“…•Normal hematopoiesis is regulated by a complex set of interactions between hematopoietic stem cells (HSCs) and their niches.•Mutations in stromal cells can…”
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Evaluating approaches to enhance survival in children with hypodiploid acute lymphoblastic leukaemia (ALL) by Miller, Lane, Kobayashi, Shogo, Pauly, Melinda, Lew, Glen, Saxe, Debra, Keller, Frank, Qayed, Muna, Castellino, Sharon

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Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) by Burke, Michael J., Ziegler, David S., Bautista, Francisco, Attarbaschi, Andishe, Gore, Lia, Locatelli, Franco, O'Brien, Maureen M., Pauly, Melinda, Obreja, Mihaela, Morris, Christopher L., Baruchel, Andre

“…Salvage options for children with relapsed ALL remain sub-optimal, particularly for T-cell ALL, with disease refractoriness and further relapse remaining the…”
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Outcomes of adults and children with primary mediastinal B‐cell lymphoma treated with dose‐adjusted EPOCH‐R by Giulino‐Roth, Lisa, O'Donohue, Tara, Chen, Zhengming, Bartlett, Nancy L., LaCasce, Ann, Martin‐Doyle, William, Barth, Matthew J., Davies, Kimberly, Blum, Kristie A., Christian, Beth, Casulo, Carla, Smith, Sonali M., Godfrey, James, Termuhlen, Amanda, Oberley, Matthew J., Alexander, Sarah, Weitzman, Sheila, Appel, Burton, Mizukawa, Benjamin, Svoboda, Jakub, Afify, Zeinab, Pauly, Melinda, Dave, Hema, Gardner, Rebecca, Stephens, Deborah M., Zeitler, William A., Forlenza, Christopher, Levine, Jennifer, Williams, Michael E., Sima, Jody L., Bollard, Catherine M., Leonard, John P.

“…Summary Treatment with dose‐adjusted EPOCH (etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone) chemotherapy and rituximab (DA‐EPOCH‐R) has…”
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Results from the Phase 1 Portion of a Trial of Oral Ixazomib Combined with Chemotherapy in Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoma in Children, Adolescents and Young Adults: A Report from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium by Schafer, Eric S., Chi, Yueh-Yun, Malvar, Jemily, Rushing, Teresa, Doan, Andrew, Pacenta, Holly L., Schore, Reuven J., Sposto, Richard, Leong, Roy, Gaynon, Paul S., Rubnitz, Jeffrey E., Barredo, Julio C., Slone, Tamra, Pauly, Melinda, Wayne, Alan S., Bhojwani, Deepa, Horton, Terzah M.

“…Proteasome inhibitors potentiate anti-tumor effects of standard cytotoxic chemotherapy in childhood leukemia. Ixazomib is an oral proteasome inhibitor that has…”
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Anti-Leukemic Activity of Luveltamab Tazevibulin (LT, STRO-002), a Novel Folate Receptor-α (FR-α)-Targeting Antibody Drug Conjugate (ADC) in Relapsed/Refractory CBF2AT3::GLIS2 AML by Williams, Robin, Miller, Lane, Massaro, Stephanie, Krieger, Elizabeth, Pauly, Melinda, Nelson, Catherine, Johnson, Rebecca, Welch, Jennifer J.G., Bhojwani, Deepa, Moghimi, Babak, Neff, Philip, Horton, Terzah M., Imran, Hamayun, Ribeiro, Raul C., Guinipero, Terri L., Kutny, Matthew A., Bautista, Felipe, Johnson, Amy, Lewing, Karen, Gamis, Alan S, Brackett, Julienne, McCall, David, Bhatla, Teena, Sulis, Maria Luisa, Tellinghuisen, Amy, Beck, Jill C., Meshinchi, Soheil

“…Introduction: CBFA2T3::GLIS2 (CBF-GLIS) is an oncogenic fusion associated with a lethal and highly refractory childhood myeloid leukemia manifested by the RAM…”
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Abstract PO-012: Clinical features and antibody response of two pediatric patients presenting with new-onset acute myeloid leukemia and concomitant severe COVID-19 by Patel, Pratik A., Rostad, Christina A., Lapp, Stacey A., Stokes, Claire L., Pauly, Melinda G., Anderson, Evan J., Sabnis, Himalee S.

“…Abstract Objective: SARS-CoV-2 infection has led to a worldwide pandemic of COVID-19 (coronavirus disease 2019), placing individuals with pre-existing medical…”
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A Pilot Study of Azacitidine As Epigenetic Priming for Chemotherapy in Infants Less Than 1 Year of Age with KMT2A-Rearranged Acute Lymphoblastic Leukemia (ALL); Results from the Children's Oncology Group (COG) Trial AALL15P1 by Guest, Erin, Kairalla, John, Devidas, Meenakshi, Hibbitts, Emily, Carroll, Andrew J., Heerema, Nyla A., Kubaney, Holly, August, Amanda, Pauly, Melinda, Wechsler, Daniel, Miles, Rodney R., Reid, Joel M., Kihei, Cynthia, Gore, Lia, Raetz, Elizabeth A., Hunger, Stephen P., Loh, Mignon L., Brown, Patrick A.

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Anti-Leukemic Activity of STRO-002 a Novel Folate Receptor-α (FR-α)-Targeting ADC in Relapsed/Refractory CBF2AT3-GLIS2 AML by Meshinchi, Soheil, Miller, Lane, Massaro, Stephanie, Williams, Robin, Krieger, Elizabeth, Pauly, Melinda, Nelson, Catherine, Bhojwani, Deepa, Johnson, Rebecca, Horton, Terzah M., Imran, Hamayun, Chang, Wen-I, Neff, Philip, Kutny, Matthew, Ribeiro, Raul C., Bautista, Felipe, Guinipero, Terri, Murray, Kate, Butte, Alex, Molina, Arturo

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Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) by Burke, Michael J., Ziegler, David S., Bautista Sirvent, Francisco José, Attarbaschi, Andishe, Gore, Lia, Locatelli, Franco, O'Brien, Maureen M, Pauly, Melinda, Obreja, Mihaela, Morris, Christopher L., Baruchel, Andre

“…▪ Salvage options for children with relapsed ALL remain sub-optimal, particularly for T-cell ALL patients, and relapse remains the leading cause of death…”
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Maintenance Treatment With Low-Dose Mercaptopurine in Combination With Allopurinol in Children With Acute Lymphoblastic Leukemia and Mercaptopurine-Induced Pancreatitis by Zerra, Patricia, Bergsagel, John, Keller, Frank G., Lew, Glen, Pauly, Melinda

“…Mercaptopurine (6‐mercaptopurine, 6MP) is a mainstay of curative therapy in childhood acute lymphoblastic leukemia (ALL), and contributes to its 90% overall…”
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Phase 1b study of carfilzomib with induction chemotherapy in pediatric relapsed/refractory acute lymphoblastic leukemia by Burke, Michael J., Ziegler, David S., Bautista, Francisco, Attarbaschi, Andishe, Gore, Lia, Locatelli, Franco, M. O'Brien, Maureen, Pauly, Melinda, Kormany, William N., Tian, Shengqi, Morris, Christopher L., Baruchel, Andre

“…Background Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Survival for patients following relapse remains poor, and…”
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Cryptic t(6;11) KMT2A rearrangement in a pediatric acute myeloid leukemia patient detected by next‐generation sequencing and dual‐fusion FISH analysis by Raghunandan, Sharmila, Jain, Juhi, Saxe, Debra, Pauly, Melinda, Aljudi, Ahmed A., Ketterling, Rhett P., Carter, Alexis B., Raikar, Sunil S.

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