Search Results - "Pauly, H."

Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy by Hiatt, Andrew, Bohorova, Natasha, Bohorov, Ognian, Goodman, Charles, Kim, Do, Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Piedra, Pedro A., Gilbert, Brian E., Zeitlin, Larry

“…Respiratory syncytial virus (RSV) can cause devastating lower respiratory tract infections in preterm infants or when other serious health problems are…”
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Transgenic resistance confers effective field level control of bacterial spot disease in tomato by Horvath, Diana M, Stall, Robert E, Jones, Jeffrey B, Pauly, Michael H, Vallad, Gary E, Dahlbeck, Doug, Staskawicz, Brian J, Scott, John W

“…We investigated whether lines of transgenic tomato (Solanum lycopersicum) expressing the Bs2 resistance gene from pepper, a close relative of tomato,…”
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Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail by Pettitt, James, Zeitlin, Larry, Kim, Do H, Working, Cara, Johnson, Joshua C, Bohorov, Ognian, Bratcher, Barry, Hiatt, Ernie, Hume, Steven D, Johnson, Ashley K, Morton, Josh, Pauly, Michael H, Whaley, Kevin J, Ingram, Michael F, Zovanyi, Ashley, Heinrich, Megan, Piper, Ashley, Zelko, Justine, Olinger, Gene G

“…Ebola virus (EBOV) remains one of the most lethal transmissible infections and is responsible for high fatality rates and substantial morbidity during sporadic…”
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Monoclonal antibody therapy for Junin virus infection by Zeitlin, Larry, Geisbert, Joan B., Deer, Daniel J., Fenton, Karla A., Bohorov, Ognian, Bohorova, Natasha, Goodman, Charles, Kim, Do, Hiatt, Andrew, Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Altmann, Friedrich, Gruber, Clemens, Steinkellner, Herta, Honko, Anna N., Kuehne, Ana I., Aman, M. Javad, Sahandi, Sara, Enterlein, Sven, Zhan, Xiaoguo, Enria, Delia, Geisbert, Thomas W.

“…Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the…”
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Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana by Swope, Kelsi, Morton, Josh, Pogue, Gregory P, Burden, Leigh, Partain, Nicholas, Hume, Steve, Shepherd, John, Simpson, Carrie A, Brennan, Miles B, Furman, Thomas C, Kingrey-Gebe, Sheila, Martinez, Theresa, McDonough, Jim, Pauly, Michael H, Whaley, Kevin J, Zeitlin, Larry, Bratcher, Barry, Haydon, Hugh

“…The ongoing SARS-CoV-2 coronavirus pandemic of 2020-2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb)…”
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Deleterious effects of osteoarthritis on the structure and function of the meniscal enthesis by Abraham, A.C, Pauly, H.M, Haut Donahue, T.L

“…Summary Objective The ability of menisci to prevent osteoarthritis (OA) is dependent on the integrity of the complex meniscal entheses, the attachments of the…”
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Mineralization of meniscal enthesis in osteoarthritic knees by Pauly, H, Abraham, A, Haut Donahue, T.L

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A Study of Acute and Chronic Tissue Changes in Surgical and Traumatically-Induced Experimental Models of Knee Joint Injury Using Magnetic Resonance Imaging and Micro-Computed Tomography by Fischenich, Kristine M, Pauly, Hannah M, Button, Keith D, Fajardo, Ryan S, DeCamp, Charles E, Haut, Roger C, Haut Donahue, Tammy L

“…Abstract Objective The objective of this study was to monitor the progression of joint damage in two animal models of knee joint trauma using two non-invasive,…”
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In utero nicotine exposure causes persistent, gender‐dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice by Pauly, James R., Sparks, Jae A., Hauser, Kurt F., Pauly, Thomas H.

“…Maternal cigarette smoking during pregnancy can result in a wide variety of adverse fetal outcomes, ranging from preterm delivery and low birth weight, to…”
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A Three-day Course of Dexamethasone Therapy to Prevent Chronic Lung Disease in Ventilated Neonates: A Randomized Trial by Garland, Jeffery S, Alex, Colleen P, Pauly, Thomas H, Whitehead, Vicki L, Brand, Joseph, Winston, James F, Samuels, David P, McAuliffe, Timothy L

“…Although several trials of early dexamethasone therapy have been completed to determine if such therapy would reduce mortality and chronic lung disease (CLD)…”
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Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp by Qiu, Xiangguo, Wong, Gary, Audet, Jonathan, Bello, Alexander, Fernando, Lisa, Alimonti, Judie B., Fausther-Bovendo, Hugues, Wei, Haiyan, Aviles, Jenna, Hiatt, Ernie, Johnson, Ashley, Morton, Josh, Swope, Kelsi, Bohorov, Ognian, Bohorova, Natasha, Goodman, Charles, Kim, Do, Pauly, Michael H., Velasco, Jesus, Pettitt, James, Olinger, Gene G., Whaley, Kevin, Xu, Bianli, Strong, James E., Zeitlin, Larry, Kobinger, Gary P.

“…Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These…”
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New real ternary and pseudoternary phases in the Li–Au–In system by Dmytriv, G.S., Pavlyuk, V.V., Pauly, H., Eckert, J., Ehrenberg, H.

“…Two real ternary lithium gold indides LiAu 2In and Li 280Au 22In 130 (Li 0.65Au 0.05In 0.30) were found in the Li–Au–In system. They are isostructural to the…”
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Polymorphism of LiAg by Pavlyuk, V.V., Dmytriv, G.S., Tarasiuk, I.I., Chumak, I.V., Pauly, H., Ehrenberg, H.

“…A phase transition from the cubic CsCl-type structure (Pm-3m space group) into a tetragonal UPb-type structure (I4 1/amd) is observed for the LiAg binary…”
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Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection by Wec, Anna Z., Bornholdt, Zachary A., He, Shihua, Herbert, Andrew S., Goodwin, Eileen, Wirchnianski, Ariel S., Gunn, Bronwyn M., Zhang, Zirui, Zhu, Wenjun, Liu, Guodong, Abelson, Dafna M., Moyer, Crystal L., Jangra, Rohit K., James, Rebekah M., Bakken, Russell R., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Bortz, Robert H., Whaley, Kevin J., Goldstein, Tracey, Anthony, Simon J., Alter, Galit, Walker, Laura M., Dye, John M., Zeitlin, Larry, Qiu, Xiangguo, Chandran, Kartik

“…Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails…”
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A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates by Bornholdt, Zachary A., Herbert, Andrew S., Mire, Chad E., He, Shihua, Cross, Robert W., Wec, Anna Z., Abelson, Dafna M., Geisbert, Joan B., James, Rebekah M., Rahim, Md Niaz, Zhu, Wenjun, Borisevich, Viktoriya, Banadyga, Logan, Gunn, Bronwyn M., Agans, Krystle N., Wirchnianski, Ariel S., Goodwin, Eileen, Tierney, Kevin, Shestowsky, William S., Bohorov, Ognian, Bohorova, Natasha, Velasco, Jesus, Ailor, Eric, Kim, Do, Pauly, Michael H., Whaley, Kevin J., Alter, Galit, Walker, Laura M., Chandran, Kartik, Zeitlin, Larry, Qiu, Xiangguo, Geisbert, Thomas W., Dye, John M.

“…Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable nature of ebolavirus reemergence and the urgent need for antiviral…”
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Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception by Shrestha, Bhawana, Vincent, Kathleen, Schaefer, Alison, Zhu, Yong, Vargas, Gracie, Motamedi, Massoud, Swope, Kelsi, Morton, Josh, Simpson, Carrie, Pham, Henry, Brennan, Miles B., Pauly, Michael H., Zeitlin, Larry, Bratcher, Barry, Whaley, Kevin J., Moench, Thomas R., Lai, Samuel K.

“…Nonhormonal products for on-demand contraception are a global health technology gap; this unmet need motivated us to pursue the use of sperm-binding monoclonal…”
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Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody by Mire, Chad E, Geisbert, Joan B, Borisevich, Viktoriya, Fenton, Karla A, Agans, Krystle N, Flyak, Andrew I, Deer, Daniel J, Steinkellner, Herta, Bohorov, Ognian, Bohorova, Natasha, Goodman, Charles, Hiatt, Andrew, Kim, Do H, Pauly, Michael H, Velasco, Jesus, Whaley, Kevin J, Crowe, Jr, James E, Zeitlin, Larry, Geisbert, Thomas W

“…As observed during the 2013-2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of…”
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The crystal structure of the LiAg2In compound by PAVLYUK, V. V, DMYTRIV, G. S, CHUMAK, I. V, EHRENBERG, H, PAULY, H

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Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody by Zeitlin, Larry, Cross, Robert W., Geisbert, Joan B., Borisevich, Viktoriya, Agans, Krystle N., Prasad, Abhishek N., Enterlein, Sven, Aman, M. Javad, Bornholdt, Zachary A., Brennan, Miles B., Campbell, Lioudmila, Kim, Do, Mlakar, Neil, Moyer, Crystal L., Pauly, Michael H., Shestowsky, William, Whaley, Kevin J., Fenton, Karla A., Geisbert, Thomas W.

“…The COVID-19 pandemic has reemphasized the need to identify safe and scalable therapeutics to slow or reverse symptoms of disease caused by newly emerging and…”
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Development of an antibody cocktail for treatment of Sudan virus infection by Herbert, Andrew S., Froude, Jeffery W., Ortiz, Ramon A., Kuehne, Ana I., Dorosky, Danielle E., Bakken, Russell R., Zak, Samantha E., Josleyn, Nicole M., Musiychuk, Konstantin, Jones, R. Mark, Green, Brian, Streatfield, Stephen J., Wec, Anna Z., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Stonier, Spencer W., Bornholdt, Zachary A., Chandran, Kartik, Zeitlin, Larry, Sampey, Darryl, Yusibov, Vidadi, Dye, John M.

“…Antibody-based therapies are a promising treatment option for managing ebolavirus infections. Several Ebola virus (EBOV)-specific and, more recently,…”
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