Search Results - "Paulussen, Jeannette J.C"

Effects of oxatomide and derivatives on high affinity IgE receptor-activated signal transduction pathways in rat basophilic leukemia cells: role of protein tyrosine hyperphosphorylation and inhibition of extracellular calcium influx by Paulussen, Jeannette J.C, Fischer, Marcel J.E, Roozendaal, Ramon L, van der Heijden, Vincent C, van Dijken, Peter, de Mol, Nico J, Janssen, Lambert H.M

“…The antiallergic drug oxatomide and analogs inhibit mediator release from a rat basophilic leukemia (RBL-2H3) cell line, which is frequently used as a mast…”
Get full text

Dual effect of the anti-allergic astemizole on Ca2+ fluxes in rat basophilic leukemia (RBL-2H3) cells : Release of Ca2+ from intracellular stores and inhibition of Ca2+ release-activated Ca2+ influx by FISCHER, M. J. E, PAULUSSEN, J. J. C, DE MOL, N. J, JANSSEN, L. H. M

“…The antiallergic drugs astemizole and norastemizole inhibit exocytosis in mast cells, which might be relevant for their therapeutic action. From previous…”
Get full text

REACH alternative testing strategy for skin sensitization in practice: Fact or fiction? by Barentsen, Helma M., Jonis, Simon U., Pelgrom, Sylvia M.G.J., Rijk, Jeroen C.W., Westerink, Walter M.A., Paulussen, Jeannette J.C.

“…From October 2016 the REACH Regulation requires an alternative testing strategy for skin sensitization. The current paper describes our experience when putting…”
Get full text

Structure-activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis by FISCHER, M. J. E, PAULUSSEN, J. J. C, TOLLENAERE, J. P, DE MOL, N. J, JANSSEN, L. H. M

“…The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme beta-hexosaminidase were studied in a mast cell model,…”
Get full text

Dual Effect of the Anti-Allergic Astemizole on Ca 2 Fluxes in Rat Basophilic Leukemia (RBL-2H3) Cells: Release of Ca 2 from Intracellular Stores and Inhibition of Ca 2 Release-Activated Ca 2 Influx by Fischer, Marcel J.E., Paulussen, Jeannette J.C., de Mol, Nico J., Janssen, Lambert H.M.

“…The antiallergic drugs astemizole and norastemizole inhibit exocytosis in mast cells, which might be relevant for their therapeutic action. From previous…”
Get full text

Structure–activity relationships of astemizole derivatives for inhibition of store operated Ca 2+ channels and exocytosis by Fischer, Marcel J.E., Paulussen, Jeannette J.C., Tollenaere, Jan P., De Mol, Nico J., Janssen, Lambert H.M.

“…The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme β-hexosaminidase were studied in a mast cell model,…”
Get full text

Influence of the antiallergic drug oxatomide and derivatives on membrane structures: relation with inhibition of calcium influx in rat basophilic leukemia cells by Paulussen, Jeannette J.C., Fischer, Marcel J.E., Zuidam, Nicolaas J., v. Miltenburg, J.Cees, de Mol, Nico J., Janssen, Lambert H.M.

“…Oxatomide is an H 1 antihistaminic drug that also inhibits mediator release from mast cells. From previous studies, it appeared that inhibition of the influx…”
Get full text

Influence of the anti-allergic drug oxatomide on the signal transduction mechanism in a mast cell model by Paulussen, Jeannette J.C., Fischer, Marcel J.E., Kok-Van Esterik, Jolien A.E., Tiemessen, Radboud C., De Mol, Nico J., Janssen, Lambert H.M.

“…In a mast cell model, oxatomide displays inhibition of mediator release which is not related to its histamine H 1 receptor antagonistic activity. From a…”
Get full text

Effects of the anti-allergics astemizole and norastemizole on FcεRI receptor-mediated signal transduction processes by Fischer, Marcel J.E, Paulussen, Jeannette J.C, Kok-Van Esterik, Jolien A.E, Van der Heijden, Vincent S, De Mol, Nico J, Janssen, Lambert H.M

“…The non-sedating anti-allergic drug astemizole, apart from its potential to antagonise H 1 receptors, inhibits the release of inflammation mediators from mast…”
Get full text

Oxatomide and derivatives as inhibitors of mediator release from a mast cell model. Structure-activity relationships by Paulussen, J J, Fischer, M J, Roelofsen, E P, Horbach, D A, de Mol, N J, Janssen, L H

“…A series of benzimidazolone and benzimidazole analogues of the antiallergic drug oxatomide (1-¿3-[4-(diphenylmethyl)-1-piperazinyl]propyl¿-1,3-dihydro-2H-…”
Get more information