Search Results - "Paulson, L."

Pathogenesis of SCA3 and implications for other polyglutamine diseases by McLoughlin, Hayley S., Moore, Lauren R., Paulson, Henry L.

“…Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine (polyQ) diseases, caused by CAG repeat expansions in the coding regions…”
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CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome by Todd, Peter K., Oh, Seok Yoon, Krans, Amy, He, Fang, Sellier, Chantal, Frazer, Michelle, Renoux, Abigail J., Chen, Kai-chun, Scaglione, K. Matthew, Basrur, Venkatesha, Elenitoba-Johnson, Kojo, Vonsattel, Jean P., Louis, Elan D., Sutton, Michael A., Taylor, J. Paul, Mills, Ryan E., Charlet-Berguerand, Nicholas, Paulson, Henry L.

“…Fragile X-associated tremor ataxia syndrome (FXTAS) results from a CGG repeat expansion in the 5′ UTR of FMR1. This repeat is thought to elicit toxicity as…”
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Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition by Martorell, Anthony J., Paulson, Abigail L., Suk, Ho-Jun, Abdurrob, Fatema, Drummond, Gabrielle T., Guan, Webster, Young, Jennie Z., Kim, David Nam-Woo, Kritskiy, Oleg, Barker, Scarlett J., Mangena, Vamsi, Prince, Stephanie M., Brown, Emery N., Chung, Kwanghun, Boyden, Edward S., Singer, Annabelle C., Tsai, Li-Huei

“…We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted…”
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Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics by Bakulski, Kelly M, Rozek, Laura S, Dolinoy, Dana C, Paulson, Henry L, Hu, Howard

“…Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD) is complex, with significant contributions from both genes and…”
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RNA-mediated neurodegeneration in repeat expansion disorders by Todd, Peter K., Paulson, Henry L.

“…Most neurodegenerative disorders are thought to result primarily from the accumulation of misfolded proteins, which interfere with protein homeostasis in…”
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Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice by McLoughlin, Hayley S., Moore, Lauren R., Chopra, Ravi, Komlo, Robert, McKenzie, Megan, Blumenstein, Kate G., Zhao, Hien, Kordasiewicz, Holly B., Shakkottai, Vikram G., Paulson, Henry L.

“…Objective Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. Despite advances in…”
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Polyglutamine neurodegeneration: protein misfolding revisited by Williams, Aislinn J, Paulson, Henry L

“…Polyglutamine diseases are a major cause of neurodegeneration worldwide. Recent studies highlight the importance of protein quality control mechanisms in…”
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Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP by Scaglione, K. Matthew, Zavodszky, Eszter, Todi, Sokol V., Patury, Srikanth, Xu, Ping, Rodríguez-Lebrón, Edgardo, Fischer, Svetlana, Konen, John, Djarmati, Ana, Peng, Junmin, Gestwicki, Jason E., Paulson, Henry L.

“…The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here we describe a series of molecular events that coordinately regulate…”
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Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia by McKay, Erin C, Beck, John S, Khoo, Sok Kean, Dykema, Karl J, Cottingham, Sandra L, Winn, Mary E, Paulson, Henry L, Lieberman, Andrew P, Counts, Scott E

“…Abstract Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive…”
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Alzheimer’s pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation by Prince, Stephanie M., Paulson, Abigail L., Jeong, Nuri, Zhang, Lu, Amigues, Solange, Singer, Annabelle C.

“…Synapse loss and altered synaptic strength are thought to underlie cognitive impairment in Alzheimer’s disease (AD) by disrupting neural activity essential for…”
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Associations of healthy lifestyle and socioeconomic status with cognitive function in U.S. older adults by Wang, Xin, Bakulski, Kelly M., Paulson, Henry L., Albin, Roger L., Park, Sung Kyun

“…We investigated the complex relations of socioeconomic status (SES) and healthy lifestyles with cognitive functions among older adults in 1313 participants,…”
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RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome by Oh, Seok Yoon, He, Fang, Krans, Amy, Frazer, Michelle, Taylor, J Paul, Paulson, Henry L, Todd, Peter K

“…Fragile X-associated tremor ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG trinucleotide repeat expansion in the 5' UTR of the Fragile…”
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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau by Blair, Laura J, Nordhues, Bryce A, Hill, Shannon E, Scaglione, K Matthew, O'Leary, 3rd, John C, Fontaine, Sarah N, Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L, Muschol, Martin, Uversky, Vladimir N, Klengel, Torsten, Binder, Elisabeth B, Kayed, Rakez, Golde, Todd E, Berchtold, Nicole, Dickey, Chad A

“…Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51,…”
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Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3 by Shakkottai, Vikram G, do Carmo Costa, Maria, Dell'Orco, James M, Sankaranarayanan, Ananthakrishnan, Wulff, Heike, Paulson, Henry L

“…The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the inherited ataxias, including the polyglutamine disease…”
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Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways by Idera, Akiko, Sharkey, Lisa M., Kurauchi, Yuki, Kadoyama, Keiichi, Paulson, Henry L., Katsuki, Hiroshi, Seki, Takahiro

“…Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation…”
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Estimating pathogen‐spillover risk using host–ectoparasite interactions by Brennan, Reilly N., Paulson, Sally L., Escobar, Luis E.

“…Pathogen spillover corresponds to the transmission of a pathogen or parasite from an original host species to a novel host species, preluding disease…”
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Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex by Bakulski, Kelly M, Dolinoy, Dana C, Sartor, Maureen A, Paulson, Henry L, Konen, John R, Lieberman, Andrew P, Albin, Roger L, Hu, Howard, Rozek, Laura S

“…Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimer's disease (LOAD), but little has been done on a genome-wide…”
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Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly by Sharkey, Lisa M., Safren, Nathaniel, Pithadia, Amit S., Gerson, Julia E., Dulchavsky, Mark, Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Kim, John H., Meliki, Alia, Minakawa, Eiko N., Barmada, Sami J., Ivanova, Magdalena I., Paulson, Henry L.

“…UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas…”
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siRNA-mediated gene silencing in vitro and in vivo by Davidson, Beverly L, Xia, Haibin, Mao, Qinwen, Paulson, Henry L

“…RNA interference is now established as an important biological strategy for gene silencing, but its application to mammalian cells has been limited by…”
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Evaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse Models by Moore, Lauren R., Rajpal, Gautam, Dillingham, Ian T., Qutob, Maya, Blumenstein, Kate G., Gattis, Danielle, Hung, Gene, Kordasiewicz, Holly B., Paulson, Henry L., McLoughlin, Hayley S.

“…The most common dominantly inherited ataxia, spinocerebellar ataxia type 3 (SCA3), is an incurable neurodegenerative disorder caused by a CAG repeat expansion…”
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