Search Results - "Pauls, Samantha D"

Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target by Pauls, Samantha D., Marshall, Aaron J.

“…The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity…”
Get full text

Distinct effects of α-linolenic acid and docosahexaenoic acid on the expression of genes related to cholesterol metabolism and the response to infection in THP-1 monocytes and immune cells of obese humans by Rodway, Lisa A., Pauls, Samantha D., Pascoe, Christopher D., Aukema, Harold M., Taylor, Carla G., Zahradka, Peter

“…Monocytes play a large role in chronic inflammatory conditions such as obesity, atherosclerosis and infection. Marine-derived omega-3 fatty acids such as…”
Get full text

The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions by Pauls, Samantha D, Lafarge, Sandrine T, Landego, Ivan, Zhang, Tingting, Marshall, Aaron J

“…The phosphoinositide 3-kinase (PI3K) pathway is a central signal transduction axis controlling normal B cell homeostasis and activation in humoral immunity…”
Get full text

Anti-inflammatory effects of α-linolenic acid in M1-like macrophages are associated with enhanced production of oxylipins from α-linolenic and linoleic acid by Pauls, Samantha D, Rodway, Lisa A, Winter, Tanja, Taylor, Carla G, Zahradka, Peter, Aukema, Harold M

“…Chronic inflammation, mediated in large part by proinflammatory macrophage populations, contributes directly to the induction and perpetuation of metabolic…”
Get full text

Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health by Pauls, Samantha D., Du, Youjia, Clair, Luc, Winter, Tanja, Aukema, Harold M., Taylor, Carla G., Zahradka, Peter

“…Cardiovascular disease, a major cause of mortality and morbidity, exhibits sexual dimorphism since the onset of cardiovascular disease occurs later in women…”
Get full text

Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile by Pauls, Samantha D., Rodway, Lisa A., Winter, Tanja, Taylor, Carla G., Zahradka, Peter, Aukema, Harold M.

“…Alternatively activated macrophages are innate immune cells that contribute to resolution of inflammation and maintenance of homeostasis. Modulation of…”
Get full text

SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells by Pauls, Samantha D., Hou, Sen, Marshall, Aaron J.

“…SH2 domain-containing inositol 5′-phosphatase (SHIP) has critical functions in regulating signal transduction. In additional to its lipid phosphatase activity,…”
Get full text

Oils Rich in α-Linolenic Acid or Docosahexaenoic Acid Have Distinct Effects on Plasma Oxylipin and Adiponectin Concentrations and on Monocyte Bioenergetics in Women with Obesity by Pauls, Samantha D, Rodway, Lisa R, Sidhu, Karanbir K, Winter, Tanja, Sidhu, Nikhil, Aukema, Harold M, Zahradka, Peter, Taylor, Carla G

“…Omega-3 fatty acids, including DHA and α-linolenic acid (ALA), are proposed to improve metabolic health by reducing obesity-associated inflammation. Their…”
Get more information

The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release by Hou, Sen, Pauls, Samantha D, Liu, Peimei, Marshall, Aaron J

“…Mast cell activation triggered by IgE binding to its high affinity receptor FcɛRI is highly dependent on signaling via phosphoinositde 3-kinases (PI3K). The…”
Get full text

Rationale and design of a randomized controlled trial examining the effects of marine- and plant-sourced omega-3 fatty acid supplements on octadecanoid profiles and inflammation in females with obesity (OXBIO trial) by Rodway, Lisa A, Pauls, Samantha D, Aukema, Harold M, Zahradka, Peter, Taylor, Carla G

“…•Rationale, design, and procedures of the OXBIO study.•A double-blind, cross-over study examining 4-week ALA and DHA supplementation.•Compares effects of n-3…”
Get full text

Spleen Oxylipin and Polyunsaturated Fatty Acid Profiles are Altered by Dietary Source of Polyunsaturated Fatty Acid and by Sex by Pauls, Samantha D., Ragheb, Mariam, Winter, Tanja, Leng, Shan, Taylor, Carla G., Zahradka, Peter, Aukema, Harold M.

“…As the largest secondary lymphoid organ, the spleen plays an important role in immune responses. The role of arachidonic acid (ARA) and its 20‐carbon…”
Get full text

FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells by Pauls, Samantha D, Ray, Arnab, Hou, Sen, Vaughan, Andrew T, Cragg, Mark S, Marshall, Aaron J

“…SHIP is an important regulator of immune cell signaling that functions to dephosphorylate the phosphoinositide phosphatidylinositol 3,4,5-trisphosphate at the…”
Get full text

Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex by Mendonça, Anne M., Cayer, Lucien G.J., Pauls, Samantha D., Winter, Tanja, Leng, Shan, Taylor, Carla G., Zahradka, Peter, Aukema, Harold M.

“…Dietary EPA and DHA given together alter oxylipins in adipose tissue. To compare the separate effects of individual dietary n-3 PUFA on oxylipins in different…”
Get full text

Adipose tissue oxylipin profiles vary by anatomical site and are altered by dietary linoleic acid in rats by Cayer, Lucien G.J., Mendonça, Anne M., Pauls, Samantha D., Winter, Tanja, Leng, Shan, Taylor, Carla G., Zahradka, Peter, Aukema, Harold M.

“…•Oxylipin profiles of four rat adipose depots were determined.•Depots differed in 20–22 carbon oxylipins from cytochrome P450 and cyclooxygenase.•Linoleic acid…”
Get full text

ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells by Lafarge, Sandrine T., Li, Hongzhao, Pauls, Samantha D., Hou, Sen, Johnston, James B., Gibson, Spencer B., Marshall, Aaron J.

Get full text

Differential expression and function of CD27 in chronic lymphocytic leukemia cells expressing ZAP-70 by Lafarge, Sandrine T, Hou, Sen, Pauls, Samantha D, Johnston, James B, Gibson, Spencer B, Marshall, Aaron J

“…Highlights • ZAP-70-positive CLL display higher expression of CD27 than ZAP-70-negative CLL. • CD27 levels are elevated upon BCR cross-linking, or upon ectopic…”
Get full text

Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health by Pauls, Samantha D., Du, Youjia, Clair, Luc, Winter, Tanja, Aukema, Harold M., Taylor, Carla G., Zahradka, Peter

Get full text

ZAP 70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells by Lafarge, Sandrine T., Li, Hongzhao, Pauls, Samantha D., Hou, Sen, Johnston, James B., Gibson, Spencer B., Marshall, Aaron J.

Get full text

The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain Fc[inline image]RI-induced calcium flux and granule release by Hou, Sen, Pauls, Samantha D, Liu, Peimei, Marshall, Aaron J

“…Mast cell activation triggered by IgE binding to its high affinity receptor Fc[inline image]RI is highly dependent on signaling via phosphoinositde 3-kinases…”
Get full text