Search Results - "Paulose, C.S."

Oxidative stress mediated neuronal damage in the corpus striatum of 6-hydroxydopamine lesioned Parkinson's rats: Neuroprotection by Serotonin, GABA and Bone Marrow Cells Supplementation by Kuruvilla, Korah P, Nandhu, M.S, Paul, Jes, Paulose, C.S

“…Abstract Oxidative stress-induced neuronal cell death has been implicated in Parkinson's disease (PD). Oxidative stress initiated by 6-hydroxydopamine (6-OHDA)…”
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NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: Ameliorating effects of curcumin by Jayanarayanan, S., Smijin, S., Peeyush, K.T., Anju, T.R., Paulose, C.S.

“…► Curcumin decreased blood glucose level in diabetes by enhancing serum insulin. ► Its antioxidant activity restored GPx expression, which resituated GLAST…”
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Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: restorative role of Withania somnifera by Anju, T R, Smijin, S, Jobin, M, Paulose, C S

“…Temporal lobe epilepsy involves a sequence of events that can lead to neurotransmitter signalling alterations. There are many herbal extracts considered to be…”
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Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats by Sherin, A, Anu, J, Peeyush, K.T, Smijin, S, Anitha, M, Roshni, B.T, Paulose, C.S

“…Abstract Neurotransmitter receptor functional regulation plays an important role in controlling the excitability and responsiveness of hippocampal neurons…”
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Striatal dopamine receptors modulate the expression of insulin receptor, IGF-1 and GLUT-3 in diabetic rats: Effect of pyridoxine treatment by Anitha, M., Abraham, Pretty Mary, Paulose, C.S.

“…The incidence of type 2 diabetes mellitus is rising at alarming proportions. Central nervous system plays an important part in orchestrating glucose…”
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Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats by Naijil, George, Anju, T.R, Jayanarayanan, S, Paulose, C.S

“…Abstract Lifestyle modification pivoting on nutritional management holds tremendous potential to meet the challenge of management of diabetes. The current…”
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Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: Antagonism by Bacopa monnieri by Krishnakumar, Amee, Nandhu, M.S, Paulose, C.S

“…Abstract Emotional disturbances, depressive mood, anxiety, aggressive behavior, and memory impairment are the common psychiatric features associated with…”
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Down-regulation of cerebellar 5-HT2C receptors in pilocarpine-induced epilepsy in rats: Therapeutic role of Bacopa monnieri extract by Krishnakumar, Amee, Abraham, Pretty Mary, Paul, Jes, Paulose, C.S

“…Abstract Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures. Cerebellar dysfunction is a…”
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Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: Ameliorating effects of Withania somnifera and withanolide A by Soman, Smijin, Anju, T.R, Jayanarayanan, S, Antony, Sherin, Paulose, C.S

“…Abstract The aim of this study was to investigate the effect of Withania somnifera (WS) extract, withanolide A (WA), and carbamazepine (CBZ) on cerebellar AMPA…”
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Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: Neuroprotective role of Bacopa monnieri extract by Khan, Reas, Krishnakumar, Amee, Paulose, C.S

“…Abstract The potential for antiepileptic drugs to negatively impact cognitive abilities has generated renewed interest in herbal drugs and formulations in the…”
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Down regulation of cerebellar serotonergic receptors in streptozotocin induced diabetic rats: Effect of pyridoxine and Aegle marmelose by Abraham, Pretty Mary, Paul, Jes, Paulose, C.S

“…Abstract Oxidative stress plays an important role in cerebellar damage caused by diabetes, leading to deterioration in glucose homeostasis causing metabolic…”
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3.240 DECREASED SEROTONERGIC RECEPTORS REGULATION IN 6-HYDROXYDOPAMINE LESIONED RATS: NEUROPROTECTION BY CO-MITOGENIC SEROTONIN AND GABA IN COMBINATION WITH BONE MARROWS CELLS by Korah, P.K, Paulose, C.S

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Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture by Gireesh, G., Thomas, Santhosh K., Joseph, Binoy, Paulose, C.S.

“…The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present study, the…”
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Cortical cholinergic dysregulation as a long-term consequence of neonatal hypoglycemia by Anju, T R, Paulose, C S

“…Neonatal hypoglycemia limits the glucose supply to cells, affecting the function of brain due to its high energy demand. This can cause long-term consequences…”
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Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats by Peeyush Kumar, T., Antony, Sherin, Soman, Smijin, Kuruvilla, Korah P., George, Naijil, Paulose, C.S.

“…Diabetes exacerbates neuronal injury mediated through neurotransmitters deregulation in cerebral cortex. Our study analyzed the neuroprotective effect of…”
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Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat by Chinthu, R, Anju, T R, Paulose, C S

“…Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical…”
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Targeting glutamate mediated excitotoxicity in huntington’s disease: Neural progenitors and partial glutamate antagonist – Memantine by Anitha, M, Nandhu, M.S, Anju, T.R, Jes, P, Paulose, C.S

“…Summary Huntington’s disease (HD) is a fatal progressive neurodegenerative disorder with autosomal dominant inheritance. In humans mutated huntingtin (htt)…”
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Oxidative stress and cell death in the cerebral cortex as a long-term consequence of neonatal hypoglycemia by Anju, T R, Akhilraj, P R, Paulose, C S

“…Neonatal hypoglycemia limits glucose supply to cells leading to long-term consequences in brain function. The present study evaluated antioxidant and cell…”
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Striatal cholinergic functional alterations in hypoxic neonatal rats: role of glucose, oxygen, and epinephrine resuscitation by Anju, T R, Paulose, C S

“…Molecular processes regulating cholinergic functions play an important role in the control of respiration under hypoxia. Cholinergic alterations and its…”
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Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats by Joseph, A, Antony, S, Paulose, C.S

“…Abstract Hypoglycemia causes brain fuel deprivation, resulting in functional brain failure and brain death. It is a serious complication of insulin therapy in…”
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