Search Results - "Paulo, Ivo"

Molecular mechanisms of ROS production and oxidative stress in diabetes by Newsholme, Philip, Cruzat, Vinicius Fernandes, Keane, Kevin Noel, Carlessi, Rodrigo, de Bittencourt, Jr, Paulo Ivo Homem

“…Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an…”
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Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction by Homem de Bittencourt, Paulo Ivo, Carlessi, Rodrigo, Cruzat, Vinicius Fernandes, Keane, Kevin N., Newsholme, Philip

“…The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress…”
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The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management by Homem de Bittencourt, Paulo Ivo, Newsholme, Philip, Scomazzon, Sofia Pizzato, Bittencourt, Aline, Heck, Thiago Gomes, Krause, Mauricio, Curi, Rui

“…Recent evidence shows divergence between the concentrations of extracellular 70 kDa heat shock protein [eHSP70] and its intracellular concentrations [iHSP70]…”
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Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia by Cruzat, Vinicius Fernandes, Ph.D, Bittencourt, Aline, B.Ph.Ed, Scomazzon, Sofia Pizzato, B.Biomed, Leite, Jaqueline Santos Moreira, B.Nutr, de Bittencourt, Paulo Ivo Homem, Ph.D, Tirapegui, Julio, Ph.D

“…Abstract Objective The aim of the present study was to determine the effects of oral supplementation with l -glutamine plus l -alanine (GLN+ALA), both in the…”
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The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch by Schroeder, Helena Trevisan, De Lemos Muller, Carlos Henrique, Heck, Thiago Gomes, Krause, Mauricio, de Bittencourt, Paulo Ivo Homem

“…The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges…”
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The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes by Krause, Mauricio, Bock, Patricia Martins, Takahashi, Hilton Kenji, Homem De Bittencourt, Jr, Paulo Ivo, Newsholme, Philip

“…The 70 kDa heat-shock protein (HSP70) family is important for a dynamic range of cellular processes that include protection against cell stress, modulation of…”
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Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response by Miragem, Antônio Azambuja, Homem de Bittencourt, Jr, Paulo Ivo

“…Although some unequivocal underlying mechanisms of menopausal hot flushes have been demonstrated in animal models, the paucity of similar approaches in humans…”
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Obesity depresses the anti‐inflammatory HSP70 pathway, contributing to NAFLD progression by Cangeri Di Naso, Fábio, Rosa Porto, Rossana, Sarubbi Fillmann, Henrique, Maggioni, Lucas, Vontobel Padoin, Alexandre, Jacques Ramos, Rafael, Corá Mottin, Claudio, Bittencourt, Aline, Anair Possa Marroni, Norma, Ivo Homem de Bittencourt, Paulo

“…Objectives To evaluate whether reduced activity of the anti‐inflammatory HSP70 pathway correlates with nonalcoholic fatty liver disease (NAFLD) progression and…”
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GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation by Carlessi, Rodrigo, Chen, Younan, Rowlands, Jordan, Cruzat, Vinicius F., Keane, Kevin N., Egan, Lauren, Mamotte, Cyril, Stokes, Rebecca, Gunton, Jenny E., Bittencourt, Paulo Ivo Homem de, Newsholme, Philip

“…Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by…”
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Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial by Farinha, Juliano B., Ramis, Thiago R., Vieira, Alexandra F., Macedo, Rodrigo C.O., Rodrigues-Krause, Josianne, Boeno, Francesco P., Schroeder, Helena T., Müller, Carlos Henrique, Boff, Winston, Krause, Maurício, De Bittencourt, Paulo Ivo H., Reischak-Oliveira, Alvaro

“…To investigate the effects of high-intensity interval training (HIIT) and/or strength training (ST) on inflammatory, oxidative stress (OS) and glycemic…”
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Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice by Bruxel, Maciel Alencar, Tavares, Angela Maria Vicente, Zavarize Neto, Luiz Domingues, de Souza Borges, Victor, Schroeder, Helena Trevisan, Bock, Patricia Martins, Rodrigues, Maria Inês Lavina, Belló-Klein, Adriane, Homem de Bittencourt, Paulo Ivo

“…Unhealthy lifestyle persistently feeds forward inflammation in metabolic organs thus imposing senescence-associated secretory phenotype (SASP), as observed in…”
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Regulatory principles in metabolism-then and now by Curi, Rui, Newsholme, Philip, Marzuca-Nassr, Gabriel Nasri, Takahashi, Hilton Kenji, Hirabara, Sandro Massao, Cruzat, Vinicius, Krause, Mauricio, de Bittencourt, Jr, Paulo Ivo Homem

“…The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years…”
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Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR) by Schroeder, Helena Trevisan, De Lemos Muller, Carlos Henrique, Heck, Thiago Gomes, Krause, Mauricio, de Bittencourt, Paulo Ivo Homem

“…Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition…”
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Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies by Heck, Thiago Gomes, Ludwig, Mirna Stela, Frizzo, Matias Nunes, Rasia-Filho, Alberto Antonio, Homem de Bittencourt, Paulo Ivo

“…The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common…”
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HPOSS: A hierarchical portfolio optimization stacking strategy to reduce the generalization error of ensembles of models by Ozelim, Luan Carlos de Sena Monteiro, Ribeiro, Dimas Betioli, Schiavon, José Antonio, Domingues, Vinicius Resende, Queiroz, Paulo Ivo Braga de

“…Surrogate models are frequently used to replace costly engineering simulations. A single surrogate is frequently chosen based on previous experience or by…”
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Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases by Schroeder, Helena Trevisan, De Lemos Muller, Carlos Henrique, Heck, Thiago Gomes, Krause, Mauricio, de Bittencourt, Paulo Ivo Homem

“…The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions…”
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Comparison of two bias correction methods for precipitation simulated with a regional climate model by Tschöke, Gabriele Vanessa, Kruk, Nadiane Smaha, de Queiroz, Paulo Ivo Braga, Chou, Sin Chan, de Sousa Junior, Wilson Cabral

“…This study evaluates the performance of two bias correction techniques—power transformation and gamma distribution adjustment—for Eta regional climate model…”
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Subacute Effects of Moderate-Intensity Aerobic Exercise in the Fasted State on Cell Metabolism and Signaling in Sedentary Rats by Ayres, Layane Ramos, Vogt, Éverton Lopes, Schroeder, Helena Trevisan, Russo, Mariana Kras Borges, Von Dentz, Maiza Cristina, Rocha, Débora Santos, Model, Jorge Felipe Argenta, Kowalewski, Lucas Stahlhöfer, de Souza, Samir Khal, de Oliveira Girelli, Vitória, da Rosa Coelho, Jerônimo, de Souza Vargas, Nathalia, Reischak-Oliveira, Alvaro, de Bittencourt, Jr, Paulo Ivo Homem, Wilhelm, Eurico Nestor, Vinagre, Anapaula Sommer, Krause, Mauricio

“…Physical inactivity induces insulin resistance (IR) and metabolic imbalances before any significant changes in adiposity. Recent studies suggest that the…”
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Heat shock response to exercise in pancreatic islets of obese mice by Bittencourt, Aline, Schroeder, Helena Trevisan, Porto, Rossana Rosa, de Lemos Muller, Carlos Henrique, Krause, Mauricio, Homem de Bittencourt, Paulo Ivo

“…Chronic obesity imposes an organismal state of low-grade inflammation because the physiological resolution of inflammation is progressively repressed giving…”
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Comparative study on the influence of the content and functionalization of alginate matrices on K-562 cell viability and differentiation by Morais, Everton C., Schroeder, Helena T., Souza, Cristina S., Rodrigues, Silvia R., Rodrigues, Maria Ines L., de Bittencourt, Paulo Ivo Homem, Santos, João Henrique Z. Dos

“…Microencapsulation of functioning cells for transplantation therapies is particularly promising, but the cells must retain their proper physiology and…”
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