Search Results - "Paulo, G"

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ by Banks, Alexander S., McAllister, Fiona E., Camporez, João Paulo G., Zushin, Peter-James H., Jurczak, Michael J., Laznik-Bogoslavski, Dina, Shulman, Gerald I., Gygi, Steven P., Spiegelman, Bruce M.

“…Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ. Role…”
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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice by Camporez, João-Paulo G., Petersen, Max C., Abudukadier, Abulizi, Moreira, Gabriela V., Jurczak, Michael J., Friedman, Glenn, Haqq, Christopher M., Petersen, Kitt Falk, Shulman, Gerald I.

“…Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and pathophysiological processes, including normal aging. There are…”
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The Chemistry and Applications of Metal–Organic Frameworks (MOFs) as Industrial Enzyme Immobilization Systems by Silva, Allison, Alexandre, Jeferson, Souza, José, Neto, José, de Sousa Júnior, Paulo, Rocha, Maria, dos Santos, José

“…Enzymatic biocatalysis is a sustainable technology. Enzymes are versatile and highly efficient biocatalysts, and have been widely employed due to their…”
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Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo by Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I.

“…Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis…”
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Osseointegration of metallic devices: Current trends based on implant hardware design by Coelho, Paulo G., Jimbo, Ryo

“…•Critical review of bone healing related to implant hardware.•Bone healing is remarkably affected by implant macrodesign and surgical drilling.•Multiple…”
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Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids by Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.

“…A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance—wherein insulin fails to suppress hepatic glucose…”
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Radiographer research in radiation protection: National and European perspectives by Paulo, G.

“…The author of this paper gives an overview about the evolution of radiography education in Portugal and reflects about the importance of Radiographer-led…”
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Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance by Camporez, João Paulo G, Jornayvaz, François R, Lee, Hui-Young, Kanda, Shoichi, Guigni, Blas A, Kahn, Mario, Samuel, Varman T, Carvalho, Carla R.O, Petersen, Kitt Falk, Jurczak, Michael J, Shulman, Gerald I

“…Estrogen replacement therapy reduces the incidence of type 2 diabetes in postmenopausal women; however, the mechanism is unknown. Therefore, the aim of this…”
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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice by Camporez, João Paulo G, Jornayvaz, François R, Petersen, Max C, Pesta, Dominik, Guigni, Blas A, Serr, Julie, Zhang, Dongyan, Kahn, Mario, Samuel, Varman T, Jurczak, Michael J, Shulman, Gerald I

“…Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid metabolism and is currently being pursued as a therapeutic agent for insulin…”
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Thermo‐Responsive MOF/Polymer Composites for Temperature‐Mediated Water Capture and Release by Karmakar, Avishek, Mileo, Paulo G. M., Bok, Ivan, Peh, Shing Bo, Zhang, Jian, Yuan, Hongye, Maurin, Guillaume, Zhao, Dan

“…We report an in situ polymerization strategy to incorporate a thermo‐responsive polymer, poly(N‐isopropylacrylamide) (PNIPAM), with controlled loadings into…”
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Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales by Coelho, Paulo G, Jimbo, Ryo, Tovar, Nick, Bonfante, Estevam A

“…Highlights • Atemporal osseointegration would improve patient's function and quality of life. • Accelerating/improving osseointegration demands combined and…”
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Achieving Superprotonic Conduction with a 2D Fluorinated Metal–Organic Framework by Mileo, Paulo G. M, Adil, Karim, Davis, Louisa, Cadiau, Amandine, Belmabkhout, Youssef, Aggarwal, Himanshu, Maurin, Guillaume, Eddaoudi, Mohamed, Devautour-Vinot, Sabine

“…A hydrolytically stable metal–organic framework (MOF) material, named KAUST-7′, was derived from a structural phase change of KAUST-7 upon exposure to…”
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Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes by Perry, Rachel J., Camporez, João-Paulo G., Kursawe, Romy, Titchenell, Paul M., Zhang, Dongyan, Perry, Curtis J., Jurczak, Michael J., Abudukadier, Abulizi, Han, Myoung Sook, Zhang, Xian-Man, Ruan, Hai-Bin, Yang, Xiaoyong, Caprio, Sonia, Kaech, Susan M., Sul, Hei Sook, Birnbaum, Morris J., Davis, Roger J., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I.

“…Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major role in the pathogenesis of type 2 diabetes (T2D), yet the molecular…”
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Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch by Cohen, Paul, Levy, Julia D., Zhang, Yingying, Frontini, Andrea, Kolodin, Dmitriy P., Svensson, Katrin J., Lo, James C., Zeng, Xing, Ye, Li, Khandekar, Melin J., Wu, Jun, Gunawardana, Subhadra C., Banks, Alexander S., Camporez, João Paulo G., Jurczak, Michael J., Kajimura, Shingo, Piston, David W., Mathis, Diane, Cinti, Saverio, Shulman, Gerald I., Seale, Patrick, Spiegelman, Bruce M.

“…A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here, we show that…”
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Clinical benefit and radiological response with BRAF inhibitor in a patient with recurrent ameloblastoma harboring V600E mutation by Fernandes, Gustavo S, Girardi, Daniel M, Bernardes, João Paulo G, Fonseca, Felipe P, Fregnani, Eduardo R

“…Ameloblastoma is a slow-growing neoplasm of the jaw, for which the standard treatment is surgical removal of the lesion with high recurrence rates and elevated…”
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A controlled‐release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice by Abulizi, Abudukadier, Perry, Rachel J., Camporez, João Paulo G., Jurczak, Michael J., Petersen, Kitt Falk, Aspichueta, Patricia, Shulman, Gerald I.

“…ABSTRACT Lipodystrophy is a rare disorder characterized by complete or partial loss of adipose tissue. Patients with lipodystrophy exhibit…”
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Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo by Galbo, Thomas, Perry, Rachel J., Jurczak, Michael J., Camporez, João-Paulo G., Alves, Tiago C., Kahn, Mario, Guigni, Blas A., Serr, Julle, Zhang, Dongyan, Bhanot, Sanjay, Samuel, Varman T., Shulman, Gerald I.

“…Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and molecular mechanisms responsible for its pathogenesis remain…”
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Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance by Rahimi, Yasmeen, Camporez, João-Paulo G., Petersen, Max C., Pesta, Dominik, Perry, Rachel J., Jurczak, Michael J., Cline, Gary W., Shulman, Gerald I.

“…The pyruvate dehydrogenase complex (PDH) has been hypothesized to link lipid exposure to skeletal muscle insulin resistance through a glucose-fatty acid cycle…”
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Tracing the evolution of the plant meiotic molecular machinery by Thangavel, Gokilavani, Hofstatter, Paulo G., Mercier, Raphaël, Marques, André

“…Meiosis is a highly conserved specialised cell division in sexual life cycles of eukaryotes, forming the base of gene reshuffling, biological diversity and…”
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Classification of osseointegrated implant surfaces: materials, chemistry and topography by Dohan Ehrenfest, David M, Coelho, Paulo G, Kang, Byung-Soo, Sul, Young-Taeg, Albrektsson, Tomas

“…Since the founding of the osseointegration concept, the characteristics of the interface between bone and implant, and possible ways to improve it, have been…”
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