Search Results - "Paull, Jeremy"

Structure activity relationship of dendrimer microbicides with dual action antiviral activity by Tyssen, David, Henderson, Scott A, Johnson, Adam, Sterjovski, Jasminka, Moore, Katie, La, Jennifer, Zanin, Mark, Sonza, Secondo, Karellas, Peter, Giannis, Michael P, Krippner, Guy, Wesselingh, Steve, McCarthy, Tom, Gorry, Paul R, Ramsland, Paul A, Cone, Richard, Paull, Jeremy R A, Lewis, Gareth R, Tachedjian, Gilda

“…Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly…”
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A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose‑ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis by Waldbaum, Arthur S, Schwebke, Jane R, Paull, Jeremy R A, Price, Clare F, Edmondson, Stephanie R, Castellarnau, Alex, McCloud, Philip, Kinghorn, George R

“…Astodrimer Gel contains a novel dendrimer intended to treat and prevent bacterial vaginosis. We assessed the efficacy and safety of Astodrimer Gel for…”
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Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial by Castellarnau, Alex, Heery, Graham P., Seta, Aynaz, Luscombe, Carolyn A., Kinghorn, George R., Button, Peter, McCloud, Philip, Paull, Jeremy R. A.

“…Astodrimer sodium is a dendrimer molecule with antiviral and virucidal activity against SARS-CoV-2 and other respiratory viruses in vitro, and has previously…”
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SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans by Price, Clare F, Tyssen, David, Sonza, Secondo, Davie, Ashley, Evans, Sonya, Lewis, Gareth R, Xia, Shirley, Spelman, Tim, Hodsman, Peter, Moench, Thomas R, Humberstone, Andrew, Paull, Jeremy R A, Tachedjian, Gilda

“…SPL7013 Gel (VivaGel(®)) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral…”
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Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium by Paull, Jeremy R. A., Luscombe, Carolyn A., Seta, Aynaz, Heery, Graham P., Bobardt, Michael D., Gallay, Philippe A., Constant, Samuel, Castellarnau, Alex

“…COVID-19 remains a severe condition for many including immunocompromised individuals. There remains a need for effective measures against this and other…”
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A phase I randomized placebo controlled trial of the safety of 3% SPL7013 Gel (VivaGel®) in healthy young women administered twice daily for 14 days by Cohen, Craig R, Brown, Joelle, Moscicki, Anna-Barbara, Bukusi, Elizabeth A, Paull, Jeremy R A, Price, Clare F, Shiboski, Stephen

“…To assess the safety of VivaGel® used vaginally twice daily for 14 days among healthy, sexually-abstinent women, aged 18-24 years in the USA and Kenya…”
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Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1 by Telwatte, Sushama, Moore, Katie, Johnson, Adam, Tyssen, David, Sterjovski, Jasminka, Aldunate, Muriel, Gorry, Paul R., Ramsland, Paul A., Lewis, Gareth R., Paull, Jeremy R.A., Sonza, Secondo, Tachedjian, Gilda

“…Topical microbicides for use by women to prevent the transmission of human immunodeficiency virus (HIV) and other sexually transmitted infections are urgently…”
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Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro by Paull, Jeremy R.A., Heery, Graham P., Bobardt, Michael D., Castellarnau, Alex, Luscombe, Carolyn A., Fairley, Jacinth K., Gallay, Philippe A.

“…An effective response to the ongoing coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will…”
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Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model by Romanowski, Eric G, Yates, Kathleen A, Paull, Jeremy R A, Heery, Graham P, Shanks, Robert M Q

“…There is no approved antiviral therapy for adenovirus (HAdV) ocular infections. Astodrimer sodium (SPL7013) is a polyanionic dendrimer with antiviral activity…”
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Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice by Paull, Jeremy R. A., Luscombe, Carolyn A., Castellarnau, Alex, Heery, Graham P., Bobardt, Michael D., Gallay, Philippe A.

“…Strategies to combat COVID-19 require multiple ways to protect vulnerable people from infection. SARS-CoV-2 is an airborne pathogen and the nasal cavity is a…”
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Safety, Tolerability, and Pharmacokinetics of SPL7013 Gel (VivaGel®): A Dose Ranging, Phase I Study by O'Loughlin, John, Millwood, Iona Y., McDonald, Helen M., Price, Clare F., Kaldor, John M., Paull, Jeremy R. A.

“…Objectives: To evaluate safety, tolerability and systemic pharmacokinetics of escalating doses of SPL7013 Gel in healthy women. Design: Randomized,…”
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Astodrimer Sodium Nasal Spray versus Placebo in Non-Hospitalised Patients with COVID-19: A Randomised, Double-Blinded, Placebo-Controlled Trial by Winchester, Stephen, Castellarnau, Alex, Jabbar, Kashif, Nadir, Meera, Ranasinghe, Kapila, Masramon, Xavier, Kinghorn, George R, John, Isaac, Paull, Jeremy R A

“…Dendrimer-based astodrimer sodium nasal spray was assessed for its ability to reduce SARS-CoV-2 load in outpatients with COVID-19, which remains a severe…”
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Two phase 3, double-blind, placebo-controlled studies of the efficacy and safety of Astodrimer 1% Gel for the treatment of bacterial vaginosis by Chavoustie, Steven E., Carter, Belvia A., Waldbaum, Arthur S., Donders, Gilbert G.G., Peters, Klaus H., Schwebke, Jane R., Paull, Jeremy R.A., Price, Clare F., Castellarnau, Alex, McCloud, Philip, Kinghorn, George R.

“…Astodrimer is a dendrimer formulated in a vaginal gel to treat bacterial vaginosis (BV) and prevent recurrence. The objective of these studies was to confirm…”
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Dendrimers as Drugs:  Discovery and Preclinical and Clinical Development of Dendrimer-Based Microbicides for HIV and STI Prevention by McCarthy, Tom D., Karellas, Peter, Henderson, Scott A., Giannis, Michael, O'Keefe, David F., Heery, Graham, Paull, Jeremy R. A., Matthews, Barry R., Holan, George

“…Starpharma focuses on the use of dendrimers as drugs in their own right, in contrast to dendrimers as drug delivery vehicles or diagnostics. This contextual…”
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A phase 3, randomized, controlled trial of Astodrimer 1% Gel for preventing recurrent bacterial vaginosis by Schwebke, Jane R., Carter, Belvia A., Waldbaum, Arthur S., Agnew, Kathy J., Paull, Jeremy R.A., Price, Clare F., Castellarnau, Alex, McCloud, Philip, Kinghorn, George R.

“…•Recurrent bacterial vaginosis impacts on women and carries a high financial burden.•Astodrimer 1% Gel was superior to placebo for prevention of recurrent…”
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Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides by SONZA, Secondo, JOHNSON, Adam, TYSSEN, David, SPELMAN, Tim, LEWIS, Gareth R, PAULL, Jeremy R. A, TACHEDJIAN, Gilda

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Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides by LACKMAN-SMITH, Carol, OSTERLING, Clay, WATSON, Karen M, CUMMINS, James E, SANDERS-BEER, Brigitte E, LUCKENBAUGH, Katherine, MANKOWSKI, Marie, SNYDER, Beth, LEWIS, Gareth, PAULL, Jeremy, PROFY, Albert, PTAK, Roger G, BUCKHEIT, Robert W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Formulating a Sulfonated Antiviral Dendrimer in a Vaginal Microbicidal Gel Having Dual Mechanisms of Action by Mumper, Russell J., Bell, Michael A., Worthen, David R., Cone, Richard A., Lewis, Gareth R., Paull, Jeremy R. A., Moench, Thomas R.

“…SPL7013 is the sodium salt of a sulfonated dendrimer that has potent antiviral properties. VivaGel®, a topical gel containing 3% (wt wt) SPL7013, is in…”
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Restraint Stress: Differential Cardiovascular Responses in Wistar-Kyoto and Spontaneously Hypertensive Rats by McDougall, Stuart J, Paull, Jeremy R. A, Widdop, Robert E, Lawrence, Andrew J

“…With the use of a restraint stress paradigm, both normotensive Wistar-Kyoto (WKY ) rats and spontaneously hypertensive rats (SHR) underwent acute (1-hour…”
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A Randomized Controlled Trial of the Safety of Candidate Microbicide SPL7013 Gel When Applied to the Penis by Chen, Marcus Y, Millwood, Iona Y, Wand, Handan, Poynten, Mary, Law, Matthew, Kaldor, John M, Wesselingh, Steve, Price, Clare F, Clark, Laura J, Paull, Jeremy R A, Fairley, Christopher K

“…OBJECTIVES:To determine the safety of the candidate vaginal microbicide SPL7013 gel (VivaGel) when applied to the penis. METHODS:A randomized, double-blind,…”
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