Search Results - "Paule, M G"

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys by Paule, M.G, Li, M, Allen, R.R, Liu, F, Zou, X, Hotchkiss, C, Hanig, J.P, Patterson, T.A, Slikker,, W, Wang, C

“…Abstract Previously our laboratory has shown that ketamine exposure (24 h of clinically relevant anesthesia) causes significant increases in neuronal cell…”
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Gene expression profiling in the developing rat brain exposed to ketamine by Shi, Q, Guo, L, Patterson, T.A, Dial, S, Li, Q, Sadovova, N, Zhang, X, Hanig, J.P, Paule, M.G, Slikker, W, Wang, C

“…Abstract Ketamine, a non-competitive N-methyl- d -aspartate (NMDA) receptor antagonist, is associated with accelerated neuronal apoptosis in the developing…”
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The effects of l -carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex by Zou, X, Sadovova, N, Patterson, T.A, Divine, R.L, Hotchkiss, C.E, Ali, S.F, Hanig, J.P, Paule, M.G, Slikker, W, Wang, C

“…Abstract The anesthetic gas nitrous oxide (N2 O) and the volatile anesthetic isoflurane (ISO) are commonly used in surgical procedures for human infants and in…”
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Discontinuation of methylphenidate after long-term exposure in nonhuman primates by Zhang, X., Berridge, M.S., Apana, S.M., Slikker, W., Paule, M.G., Talpos, John

“…Attention-deficit hyperactivity disorder (ADHD) is a common human neurobehavioral disorder that usually begins in early childhood. Methylphenidate (MPH) has…”
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Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey by Slikker, William, Zou, Xiaoju, Hotchkiss, Charlotte E., Divine, Rebecca L., Sadovova, Natalya, Twaddle, Nathan C., Doerge, Daniel R., Scallet, Andrew C., Patterson, Tucker A., Hanig, Joseph P., Paule, Merle G., Wang, Cheng

“…Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death…”
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MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates by Zhang, X., Talpos, J., Berridge, M.S., Apana, S.M., Slikker, W., Wang, C., Paule, M.G.

“…Methylphenidate (MPH) is a psychostimulant approved by the FDA to treatment Attention-Deficit Hyperactivity Disorder (ADHD). MPH is believed to exert its…”
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Response sequence difficulty in an incremental repeated acquisition (learning) procedure by Wright, L.K.M., Paule, M.G.

“…Incremental repeated acquisition (IRA) procedures require subjects to learn a different sequence of behavioral responses during each experimental session with…”
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Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity by Zhang, X, Liu, F, Slikker, W, Wang, C, Paule, M.G

“…Abstract The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly…”
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Behavioral effects associated with chronic ketamine or remacemide exposure in rats by Wright, L.K.M, Pearson, E.C, Hammond, T.G, Paule, M.G

“…Abstract The effects of chronic exposure to ketamine or remacemide on the acquisition and performance of food-reinforced operant behaviors was assessed in…”
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Effect of chronic MK-801 and/or phenytoin on the acquisition of complex behaviors in rats by Wright, L.K.M, Popke, E.J, Allen, R.R, Pearson, E.C, Hammond, T.G, Paule, M.G

“…Abstract The purpose of the present experiment was to assess the effects of chronic MK-801 (an N-methyl-D-aspartate receptor antagonist) and/or phenytoin (a…”
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Differential effects of two NMDA receptor antagonists on cognitive–behavioral performance in young nonhuman primates II by Popke, E.J, Allen, R.R, Pearson, E.C, Hammond, T.G, Paule, M.G

“…The present experiment examined the effects of chronic exposure to remacemide (an NMDA antagonist that also blocks fast sodium channels) or MK-801 (which…”
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Operant test battery performance in children : Correlation with IQ by PAULE, M. G, CHELONIS, J. J, BUFFALO, E. A, BLAKE, D. J, CASEY, P. H

“…The relationship between intelligence and money-(nickel-)reinforced operant behaviors were compared in 115 six year old children. The Operant Test Battery…”
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MicroPET/CT assessment of FDG uptake in brain after long-term methylphenidate treatment in nonhuman primates by Zhang, X, Newport, G.D, Callicott, R, Liu, S, Thompson, J, Berridge, M.S, Apana, S.M, Slikker, W, Wang, C, Paule, M.G

“…Abstract Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term…”
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Differential effects of two NMDA receptor antagonists on cognitive–behavioral development in nonhuman primates I by Popke, E.J, Allen, R.R, Pearson, E.C, Hammond, T.G, Paule, M.G

“…The present experiment examined effects of chronic exposure to remacemide (an N-methyl- d-aspartate [NMDA] antagonist which also blocks fast sodium channels)…”
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The use of timing behaviors in animals and humans to detect drug and/or toxicant effects by PAULE, M. G, MECK, W. H, MCMILLAN, D. E, MCCLURE, G. Y. H, BATESON, M, POPKE, E. J, CHELONIS, J. J, HINTON, S. C

“…Behavioral paradigms applicable for use in both human and nonhuman subjects for investigating aspects of timing behavior are presented with a view towards…”
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Effects of Acute Nicotine on Several Operant Behaviors in Rats by Popke, E.Jon, Mayorga, A.J, Fogle, Charles M, Paule, Merle G

“…The present experiment assessed nicotine's effects on complex cognitive processes using a variety of operant tasks in rats, including incremental repeated…”
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Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats by Mayorga, Arthur J, Popke, E.Jon, Fogle, C.Matthew, Paule, Merle G

“…Methylphenidate and d-amphetamine are central nervous system stimulants that have been suggested to share certain behavioral and neurochemical effects. The…”
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Assessing the potential toxicity of MK-801 and remacemide:: Chronic exposure in juvenile rhesus monkeys by Popke, E.J, Patton, R, Newport, G.D, Rushing, L.G, Fogle, C.M, Allen, R.R, Pearson, E.C, Hammond, T.G, Paule, M.G

“…The present experiment examined the effects of chronic exposure to either 0.1 or 1.0 mg/kg MK-801 [a selective N-methyl- d-aspartate (NMDA) receptor…”
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MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH by Zhang, X., Paule, M. G., Newport, G. D., Sadovova, N., Berridge, M. S., Apana, S. M., Kabalka, G., Miao, W., Slikker, W., Wang, Cheng

“…Recent reports indicate that 6–12 h of ketamine anesthesia can trigger neuronal apoptosis in postnatal day (PND) 7 rats. In vitro, ex vivo, and confocal…”
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Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia by Liu, F., Zou, X., Sadovova, N., Zhang, X., Shi, L., Guo, L., Qian, F., Wen, Z., Patterson, T.A., Hanig, J.P., Paule, M.G., Slikker, W., Wang, C.

“…Repeated administration of phencyclidine (PCP), an N-methyl- d-aspartate (NMDA) receptor antagonist, during development, may result in neuronal damage that…”
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