Search Results - "Paulauskis, JD"

Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations by Myrand, SP, Sekiguchi, K, Man, MZ, Lin, X, Tzeng, R‐Y, Teng, C‐H, Hee, B, Garrett, M, Kikkawa, H, Lin, C‐Y, Eddy, SM, Dostalik, J, Mount, J, Azuma, J, Fujio, Y, Jang, I‐J, Shin, S‐G, Bleavins, MR, Williams, JA, Paulauskis, JD, Wilner, KD

“…Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors…”
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Endocytosis of Ultrafine Particles by A549 Cells by Stearns, Rebecca C, Paulauskis, Joseph D, Godleski, John J

“…Alveolar epithelium's capacity to ingest inhaled ultrafine particles is not well characterized. The objectives of this study were to use an in vitro model of…”
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Assessment of fixatives, fixation, and tissue processing on morphology and RNA integrity by Cox, Melissa L., Schray, Carrie L., Luster, Chandra N., Stewart, Zachary S., Korytko, Peter J., M. Khan, Kanwar Nasir, Paulauskis, Joseph D., Dunstan, Robert W.

“…Molecular characterization of morphologic change requires exquisite tissue morphology and RNA preservation; however, traditional fixatives usually result in…”
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Neutrophil C5a receptor and the outcome in a rat model of sepsis by Guo, Ren-Feng, Riedemann, Niels C., Bernacki, Kurt D., Sarma, Vidya J., Laudes, Ines J., Reuben, Jayne S., Younkin, Ellen M., Neff, Thomas A., Paulauskis, Joseph D., Zetoune, Firas S., Ward, Peter A.

“…Complement fragment 5a (C5a)–C5a receptor (C5aR) signaling plays an essential role in neutrophil innate immunity. Blockade of either the ligand or the receptor…”
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Differential Ability of Transition Metals to Induce Pulmonary Inflammation by Rice, Timothy M., Clarke, Robert W., Godleski, John J., Al-Mutairi, Eiman, Jiang, Nan-Fei, Hauser, Russ, Paulauskis, Joseph D.

“…Transition metals are components of airborne particles and have been implicated in adverse health effects. The relative inflammatory potential of these metals…”
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Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation by Frevert, CW, Huang, S, Danaee, H, Paulauskis, JD, Kobzik, L

“…Expression of mRNA for the neutrophil (PMN) chemokine, KC, in rat models of lung injury suggests a role for this chemokine in pulmonary inflammation. We…”
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Altered Neutrophil Trafficking During Sepsis by Guo, Ren-Feng, Riedemann, Niels C, Laudes, Ines J, Sarma, Vidya J, Kunkel, Robin G, Dilley, Kari A, Paulauskis, Joseph D, Ward, Peter A

“…In sepsis, dysregulation of the inflammatory system is well known, as reflected in excessive inflammatory mediator production, complement activation, and…”
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Differential screening identifies genetic markers of monocyte to macrophage maturation by Krause, Stefan W., Rehli, Michael, Kreutz, Marina, Schwarzfischer, Lucia, Paulauskis, Joseph D., Andreesen, Reinhard

“…Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a…”
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Regulation of Macrophage Inflammatory Protein-1α mRNA by Oxidative Stress (∗) by Shi, Michael Ming, Godleski, John J., Paulauskis, Joseph D.

“…Accumulation of inflammatory cells within the lung has been implicated in oxidative injury. Recruitment of these cells to a tissue site is a complex process…”
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Concentration- and Time-dependent Upregulation and Release of the Cytokines MIP-2, KC, TNF, and MIP-1 α in Rat Alveolar Macrophages by Fungal Spores Implicated in Airway Inflammation by Shahan, Tracy A., Sorenson, W. G., Paulauskis, Joseph D., Morey, Roger, Lewis, Daniel M.

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Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation by Huang, S, Paulauskis, JD, Godleski, JJ, Kobzik, L

“…This study sought to test the hypothesis that expression of mRNA for two cytokines, macrophage inflammatory protein-2 (MIP-2) and the KC gene product, is…”
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In Vitro Efficacy of Morpholino-modified Antisense Oligomers Directed against Tumor Necrosis Factor-α mRNA by Taylor, Margaret Flynn, Paulauskis, Joseph D., Weller, Dwight D., Kobzik, Lester

“…Chemical modification of antisense oligonucleotides to increase nuclease resistance may improve their efficacy within enzyme-rich cellular targets (e.g…”
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Influence of matrix application timing on spectral reproducibility and quality in SELDI-TOF-MS by Jock, Carissa A, Paulauskis, Joseph D, Baker, David, Olle, Eric, Bleavins, Michael R, Johnson, Kent J, Heard, Pamela L

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Regulation of macrophage inflammatory protein‐2 gene expression by oxidative stress in rat alveolar macrophages by Shi, M M, Chong, I, Godleski, J J, Paulauskis, J D

“…Chemokines are important mediators in the development of inflammation. Our previous work demonstrated that an oxidative stress can up‐regulate mRNA expression…”
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Rat alveolar macrophages express preprotachykinin gene-I mRNA-encoding tachykinins by Killingsworth, C R, Shore, S A, Alessandrini, F, Dey, R D, Paulauskis, J D

“…Although the tachykinins substance P (SP) and neurokinin A have been largely localized to neurons, eosinophils have also been shown to express these peptides…”
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Mediating Phosphorylation Events in the Vanadium-Induced Respiratory Burst of Alveolar Macrophages by Grabowski, Gregory M., Paulauskis, Joseph D., Godleski, John J.

“…Occupational exposure by inhalation to vanadium-containing particles such as residual oil fly ash results in respiratory tract inflammation. This inflammation,…”
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Hormonal Regulation of Mouse Fatty Acid Synthase Gene Transcription in Liver by Paulauskis, J D, Sul, H S

“…Blot analysis of poly(A+) RNA showed a rapid and dramatic insulin induction of fatty acid synthase (FAS) mRNA in diabetic mouse liver. Insulin administration…”
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Induction of High Mobility Group-I(Y) Protein by Endotoxin and Interleukin-1 beta in Vascular Smooth Muscle Cells: Role in Activation of Inducible Nitric Oxide Synthase by Pellacani, A, Chin, M T, Wiesel, P, Ibanez, M, Patel, A, Yet, S, Hsieh, C, Paulauskis, J D, Reeves, R, Lee, M, Perrella, MA

“…Nonhistone chromosomal proteins of the high mobility group (HMG) affect the transcriptional regulation of certain mammalian genes. For example, HMG-I(Y)…”
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Vanadium-Induced Chemokine mRNA Expression and Pulmonary Inflammation by Pierce, Lisa M., Alessandrini, Francesca, Godleski, John J., Paulauskis, Joseph D.

“…Occupational exposure to vanadium is common in petrochemical, mining, steel, and utilities industries and results in toxic effects largely confined to the…”
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16S rRNA Restriction Fragment Length Polymorphism Analysis of Bacterial Diversity as a Biomarker of Ecological Health in Polluted Sediments from New Bedford Harbor, Massachusetts, USA by Sorci, Jonathan J., Paulauskis, Joseph D., Ford, Timothy E.

“…A polymerase chain reaction (PCR)-based method was developed to compare bacterial diversity among environmental sites with varying degrees of anthropogenic…”
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