Search Results - "Paul Simons, J"

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology by Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia

“…The development of new therapies to slow down or halt the progression of Parkinson’s disease is a health care priority. A key pathological feature is the…”
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Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway by Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Paul Simons, J, Lovestone, Simon

“…Although the mechanism of Aβ action in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increase the expression of the…”
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Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis by Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul

“…Cardiac ATTR amyloidosis, a serious but much under-diagnosed form of cardiomyopathy, is caused by deposition of amyloid fibrils derived from the plasma protein…”
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Pathogenetic mechanisms of amyloid A amyloidosis by Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.

“…Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited…”
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C‐reactive protein is essential for innate resistance to pneumococcal infection by Paul Simons, J., Loeffler, Jutta M., Al‐Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L., Tennent, Glenys A., Petrie, Aviva, Raynes, John G., Souza, J. Brian, Lawrence, Rachel A., Read, Kevin D., Pepys, Mark B.

“…Summary No deficiency of human C‐reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not…”
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Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia

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Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells by Lopes da Silva, Mafalda, O'Connor, Marie N, Kriston-Vizi, Janos, White, Ian J, Al-Shawi, Raya, Simons, J Paul, Mössinger, Julia, Haucke, Volker, Cutler, Daniel F

“…Weibel-Palade bodies (WPBs) are endothelial storage organelles that mediate the release of molecules involved in thrombosis, inflammation and angiogenesis,…”
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A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo by Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio

“…Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of…”
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Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity by Kimura, Atsuko, Stevenson, Paula L., Carter, Roderick N., MacColl, Gavin, French, Karen L., Paul Simons, J., Al-Shawi, Raya, Kelly, Valerie, Chapman, Karen E., Holmes, Megan C.

“…The 5‐HT2C receptor has been implicated in mood and eating disorders. In general, it is accepted that 5‐HT2C receptor agonists increase anxiety behaviours and…”
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Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin by Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio

“…To form extracellular aggregates, amyloidogenic proteins bypass the intracellular quality control, which normally targets unfolded/aggregated polypeptides…”
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Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo by Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.

“…Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid…”
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Oligonucleotide-mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression by Disterer, Petra, Papaioannou, Ioannis, Evans, Vanessa C., Paul Simons, J., Owen, James S.

“…Background Single‐stranded DNA oligonucleotides (ssODNs) can introduce small, specific sequence alterations into genomes. Potential applications include…”
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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al‐Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El‐Andaloussi, Samir, Alvarez‐Erviti, Lydia

“…ABSTRACT Alpha‐synuclein (α‐Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson's disease…”
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Antibody-Associated Reversal of ATTR Amyloidosis–Related Cardiomyopathy by Fontana, Marianna, Gilbertson, Janet, Verona, Guglielmo, Riefolo, Mattia, Slamova, Ivana, Leone, Ornella, Rowczenio, Dorota, Botcher, Nicola, Ioannou, Adam, Patel, Rishi K., Razvi, Yousuf, Martinez-Naharro, Ana, Whelan, Carol J., Venneri, Lucia, Duhlin, Amanda, Canetti, Diana, Ellmerich, Stephan, Moon, James C., Kellman, Peter, Al-Shawi, Raya, McCoy, Laura, Simons, J. Paul, Hawkins, Philip N., Gillmore, Julian D.

“…The investigators describe antibodies that bound amyloid in three patients with transthyretin amyloidosis. Spontaneous regression of cardiomyopathy occurred in…”
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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Papaioannou, Ioannis, Owen, James S., Simons, J. Paul

“…Cardiovascular disease is the leading worldwide cause of death. Apolipoprotein E (ApoE) is a 34-kDa circulating glycoprotein, secreted by the liver and…”
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Reducing β-Amyloid by Inhibition of BACE1 : How Low Should You Go? by Killick, Richard, Hardy, John, Simons, J. Paul

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Novel defect in phosphatidylinositol 4‐kinase type 2‐alpha (PI4K2A) at the membrane‐enzyme interface is associated with metabolic cutis laxa by Mohamed, Miski, Gardeitchik, Thatjana, Balasubramaniam, Shanti, Guerrero‐Castillo, Sergio, Dalloyaux, Daisy, Kraaij, Sanne, Venselaar, Hanka, Hoischen, Alexander, Urban, Zsolt, Brandt, Ulrich, Al‐Shawi, Raya, Simons, J. Paul, Frison, Michele, Ngu, Lock‐Hock, Callewaert, Bert, Spelbrink, Hans, Kallemeijn, Wouter W., Aerts, Johannes M. F. G., Waugh, Mark G., Morava, Eva, Wevers, Ron A.

“…Inherited cutis laxa, or inelastic, sagging skin is a genetic condition of premature and generalised connective tissue ageing, affecting various elastic…”
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Exon Skipping of Hepatic APOB Pre-mRNA With Splice-switching Oligonucleotides Reduces LDL Cholesterol In Vivo by Disterer, Petra, Al-Shawi, Raya, Ellmerich, Stephan, Waddington, Simon N, Owen, James S, Simons, J Paul, Khoo, Bernard

“…Familial hypercholesterolemia (FH) is a genetic disorder characterized by extremely high levels of plasma low-density lipoprotein (LDL), due to defective LDL…”
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The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons by Guha, Isa, Slamova, Ivana, Chun, Soyon, Clegg, Arthur, Golos, Michal, Thrasivoulou, Chris, Simons, J. Paul, Al-Shawi, Raya

“…Abstract During the course of normal aging, certain populations of nerve growth factor (NGF)-responsive neurons become selectively vulnerable to cell death…”
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Oligonucleotide-directed gene-editing technology: mechanisms and future prospects by Papaioannou, Ioannis, Simons, J Paul, Owen, James S

“…Gene editing, as defined here, uses short synthetic oligonucleotides to introduce small, site-specific changes into mammalian genomes, including repair of…”
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