Search Results - "Paul Proost"

Pathological roles of the homeostatic chemokine CXCL12 by Janssens, Rik, Struyf, Sofie, Proost, Paul

“…[Display omitted] •CXCL12, CXCR4 and ACKR3 have crucial homeostatic properties, as the respective knock-out animals are non-viable.•CXCL12, CXCR4 and ACKR3 are…”
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Chemokine-Induced Macrophage Polarization in Inflammatory Conditions by Ruytinx, Pieter, Proost, Paul, Van Damme, Jo, Struyf, Sofie

“…Macrophages represent a heterogeneous cell population and are known to display a remarkable plasticity. In response to distinct micro-environmental stimuli,…”
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Targeting Chemokine-Glycosaminoglycan Interactions to Inhibit Inflammation by Crijns, Helena, Vanheule, Vincent, Proost, Paul

“…Leukocyte migration into tissues depends on the activity of chemokines that form concentration gradients to guide leukocytes to a specific site. Interaction of…”
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Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands by Metzemaekers, Mieke, Vanheule, Vincent, Janssens, Rik, Struyf, Sofie, Proost, Paul

“…The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC…”
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Role of Defensins in Tumor Biology by Adyns, Lowie, Proost, Paul, Struyf, Sofie

“…Defensins have long been considered as merely antimicrobial peptides. Throughout the years, more immune-related functions have been discovered for both the…”
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Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria by Vågesjö, Evelina, Öhnstedt, Emelie, Mortier, Anneleen, Lofton, Hava, Huss, Fredrik, Proost, Paul, Roos, Stefan, Phillipson, Mia

“…Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Immune cells play important roles in wound healing by…”
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Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases by Opdenakker, Ghislain, Proost, Paul, Van Damme, Jo

“…Diagnosis and treatment of autoimmunity has mainly relied on adaptive immunity. Infection and inflammation induce cytokines and chemokines and activate myeloid…”
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Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages by Wauters, Els, Van Mol, Pierre, Garg, Abhishek Dinkarnath, Jansen, Sander, Van Herck, Yannick, Vanderbeke, Lore, Bassez, Ayse, Boeckx, Bram, Malengier-Devlies, Bert, Timmerman, Anna, Van Brussel, Thomas, Van Buyten, Tina, Schepers, Rogier, Heylen, Elisabeth, Dauwe, Dieter, Dooms, Christophe, Gunst, Jan, Hermans, Greet, Meersseman, Philippe, Testelmans, Dries, Yserbyt, Jonas, Tejpar, Sabine, De Wever, Walter, Matthys, Patrick, Neyts, Johan, Wauters, Joost, Qian, Junbin, Lambrechts, Diether

“…How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell…”
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Neutrophils: a cornerstone of liver ischemia and reperfusion injury by Oliveira, Thiago Henrique Caldeira de, Marques, Pedro Elias, Proost, Paul, Teixeira, Mauro Martins M

“…Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft rejection after liver transplantation. During IRI, an intense…”
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CD26/dipeptidylpeptidase IV—chemokine interactions: double‐edged regulation of inflammation and tumor biology by Mortier, Anneleen, Gouwy, Mieke, Van Damme, Jo, Proost, Paul, Struyf, Sofie

“…Review of how chemokine processing by CD26/DPP IV regulates leukocyte trafficking. Post‐translational modification of chemokines is an essential regulatory…”
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CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis by Vermeersch, Gael, Proost, Paul, Struyf, Sofie, Gouwy, Mieke, Devos, Timothy

“…BCR::ABL1 negative myeloproliferative neoplasms (MPN) form a distinct group of hematologic malignancies characterized by sustained proliferation of cells from…”
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Regulation of Chemokine Activity - A Focus on the Role of Dipeptidyl Peptidase IV/CD26 by Metzemaekers, Mieke, Van Damme, Jo, Mortier, Anneleen, Proost, Paul

“…Chemokines are small, chemotactic proteins that play a crucial role in leukocyte migration and are, therefore, essential for proper functioning of the immune…”
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The unique structural and functional features of CXCL12 by Janssens, Rik, Struyf, Sofie, Proost, Paul

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Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis by Vandendriessche, Sofie, Cambier, Seppe, Proost, Paul, Marques, Pedro E

“…The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously…”
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Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis by Malengier-Devlies, Bert, Metzemaekers, Mieke, Wouters, Carine, Proost, Paul, Matthys, Patrick

“…Neutrophils are key pathogen exterminators of the innate immune system endowed with oxidative and non-oxidative defense mechanisms. More recently, a more…”
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Regioselective Hydrolysis of Human Serum Albumin by ZrIV-Substituted Polyoxotungstates at the Interface of Positively Charged Protein Surface Patches and Negatively Charged Amino Acid Residues by Stroobants, Karen, Absillis, Gregory, Moelants, Eva, Proost, Paul, Parac-Vogt, Tatjana N.

“…Complexes comprising the Lewis acidic ZrIV metal and protein binding polyoxotungstate ligands of Lindqvist‐, Keggin‐ and Wells–Dawson‐type were found to region…”
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Highly Amino Acid Selective Hydrolysis of Myoglobin at Aspartate Residues as Promoted by Zirconium(IV)-Substituted Polyoxometalates by Ly, Hong Giang T., Absillis, Gregory, Janssens, Rik, Proost, Paul, Parac-Vogt, Tatjana N.

“…SDS‐PAGE/Edman degradation and HPLC MS/MS showed that zirconium(IV)‐substituted Lindqvist‐, Keggin‐, and Wells–Dawson‐type polyoxometalates (POMs) selectively…”
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Effect of posttranslational processing on the in vitro and in vivo activity of chemokines by Mortier, Anneleen, Gouwy, Mieke, Van Damme, Jo, Proost, Paul

“…The CXC and CC chemokine gene clusters provide an abundant number of chemotactic factors selectively binding to shared G protein-coupled receptors (GPCR)…”
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Polyoxometalates as a Novel Class of Artificial Proteases: Selective Hydrolysis of Lysozyme under Physiological pH and Temperature Promoted by a Cerium(IV) Keggin-Type Polyoxometalate by Stroobants, Karen, Moelants, Eva, Ly, Hong Giang T., Proost, Paul, Bartik, Kristin, Parac-Vogt, Tatjana N.

“…Hen‐egg‐white lysozyme (HEWL) is specifically cleaved at the Trp28–Val29 and Asn44–Arg45 peptide bonds in the presence of a Keggin‐type [Ce(α‐PW11O39)2]10−…”
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Reported Cases and Diagnostics of Occupational Insect Allergy: A Systematic Review by Ganseman, Eva, Gouwy, Mieke, Bullens, Dominique M A, Breynaert, Christine, Schrijvers, Rik, Proost, Paul

“…A significant part of adult-onset asthma is caused by occupational exposure to both high- and low-molecular-mass agents. Insects are occasionally described to…”
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