Search Results - "Paul Jank"

DNA methylation-based classification of sinonasal tumors by Jurmeister, Philipp, Glöß, Stefanie, Roller, Renée, Leitheiser, Maximilian, Schmid, Simone, Mochmann, Liliana H., Payá Capilla, Emma, Fritz, Rebecca, Dittmayer, Carsten, Friedrich, Corinna, Thieme, Anne, Keyl, Philipp, Jarosch, Armin, Schallenberg, Simon, Bläker, Hendrik, Hoffmann, Inga, Vollbrecht, Claudia, Lehmann, Annika, Hummel, Michael, Heim, Daniel, Haji, Mohamed, Harter, Patrick, Englert, Benjamin, Frank, Stephan, Hench, Jürgen, Paulus, Werner, Hasselblatt, Martin, Hartmann, Wolfgang, Dohmen, Hildegard, Keber, Ursula, Jank, Paul, Denkert, Carsten, Stadelmann, Christine, Bremmer, Felix, Richter, Annika, Wefers, Annika, Ribbat-Idel, Julika, Perner, Sven, Idel, Christian, Chiariotti, Lorenzo, Della Monica, Rosa, Marinelli, Alfredo, Schüller, Ulrich, Bockmayr, Michael, Liu, Jacklyn, Lund, Valerie J., Forster, Martin, Lechner, Matt, Lorenzo-Guerra, Sara L., Hermsen, Mario, Johann, Pascal D., Agaimy, Abbas, Seegerer, Philipp, Koch, Arend, Heppner, Frank, Pfister, Stefan M., Jones, David T. W., Sill, Martin, von Deimling, Andreas, Snuderl, Matija, Müller, Klaus-Robert, Forgó, Erna, Howitt, Brooke E., Mertins, Philipp, Klauschen, Frederick, Capper, David

“…The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities…”
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Nodal lymphangiogenesis and immunophenotypic variations of sinus endothelium in sentinel and non-sentinel lymph nodes of invasive breast carcinoma by Westhoff, Christina C, Müller, Sabrina K, Jank, Paul, Kalder, Matthias, Moll, Roland

“…Several studies have demonstrated the de novo formation of lymphatic vessels or the reorganization of lymphatic sinus in tumor-draining lymph nodes, partly…”
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How VEGF-A and its splice variants affect breast cancer development – clinical implications by Al Kawas, Hivin, Saaid, Inas, Jank, Paul, Westhoff, Christina C., Denkert, Carsten, Pross, Therese, Weiler, Karoline Barbara Stephanie, Karsten, Maria Margarete

“…Background Altered expression levels and structural variations in the vascular endothelial growth factor (VEGF) have been found to play important roles in…”
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Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial by Loibl, Sibylle, Treue, Denise, Budczies, Jan, Weber, Karsten, Stenzinger, Albrecht, Schmitt, Wolfgang D, Weichert, Wilko, Jank, Paul, Furlanetto, Jenny, Klauschen, Frederick, Karn, Thomas, Pfarr, Nicole, von Minckwitz, Gunter, Möbs, Markus, Jackisch, Christian, Sers, Christine, Schneeweiss, Andreas, Fasching, Peter A, Schem, Christian, Hummel, Michael, van Mackelenbergh, Marion, Nekljudova, Valentina, Untch, Michael, Denkert, Carsten

“…Next-generation sequencing (NGS) can be used for comprehensive investigation of molecular events in breast cancer. We evaluated the relevance of genomic…”
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Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer by Hoffmann, Inga, Dragomir, Mihnea P., Monjé, Nanna, Keunecke, Carlotta, Kunze, Catarina Alisa, Schallenberg, Simon, Marchenko, Sofya, Schmitt, Wolfgang D., Kulbe, Hagen, Sehouli, Jalid, Braicu, Ioana Elena, Jank, Paul, Denkert, Carsten, Darb-Esfahani, Silvia, Horst, David, Sinn, Bruno V., Sers, Christine, Bischoff, Philip, Taube, Eliane T.

“…The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays a crucial role in regulating the immune system's response to tumors, but its exact role in cancer,…”
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Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network by Sehouli, Jalid, Braicu, Elena Ioana, Richter, Rolf, Denkert, Carsten, Jank, Paul, Jurmeister, Philipp Sebastian, Kunze, Catarina Alisa, Budczies, Jan, Darb-Esfahani, Sylvia, Schmitt, Wolfgang Daniel, Traut, Alexander, Grabowski, Jacek, Taube, Eliane Tabea, Plett, Helmut

“…Low-grade serous ovarian carcinoma (LGSOC) has recently come up as a distinct rare entity of epithelial ovarian cancer. Predictive and prognostic markers are…”
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Polycomb Protein BMI-1 as a Potential Therapeutic Target in Mucinous Ovarian Cancer by Abobaker, Salem, Kulbe, Hagen, Taube, Eliane T, Darb-Esfahani, Silvia, Richter, Rolf, Denkert, Carsten, Jank, Paul, Sehouli, Jalid, Braicu, Elena Ioana

“…Mucinous ovarian carcinoma (mOC) is a rare subtype with distinct clinical characteristics and biological behavior that differentiate them from other epithelial…”
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Characterization of Hormone Receptor and HER2 Status in Breast Cancer Using Mass Spectrometry Imaging by Gonçalves, Juliana Pereira Lopes, Bollwein, Christine, Noske, Aurelia, Jacob, Anne, Jank, Paul, Loibl, Sibylle, Nekljudova, Valentina, Fasching, Peter A, Karn, Thomas, Marmé, Frederik, Müller, Volkmar, Schem, Christian, Sinn, Bruno Valentin, Stickeler, Elmar, van Mackelenbergh, Marion, Schmitt, Wolfgang D, Denkert, Carsten, Weichert, Wilko, Schwamborn, Kristina

“…Immunohistochemical evaluation of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 status stratify the different subtypes…”
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MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial by Jank, Paul, Gehlhaar, Claire, Bianca, Lederer, Caterina, Fontanella, Andreas, Schneeweiss, Karn, Thomas, Marmé, Frederik, Sinn, Hans-Peter, van Mackelenbergh, Marion, Sinn, Bruno, Zahm, Dirk-Michael, Ingold-Heppner, Barbara, Schem, Christian, Stickeler, Elmar, Fasching, Peter A, Nekljudova, Valentina, Taube, Eliane Tabea, Heppner, Frank, Müller, Volkmar, Denkert, Carsten, Loibl, Sibylle

“…Triple-negative breast cancer (TNBC) is typically treated with chemotherapeutic agents, including carboplatin (Cb), an DNA platinating agent. The…”
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Correction: MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial by Jank, Paul, Gehlhaar, Claire, Lederer, Bianca, Fontanella, Caterina, Schneeweiss, Andreas, Karn, Thomas, Marmé, Frederik, Sinn, Hans-Peter, van Mackelenbergh, Marion, Sinn, Bruno, Zahm, Dirk-Michael, Ingold-Heppner, Barbara, Schem, Christian, Stickeler, Elmar, Fasching, Peter A, Nekljudova, Valentina, Taube, Eliane Tabea, Heppner, Frank, Müller, Volkmar, Denkert, Carsten, Loibl, Sibylle

“…[This corrects the article DOI: 10.1371/journal.pone.0238021.]…”
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High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma by Jank, Paul, Leichsenring, Jonas, Kolb, Svenja, Hoffmann, Inga, Bischoff, Philip, Kunze, Catarina Alisa, Dragomir, Mihnea P, Gleitsmann, Moritz, Jesinghaus, Moritz, Schmitt, Wolfgang D, Kulbe, Hagen, Sers, Christine, Stenzinger, Albrecht, Sehouli, Jalid, Braicu, Ioana Elena, Westhoff, Christina, Horst, David, Denkert, Carsten, Gröschel, Stefan, Taube, Eliane T

“…Mechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß pathway, are…”
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Neuroendocrine Differentiation in Conventional Colorectal Adenocarcinomas: Incidental Finding or Prognostic Biomarker? by Konukiewitz, Björn, Kasajima, Atsuko, Schmitt, Maxime, Schwamborn, Kristina, Groll, Tanja, Schicktanz, Felix, Delbridge, Claire, Schütze, Lisa Marie, Wilhelm, Dirk, Lang, Corinna, Lange, Sebastian, Foersch, Sebastian, Jank, Paul, Steiger, Katja, Werder, Alexander von, Denkert, Carsten, Weichert, Wilko, Klöppel, Günter, Jesinghaus, Moritz

“…Background: Colorectal mixed adenoneuroendocrine carcinomas (MANECs) are clinically highly aggressive neoplasms. MANECs are composed of variable adenocarcinoma…”
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High expression of insulinoma‐associated protein 1 ( INSM1 ) distinguishes colorectal mixed and pure neuroendocrine carcinomas from conventional adenocarcinomas with diffuse expression of synaptophysin by Litmeyer, Anne‐Sophie, Konukiewitz, Björn, Kasajima, Atsuko, Foersch, Sebastian, Schicktanz, Felix, Schmitt, Maxime, Kellers, Franziska, Grass, Albert, Jank, Paul, Lehman, Bettina, Gress, Thomas M, Rinke, Anja, Bartsch, Detlef K, Denkert, Carsten, Weichert, Wilko, Klöppel, Günter, Jesinghaus, Moritz

“…Abstract Complementary to synaptophysin and chromogranin A, insulinoma‐associated protein 1 (INSM1) has emerged as a sensitive marker for the diagnosis of…”
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What turns CREB on? And off? And why does it matter? by Steven, André, Friedrich, Michael, Jank, Paul, Heimer, Nadine, Budczies, Jan, Denkert, Carsten, Seliger, Barbara

“…Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer…”
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Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis by Li, Zheqi, Wu, Yang, Yates, Megan E, Tasdemir, Nilgun, Bahreini, Amir, Chen, Jian, Levine, Kevin M, Priedigkeit, Nolan M, Nasrazadani, Azadeh, Ali, Simak, Buluwela, Laki, Arnesen, Spencer, Gertz, Jason, Richer, Jennifer K, Troness, Benjamin, El-Ashry, Dorraya, Zhang, Qiang, Gerratana, Lorenzo, Zhang, Youbin, Cristofanilli, Massimo, Montanez, Maritza A, Sundd, Prithu, Wallace, Callen T, Watkins, Simon C, Fumagalli, Caterina, Guerini-Rocco, Elena, Zhu, Li, Tseng, George C, Wagle, Nikhil, Carroll, Jason S, Jank, Paul, Denkert, Carsten, Karsten, Maria M, Blohmer, Jens-Uwe, Park, Ben H, Lucas, Peter C, Atkinson, Jennifer M, Lee, Adrian V, Oesterreich, Steffi

“…Constitutively active estrogen receptor α (ER/ESR1) mutations have been identified in approximately one-third of ER+ metastatic breast cancers. Although these…”
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An Analysis of PIK3CA Hotspot Mutations and Response to Neoadjuvant Therapy in Patients with Breast Cancer from Four Prospective Clinical Trials by Jank, Paul, Karn, Thomas, van Mackelenbergh, Marion, Lindner, Judith, Treue, Denise, Huober, Jens, Engels, Knut, Solbach, Christine, Diebold, Kurt, Marmé, Frederik, Müller, Volkmar, Schneeweiss, Andreas, Sinn, Hans-Peter, Fehm, Tanja, Schem, Christian, Stickeler, Elmar, Fasching, Peter, Budczies, Jan, Felder, Bärbel, Nekljudova, Valentina, Holtschmidt, Johannes, Untch, Michael, Denkert, Carsten, Loibl, Sibylle

“…The PI3K signaling pathway is frequently dysregulated in breast cancer, and mutations in PIK3CA are relevant for therapy resistance in HER2-positive (HER2pos)…”
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Relationship of adaptive subtyping and tumour heterogeneity of treatment response to neoadjuvant therapy in hormone receptor–positive HER2-negative early breast cancer: PENELOPE-B by Denkert, Carsten, Rachakonda, Krishna, Filipits, Martin, Weber, Karsten, Marmé, Frederik, Untch, Michael, Witkiewicz, Agnieszka K, Im, Seock-Ah, DeMichele, Angela, Pehl, Anika, van 't Veer, Laura, Jank, Paul, Schem, Christian, Fasching, Peter A., Reimer, Toralf, Knudsen, Erik S., Liu, Yuan, Rojo Todo, Federico Gustavo, Turner, Nicholas C., Loibl, Sibylle

“…566 Background: The concept of intrinsic subtyping has been an important step for understanding of breast cancer (BC) as a heterogenous disease. However, these…”
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Homologous Recombination Deficiency as an Ovarian Cancer Biomarker in a Real-World Cohort: Validation of Decentralized Genomic Profiling by Denkert, Carsten, Romey, Marcel, Swedlund, Brad, Hattesohl, Akira, Teply-Szymanski, Julia, Kommoss, Stefan, Kaiser, Kristin, Staebler, Annette, du Bois, Andreas, Grass, Albert, Knappmeyer, Christiane, Heitz, Florian, Solimeno, Cara, Ebel, Thomas, Harter, Philipp, Marmé, Frederik, Jank, Paul, Gaiser, Timo, Neff, Chris, Wagner, Uwe, Timms, Kirsten M, Rodepeter, Fiona

“…The diagnostic evaluation of homologous recombination deficiency (HRD) is central to define targeted therapy strategies for patients with ovarian carcinoma. We…”
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Abstract PS4-21: Comparison of risk assessment in primary ER+, HER2- Breast Cancer in a real-world data set: Classical pathological parameters vs. 12-gene molecular assay (EndoPredict) by Jank, Paul, Denkert, Carsten, Lindner, Judith L, Lehmann, Annika, Pfitzner, Berit M, Blohmer, Jens-Uwe, Horst, David, Kronenwett, Ralf, Schmitt, Wolfgang D

“…Abstract Background: Risk assessment on molecular level is becoming more common in modern pathology to determine the recurrence risk for patients diagnosed…”
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Increasing the efficiency of hyperthermic intraperitoneal chemotherapy (HIPEC) by combination with a photosensitive drug in pediatric rhabdomyosarcoma in an animal model by Wagner, Benedikt R., Adamus, Anna L., Hempfling, Laura, Vahdad, Reza, Haap‐Hoff, Antje, Heinrich, Benedikt, Vázquez, Olalla, Jank, Paul, Denkert, Carsten, Seitz, Guido

“…Background Cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is an option in advanced peritoneal sarcomatosis…”
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