Search Results - "Paul B. McCray, Jr"

CFTR-rich ionocytes mediate chloride absorption across airway epithelia by Lei, Lei, Traore, Soumba, Romano Ibarra, Guillermo S, Karp, Philip H, Rehman, Tayyab, Meyerholz, David K, Zabner, Joseph, Stoltz, David A, Sinn, Patrick L, Welsh, Michael J, McCray, Jr, Paul B, Thornell, Ian M

“…The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete…”
Get full text

Adherens junction protein nectin-4 is the epithelial receptor for measles virus by Mühlebach, Michael D., Mateo, Mathieu, Sinn, Patrick L., Prüfer, Steffen, Uhlig, Katharina M., Leonard, Vincent H. J., Navaratnarajah, Chanakha K., Frenzke, Marie, Wong, Xiao X., Sawatsky, Bevan, Ramachandran, Shyam, McCray, Paul B., Cichutek, Klaus, von Messling, Veronika, Lopez, Marc, Cattaneo, Roberto

“…Nectin-4 is identified as a receptor for measles virus on epithelial cells, and measles virus might use nectin-4 for emergence in the airways. Measles virus…”
Get full text

Cytokine-mediated regulation of antimicrobial proteins by Kolls, Jay K, McCray, Paul B, Chan, Yvonne R

“…Antimicrobial proteins are an ancient mechanism of defence against pathogens at skin and mucosal surfaces. As discussed in this Progress article, new studies…”
Get full text

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus by Kondratowicz, Andrew S, Lennemann, Nicholas J, Sinn, Patrick L, Davey, Robert A, Hunt, Catherine L, Moller-Tank, Sven, Meyerholz, David K, Rennert, Paul, Mullins, Robert F, Brindley, Melinda, Sandersfeld, Lindsay M, Quinn, Kathrina, Weller, Melodie, McCray, Paul B. Jr, Chiorini, John, Maury, Wendy

“…The glycoproteins (GP) of enveloped viruses facilitate entry into the host cell by interacting with specific cellular receptors. Despite extensive study, a…”
Get full text

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs by Rogers, Christopher S, Stoltz, David A, Meyerholz, David K, Ostedgaard, Lynda S, Rokhlina, Tatiana, Taft, Peter J, Rogan, Mark P, Pezzulo, Alejandro A, Karp, Philip H, Itani, Omar A, Kabel, Amanda C, Wohlford-Lenane, Christine L, Davis, Greg J, Hanfland, Robert A, Smith, Tony L, Samuel, Melissa, Wax, David, Murphy, Clifton N, Rieke, August, Whitworth, Kristin, Uc, Aliye, Starner, Timothy D, Brogden, Kim A, Shilyansky, Joel, McCray, Paul B. Jr, Zabner, Joseph, Prather, Randall S, Welsh, Michael J

“…Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis (CF), we still lack answers to many questions about the pathogenesis…”
Get full text

Lentiviral vectors transduce lung stem cells without disrupting plasticity by Cooney, Ashley L., Thurman, Andrew L., McCray, Paul B., Pezzulo, Alejandro A., Sinn, Patrick L.

“…Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic…”
Get full text

Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2 by Wong, Lok-Yin Roy, Li, Kun, Sun, Jing, Zhuang, Zhen, Zhao, Jincun, McCray, Paul B., Perlman, Stanley

“…Common laboratory mice such as BALB/c and C57BL/6 mice are not permissive to SARS-CoV2 infection. Sensitization of laboratory mice with Adenovirus expressing…”
Get full text

Current prospects for RNA interference-based therapies by Davidson, Beverly L, McCray, Paul B

“…Key Points RNA interference (RNAi) is a powerful approach for reducing expression of endogenously expressed proteins for biological applications, or targeting…”
Get full text

Advances in gene therapy for cystic fibrosis lung disease by Yan, Ziying, McCray Jr, Paul B, Engelhardt, John F

“…Abstract Cystic fibrosis (CF) is a multiorgan recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)…”
Get full text

Rapid generation of a mouse model for Middle East respiratory syndrome by Zhao, Jincun, Li, Kun, Wohlford-Lenane, Christine, Agnihothram, Sudhakar S., Fett, Craig, Zhao, Jingxian, Gale, Michael J., Baric, Ralph S., Enjuanes, Luis, Gallagher, Tom, McCray, Paul B., Perlman, Stanley

“…In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health…”
Get full text

Lentivirus Vectors Pseudotyped with Filoviral Envelope Glycoproteins Transduce Airway Epithelia from the Apical Surface Independently of Folate Receptor Alpha by Sinn, Patrick L, Hickey, Melissa A, Staber, Patrick D, Dylla, Douglas E, Jeffers, Scott A, Davidson, Beverly L, Sanders, David A, McCray, Jr, Paul B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung by Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph

“…In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface…”
Get full text

Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice by Sun, Young Joo, Velez, Gabriel, Parsons, Dylan E, Li, Kun, Ortiz, Miguel E, Sharma, Shaunik, McCray, Jr, Paul B, Bassuk, Alexander G, Mahajan, Vinit B

“…Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease and limit morbidity, even with antivirals and vaccination…”
Get full text

JunD Protects the Liver from Ischemia/Reperfusion Injury by Dampening AP-1 Transcriptional Activation by Marden, Jennifer J., Zhang, Yulong, Oakley, Fredrick D., Zhou, Weihong, Luo, Meihui, Jia, Hong Peng, McCray, Paul B., Yaniv, Moshe, Weitzman, Jonathan B., Engelhardt, John F.

“…The AP-1 transcription factor modulates a wide range of cellular processes, including cellular proliferation, programmed cell death, and survival. JunD is a…”
Get full text

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract by Ortiz, Miguel E., Thurman, Andrew, Pezzulo, Alejandro A., Leidinger, Mariah R., Klesney-Tait, Julia A., Karp, Philip H., Tan, Ping, Wohlford-Lenane, Christine, McCray, Paul B., Meyerholz, David K.

“…Zoonotically transmitted coronaviruses are responsible for three disease outbreaks since 2002, including the current COVID-19 pandemic, caused by SARS-CoV-2…”
Get full text

High ionic strength vector formulations enhance gene transfer to airway epithelia by Cooney, Ashley L, Loza, Laura Marquez, Najdawi, Kenan, Brommel, Christian M, McCray, Paul B, Sinn, Patrick L

“…Abstract A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient transduction of airway epithelia to achieve therapeutic…”
Get full text

piggyBac transposase tools for genome engineering by Li, Xianghong, Burnight, Erin R, Cooney, Ashley L, Malani, Nirav, Brady, Troy, Sander, Jeffry D, Staber, Janice, Wheelan, Sarah J, Joung, J Keith, McCray, Jr, Paul B, Bushman, Frederic D, Sinn, Patrick L, Craig, Nancy L

“…The transposon piggyBac is being used increasingly for genetic studies. Here, we describe modified versions of piggyBac transposase that have potentially…”
Get full text

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes by Channappanavar, Rudragouda, Fehr, Anthony R, Zheng, Jian, Wohlford-Lenane, Christine, Abrahante, Juan E, Mack, Matthias, Sompallae, Ramakrishna, McCray, Jr, Paul B, Meyerholz, David K, Perlman, Stanley

“…Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is…”
Get full text

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia by Jia, Hong Peng, Look, Dwight C, Tan, Ping, Shi, Lei, Hickey, Melissa, Gakhar, Lokesh, Chappell, Mark C, Wohlford-Lenane, Christine, McCray, Jr, Paul B

“…Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses (CoV). Loss of ACE2 function is…”
Get more information

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia by Krishnamurthy, Sateesh, Behlke, Mark A, Ramachandran, Shyam, Salem, Aliasger K, McCray Jr, Paul B, Davidson, Beverly L

“…The application of RNA interference-based gene silencing to the airway surface epithelium holds great promise to manipulate host and pathogen gene expression…”
Get full text