Search Results - "Paul‐Clark, M"

Cigarette smoke inhibits macrophage sensing of Gram‐negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress by McMaster, S K, Paul‐Clark, M J, Walters, M, Fleet, M, Anandarajah, J, Sriskandan, S, Mitchell, J A

“…Background and purpose: Smoking cigarettes is a major risk factor for the development of cardiovascular and respiratory disease. Moreover, smokers are more…”
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Aspirin and the in vitro linear relationship between thromboxane A2‐mediated platelet aggregation and platelet production of thromboxane A2 by ARMSTRONG, P. C. J., TRUSS, N. J., ALI, F. Y., DHANJI, A. A., VOJNOVIC, I., ZAIN, Z. N. M., BISHOP‐BAILEY, D., PAUL‐CLARK, M. J., TUCKER, A. T., MITCHELL, J. A., WARNER, T. D.

“…Background: Currently, ‘aspirin resistance’, the anti‐platelet effects of non‐steroid anti‐inflammatory drugs (NSAIDs) and NSAID‐aspirin interactions are hot…”
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Pattern recognition receptors and interleukin‐8 mediate effects of Gram‐positive and Gram‐negative bacteria on lung epithelial cell function by Sorrentino, R, De Souza, P M, Sriskandan, S, Duffin, C, Paul‐Clark, M J, Mitchell, J A

“…Background and purpose: Lung epithelial cells express pattern recognition receptors, which react to bacteria. We have evaluated the effect of Gram‐positive and…”
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Role of pattern-recognition receptors in cardiovascular health and disease by Mitchell, J A, Ryffel, B, Quesniaux, V F J, Cartwright, N, Paul-Clark, M

“…A role for PRRs (pattern-recognition receptors) in immune cell function is now well established. In macrophages and other immune cells, activation of TLRs…”
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Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll‐like receptor 4 responses in macrophages by Moreno, L, McMaster, SK, Gatheral, T, Bailey, LK, Harrington, LS, Cartwright, N, Armstrong, PCJ, Warner, TD, Paul‐Clark, M, Mitchell, JA

“…Background and purpose:  Gram‐negative bacteria contain ligands for Toll‐like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors…”
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Neutrophil Interaction with Inflamed Postcapillary Venule Endothelium Alters Annexin 1 Expression by Oliani, Sonia M., Paul-Clark, Mark J., Christian, Helen C., Flower, Roderick J., Perretti, Mauro

“…Annexin 1 (ANX-A1) exerts antimigratory actions in several models of acute and chronic inflammation. This is related to its ability to mimic the effect of…”
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Operative and 5-year outcomes of combined carotid and coronary revascularization: review of a large contemporary experience by Zacharias, Anoar, Schwann, Thomas A, Riordan, Christopher J, Clark, Paul M, Martinez, Bernardo, Durham, Samuel J, Engoren, Milo, Habib, Robert H

“…Background. Surgical treatment of concomitant coronary and carotid disease is controversial. Studies comparing staged versus combined coronary artery bypass…”
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The annexin-1 knockout mouse: what it tells us about the inflammatory response by Roviezzo, F, Getting, S J, Paul-Clark, M J, Yona, S, Gavins, F N E, Perretti, M, Hannon, R, Croxtall, J D, Buckingham, J C, Flower, R J

“…The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell…”
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Nitric Oxide Synthase Inhibitors Have Opposite Effects on Acute Inflammation Depending on Their Route of Administration by Paul-Clark, Mark J, Gilroy, Derek W, Willis, Dean, Willoughby, Derek A, Tomlinson, Annette

“…The bulk of published data has shown that NO is proinflammatory. However, there also exists the conflicting notion that NO may be protective during an…”
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Pharmacology and therapeutic potential of pattern recognition receptors by Paul-Clark, M J, George, P M, Gatheral, T, Parzych, K, Wright, W R, Crawford, D, Bailey, L K, Reed, D M, Mitchell, J A

“…Pharmacologists have used pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) for decades as a stimulus for studying mediators…”
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Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids by Perretti, M, Paul-Clark, M.J, Mancini, L, Flower, R.J

“…Addition to the prednisolone structure of a chemical moiety (linker+nitric ester) that releases NO species yielded a novel glucocorticoid (nitro-prednisolone…”
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Claviculectomy With Thrombectomy for Management of Paget-Schroetter Syndrome in a Patient With Chronic Clavicular Malunion by Coughlin, Lisa M, Koenig, Kelly N, Clark, Paul M

“…Paget-Schroetter syndrome, or primary upper extremity deep vein thrombosis, is a relatively rare condition for which various treatment protocols have been…”
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Inducible cyclooxygenase may have anti-inflammatory properties by Gilroy, Derek W, Colville-Nash, P.R, Willis, D, Chivers, J, Paul-Clark, M.J, Willoughby, D.A

“…Cyclooxygenase (COX) has two isoforms. Generally, COX 1 is constitutively expressed in most tissues, where it maintains physiological processes; inducible COX…”
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Modulation of Heme Oxygenase Activity in Rat Brain and Spleen by Inhibitors and Donors of Nitric Oxide by Willis, D., Tomlinson, A., Frederick, R., Paulclark, M.J., Willoughby, D.A.

“…The capacity of nitric oxide to activate or inhibit metalloprotein-containing enzymes underlies many of its biological actions. Heme oxygenase, involved in a…”
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Reflections on quality assessment in England: 1993-1996 by Clark, Paul M

“…Reflects on the quality assessment experience from 1993 to 1996. Discusses the issues raised during that period, the historical situation of higher education…”
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The enhanced anti-inflammatory properties of nitro-prednisolone (NCX-1015) is linked to post-translational modification of the glucocorticoid receptor by Paul-Clark, M. J., Perretti, M.

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C53 CLINICAL EVALUATION AND BIOMARKERS OF PULMONARY HYPERTENSION II: Peripheral Blood Mononuclear Cells From Patients With Idiopathic Pulmonary Arterial Hypertension Are Hyporesponsive To Inflammatory Stimuli by Price, L C, Paul-Clark, M, Meng, C, Shao, D, Mumby, S, Mitchell, J, Adcock, I M, Wort, S J

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Inducible cyclooxygenase may have anti-inflammatory properties by Gilroy, Derek W., Colville-Nash, P.R., Willis, D., Chivers, J., Paul-Clark, M.J., Willoughby, D.A.

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21‐NO‐prednisolone is a novel nitric oxide‐releasing derivative of prednisolone with enhanced anti‐inflammatory properties by Paul‐Clark, Mark, Del Soldato, Piero, Fiorucci, Stefano, Flower, Roderick J, Perretti, Mauro

“…Anti‐inflammatory effects of a novel derivative of the glucocorticoid prednisolone were investigated. NCX‐1015 (prednisolone 21‐[(4′‐nitrooxymethyl)benzoate])…”
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Venous Thromboembolism Rates for Hospitalized Patients Injured in Iraq or Afghanistan and Treated With Neuraxial Blockade by Clark, Paul, MD, Holley, Aaron, MD

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