Search Results - "Paul, Potter"

Astrocytes at the intersection of ageing, obesity, and neurodegeneration by Firth, Wyn, Pye, Katherine R, Weightman Potter, Paul G

“…Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence…”
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Global Miocene tectonics and the modern world by Potter, Paul Edwin, Szatmari, Peter

“…An amazing congruence of seemingly unrelated, diverse global events began in the Middle and Upper Miocene and established our modern world. Two global orogenic…”
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Immunometabolic Changes in Glia – A Potential Role in the Pathophysiology of Obesity and Diabetes by Robb, Josephine L., Morrissey, Nicole A., Weightman Potter, Paul G., Smithers, Hannah E., Beall, Craig, Ellacott, Kate L.J.

“…[Display omitted] •Glia direct respond to changes in nutrients and hormones regulating energy balance.•Microglia and astrocytes are implicated in the…”
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Randomized placebo-controlled trial of the bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial by Lumry, William R., MD, Li, H. Henry, MD, PhD, Levy, Robyn J., MD, Potter, Paul C., FCP(SA), MD (Cape Town), Farkas, Henriette, MD, PhD, DSc, Moldovan, Dumitru, MD, PhD, Riedl, Marc, MD, Li, Hongbin, MS, Craig, Timothy, DO, Bloom, Bradley J., MD, Reshef, Avner, MD

“…Background The For Angioedema Subcutaneous Treatment (FAST)-3 study was a phase III, randomized, double-blind, placebo-controlled study of icatibant…”
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Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes by Weightman Potter, Paul G., Vlachaki Walker, Julia M., Robb, Josephine L., Chilton, John K., Williamson, Ritchie, Randall, Andrew D, Ellacott, Kate L. J., Beall, Craig

“…Aims/hypothesis Hypoglycaemia is a major barrier to good glucose control in type 1 diabetes. Frequent hypoglycaemic episodes impair awareness of subsequent…”
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Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT by Nicol, Thomas, Falcone, Sara, Blease, Andrew, Vikhe, Pratik, Civiletto, Gabriele, Omairi, Saleh Salman, Viscomi, Carlo, Patel, Ketan, Potter, Paul K

“…Abstract Aims Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones…”
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Does age matter? The impact of rodent age on study outcomes by Jackson, Samuel J, Andrews, Nick, Ball, Doug, Bellantuono, Ilaria, Gray, James, Hachoumi, Lamia, Holmes, Alan, Latcham, Judy, Petrie, Anja, Potter, Paul, Rice, Andrew, Ritchie, Alison, Stewart, Michelle, Strepka, Carol, Yeoman, Mark, Chapman, Kathryn

“…Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is…”
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The metabolic response to inflammation in astrocytes is regulated by nuclear factor‐kappa B signaling by Robb, Josephine L., Hammad, Nadia A., Weightman Potter, Paul G., Chilton, John K., Beall, Craig, Ellacott, Kate L. J.

“…Inflammation and metabolism are intrinsically linked with inflammatory stimuli inducing metabolic changes in cells and, in turn, metabolic capacity determining…”
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Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language by Passalacqua, Giovanni, MD, Baena-Cagnani, Carlos E., MD, Bousquet, Jean, MD, Canonica, Giorgio Walter, MD, Casale, Thomas B., MD, Cox, Linda, MD, Durham, Stephen R., MD, Larenas-Linnemann, Desiréé, MD, Ledford, Dennis, MD, Pawankar, Ruby, MD, Potter, Paul, MD, Rosario, Nelson, MD, Wallace, Dana, MD, Lockey, Richard F., MD

“…Sublingual immunotherapy (SLIT) is increasingly used worldwide. Despite its safety being well ascertained, there is no universally accepted system to grade and…”
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The Mammalian Genome special issue on ageing by Potter, Paul K.

“…Issue Title: Special Issue: Aging…”
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A novel model of nephrotic syndrome results from a point mutation in Lama5 and is modified by genetic background by Falcone, Sara, Nicol, Thomas, Blease, Andrew, Randles, Michael J, Angus, Elizabeth, Page, Anton, Tam, Frederick W K, Pusey, Charles D, Lennon, Rachel, Potter, Paul K

“…Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the…”
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Chronically elevated branched chain amino acid levels are pro-arrhythmic by Portero, Vincent, Nicol, Thomas, Podliesna, Svitlana, Marchal, Gerard A, Baartscheer, Antonius, Casini, Simona, Tadros, Rafik, Treur, Jorien L, Tanck, Michael W T, Cox, I Jane, Probert, Fay, Hough, Tertius A, Falcone, Sara, Beekman, Leander, Müller-Nurasyid, Martina, Kastenmüller, Gabi, Gieger, Christian, Peters, Annette, Kääb, Stefan, Sinner, Moritz F, Blease, Andrew, Verkerk, Arie O, Bezzina, Connie R, Potter, Paul K, Remme, Carol Ann

“…Abstract Aims Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac…”
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Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing by Nicod, Jérôme, Davies, Robert W, Cai, Na, Hassett, Carl, Goodstadt, Leo, Cosgrove, Cormac, Yee, Benjamin K, Lionikaite, Vikte, McIntyre, Rebecca E, Remme, Carol Ann, Lodder, Elisabeth M, Gregory, Jennifer S, Hough, Tertius, Joynson, Russell, Phelps, Hayley, Nell, Barbara, Rowe, Clare, Wood, Joe, Walling, Alison, Bopp, Nasrin, Bhomra, Amarjit, Hernandez-Pliego, Polinka, Callebert, Jacques, Aspden, Richard M, Talbot, Nick P, Robbins, Peter A, Harrison, Mark, Fray, Martin, Launay, Jean-Marie, Pinto, Yigal M, Blizard, David A, Bezzina, Connie R, Adams, David J, Franken, Paul, Weaver, Tom, Wells, Sara, Brown, Steve D M, Potter, Paul K, Klenerman, Paul, Lionikas, Arimantas, Mott, Richard, Flint, Jonathan

“…Jonathan Flint, Richard Mott and colleagues employ low-coverage (0.15×) sequencing and their new imputation method STITCH to perform genome-wide association…”
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Clinical and cytokine responses to house dust mite sublingual immunotherapy by Potter, Paul C., MD, MBChB, DCH, FCP, Baker, Sheila, MSc, Fenemore, Bartha, Dip Med Tech, Nurse, Barbara, PhD

“…Abstract Background Cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not previously been reported. Objective To…”
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AMP‐activated protein kinase (AMPK) activator A‐769662 increases intracellular calcium and ATP release from astrocytes in an AMPK‐independent manner by Vlachaki Walker, Julia M., Robb, Josephine L., Cruz, Ana M., Malhi, Amrinder, Weightman Potter, Paul G., Ashford, Michael L. J., McCrimmon, Rory J., Ellacott, Kate L. J., Beall, Craig

“…Aim To test the hypothesis that, given the role of AMP‐activated protein kinase (AMPK) in regulating intracellular ATP levels, AMPK may alter ATP release from…”
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Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep by Banks, Gareth, Heise, Ines, Starbuck, Becky, Osborne, Tamzin, Wisby, Laura, Potter, Paul, Jackson, Ian J, Foster, Russell G, Peirson, Stuart N, Nolan, Patrick M

“…Abstract The circadian system is entrained to the environmental light/dark cycle via retinal photoreceptors and regulates numerous aspects of physiology and…”
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Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations by Maddirevula, Sateesh, Shagrani, Mohammad, Ji, Ae-Ri, Horne, Christopher R., Young, Samuel N., Mather, Lucy J., Alqahtani, Mashael, McKerlie, Colin, Wood, Geoffrey, Potter, Paul K., Abdulwahab, Firdous, AlSheddi, Tarfa, van der Woerd, Wendy L., van Gassen, Koen L.I., AlBogami, Dalal, Kumar, Kishwer, Muhammad Akhtar, Ali Syed, Binomar, Hiba, Almanea, Hadeel, Faqeih, Eissa, Fuchs, Sabine A., Scott, John W., Murphy, James M., Alkuraya, Fowzan S.

“…Pediatric cholestasis is the phenotypic expression of clinically and genetically heterogeneous disorders of bile acid synthesis and flow. Although a growing…”
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Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes by Weightman Potter, Paul G, Ellacott, Kate L J, Randall, Andrew D, Beall, Craig

“…Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced…”
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Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium by Christopher, Joseph, Thorsen, Ann-Sofie, Abujudeh, Sam, Lourenço, Filipe C, Kemp, Richard, Potter, Paul K, Morrissey, Edward, Hazelwood, Lee, Winton, Douglas J

“…Microsatellite sequences have an enhanced susceptibility to mutation, and can act as sentinels indicating elevated mutation rates and increased risk of cancer…”
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Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background by Falcone, Sara, Wisby, Laura, Nicol, Thomas, Blease, Andrew, Starbuck, Becky, Parker, Andrew, Sanderson, Jeremy, Brown, Steve D. M., Scudamore, Cheryl L., Pusey, Charles D., Tam, Frederick W. K., Potter, Paul K.

“…The link between mutations in collagen genes and the development of Alport Syndrome has been clearly established and a number of animal models, including…”
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