Search Results - "Paul, Nikki R"

Endocytic Trafficking of Integrins in Cell Migration by Paul, Nikki R., Jacquemet, Guillaume, Caswell, Patrick T.

“…Integrins are a family of heterodimeric receptors that bind to components of the extracellular matrix and influence cellular processes as varied as…”
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The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis by Papalazarou, Vassilis, Zhang, Tong, Paul, Nikki R., Juin, Amelie, Cantini, Marco, Maddocks, Oliver D. K., Salmeron-Sanchez, Manuel, Machesky, Laura M.

“…Pancreatic ductal adenocarcinoma is particularly metastatic, with dismal survival rates and few treatment options. Stiff fibrotic stroma is a hallmark of…”
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α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 by Paul, Nikki R, Allen, Jennifer L, Chapman, Anna, Morlan-Mairal, Maria, Zindy, Egor, Jacquemet, Guillaume, Fernandez del Ama, Laura, Ferizovic, Nermina, Green, David M, Howe, Jonathan D, Ehler, Elisabeth, Hurlstone, Adam, Caswell, Patrick T

“…Invasive migration in 3D extracellular matrix (ECM) is crucial to cancer metastasis, yet little is known of the molecular mechanisms that drive reorganization…”
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NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4 by Whyte, Declan, Skalka, George, Walsh, Peter, Wilczynska, Ania, Paul, Nikki R., Mitchell, Claire, Nixon, Colin, Clarke, William, Bushell, Martin, Morton, Jennifer P., Murphy, Daniel J., Muthalagu, Nathiya

“…The AMP‐activated protein kinase (AMPK)‐related kinase NUAK1 (NUAK family SNF1‐like kinase 1) has emerged as a potential vulnerability in MYC‐dependent cancer…”
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Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration by Thomas, Joanna R, Paul, Nikki R, Morgan, Mark R

“…Cell migration requires cells to sense and interpret an array of extracellular signals to precisely co-ordinate adhesion dynamics, local application of…”
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A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation by Burgess, Selena G, Paul, Nikki R, Richards, Mark W, Ault, James R, Askenatzis, Laurie, Claydon, Sophie G, Corbyn, Ryan, Machesky, Laura M, Bayliss, Richard

“…Fascin-1-mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulated formation of…”
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An evaluation of multi-excitation-wavelength standing-wave fluorescence microscopy (TartanSW) to improve sampling density in studies of the cell membrane and cytoskeleton by Schniete, Jana K., Tinning, Peter W., Scrimgeour, Ross C., Robb, Gillian, Kölln, Lisa S., Wesencraft, Katrina, Paul, Nikki R., Bushell, Trevor J., McConnell, Gail

“…Conventional standing-wave (SW) fluorescence microscopy uses a single wavelength to excite fluorescence from the specimen, which is normally placed in contact…”
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A Reliable System for Quantitative G-Protein Activation Imaging in Cancer Cells by Mandrou, Elena, Thomason, Peter A, Paschke, Peggy I, Paul, Nikki R, Tweedy, Luke, Insall, Robert H

“…Fluorescence resonance energy transfer (FRET) biosensors have proven to be an indispensable tool in cell biology and, more specifically, in the study of…”
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CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors by Whitelaw, Jamie A., Lilla, Sergio, Paul, Nikki R., Fort, Loic, Zanivan, Sara, Machesky, Laura M.

“…Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid…”
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CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation by Le, Anh Hoang, Yelland, Tamas, Paul, Nikki R, Fort, Loic, Nikolaou, Savvas, Ismail, Shehab, Machesky, Laura M

“…The Scar/WAVE complex drives actin nucleation during cell migration. Interestingly, the same complex is important in forming membrane ruffles during…”
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Emerging properties of adhesion complexes: what are they and what do they do? by Humphries, Jonathan D, Paul, Nikki R, Humphries, Martin J, Morgan, Mark R

“…Highlights • Proteomics and advanced imaging provide complementary insights into adhesion biology. • A ‘core’ complex of adhesion components linking to the…”
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Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function by Santi, Alice, Kay, Emily J, Neilson, Lisa J, McGarry, Lynn, Lilla, Sergio, Mullin, Margaret, Paul, Nikki R, Fercoq, Frédéric, Koulouras, Grigorios, Rodriguez Blanco, Giovanny, Athineos, Dimitris, Mason, Susan, Hughes, Mark, Thomson, Gemma, Kieffer, Yann, Nixon, Colin, Blyth, Karen, Mechta-Grigoriou, Fatima, Carlin, Leo M, Zanivan, Sara

“…Intercellular communication between different cell types in solid tumors contributes to tumor growth and metastatic dissemination. The secretome of…”
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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents by Francis, Stuart, Croft, Daniel, Schüttelkopf, Alexander W., Parry, Charles, Pugliese, Angelo, Cameron, Ken, Claydon, Sophie, Drysdale, Martin, Gardner, Claire, Gohlke, Andrea, Goodwin, Gillian, Gray, Christopher H., Konczal, Jennifer, McDonald, Laura, Mezna, Mokdad, Pannifer, Andrew, Paul, Nikki R., Machesky, Laura, McKinnon, Heather, Bower, Justin

“…[Display omitted] Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive…”
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Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics by Koessinger, Anna L., Cloix, Catherine, Koessinger, Dominik, Heiland, Dieter Henrik, Bock, Florian J., Strathdee, Karen, Kinch, Kevin, Martínez-Escardó, Laura, Paul, Nikki R., Nixon, Colin, Malviya, Gaurav, Jackson, Mark R., Campbell, Kirsteen J., Stevenson, Katrina, Davis, Sandeep, Elmasry, Yassmin, Ahmed, Asma, O’Prey, Jim, Ichim, Gabriel, Schnell, Oliver, Stewart, William, Blyth, Karen, Ryan, Kevin M., Chalmers, Anthony J., Norman, Jim C., Tait, Stephen W. G.

“…Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective…”
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Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly by Horton, Edward R., Byron, Adam, Askari, Janet A., Ng, Daniel H. J., Millon-Frémillon, Angélique, Robertson, Joseph, Koper, Ewa J., Paul, Nikki R., Warwood, Stacey, Knight, David, Humphries, Jonathan D., Humphries, Martin J.

“…Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at the cell membrane that transduce adhesion-dependent signals to…”
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CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake by Nikolaou, Savvas, Juin, Amelie, Whitelaw, Jamie A, Paul, Nikki R, Fort, Loic, Nixon, Colin, Spence, Heather J, Bryson, Sheila, Machesky, Laura M

“…Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all…”
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Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin by Woodham, Emma F., Paul, Nikki R., Tyrrell, Benjamin, Spence, Heather J., Swaminathan, Karthic, Scribner, Michelle R., Giampazolias, Evangelos, Hedley, Ann, Clark, William, Kage, Frieda, Marston, Daniel J., Hahn, Klaus M., Tait, Stephen W.G., Larue, Lionel, Brakebusch, Cord H., Insall, Robert H., Machesky, Laura M.

“…The individual molecular pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingly little about how these pathways are…”
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Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics by Robertson, Joseph, Humphries, Jonathan D, Paul, Nikki R, Warwood, Stacey, Knight, David, Byron, Adam, Humphries, Martin J

“…Integrin adhesion receptors engage with their extracellular matrix (ECM) ligands, initiating intracellular signaling pathways that regulate a range of…”
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Isolation of integrin-based adhesion complexes by Jones, Matthew C, Humphries, Jonathan D, Byron, Adam, Millon-Frémillon, Angélique, Robertson, Joseph, Paul, Nikki R, Ng, Daniel H J, Askari, Janet A, Humphries, Martin J

“…The integration of cells with their extracellular environment is facilitated by cell surface adhesion receptors, such as integrins, which play important roles…”
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a5[Beta]1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 by Paul, Nikki R, Allen, Jennifer L, Chapman, Anna, Morlan-Mairal, Maria, Zindy, Egor, Jacquemet, Guillaume, del Ama, Laura Fernandez, Ferizovic, Nermina, Green, David M, Howe, Jonathan D, Ehler, Elisabeth, Hurlstone, Adam, Caswell, Patrick T

“…Invasive migration in 3D extracellular matrix (ECM) is crucial to cancer metastasis, yet little is known of the molecular mechanisms that drive reorganization…”
Get full text