Search Results - "Paul, Mariel C."

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer by Schönhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B, Paul, Mariel C, Eser, Philipp, Klein, Sabine, Lowy, Andrew M, Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J, Kirsch, David G, Scheideler, Angelika, Alessi, Dario R, Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E, Rodewald, Hans-Reimer, Rad, Roland, Schmid, Roland M, Schneider, Günter, Saur, Dieter

“…The next generation of genetically engineered mouse models of pancreatic cancer involving a new inducible dual-recombinase system that combines Flp- FRT and…”
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EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer by Martini, Giulia, Cardone, Claudia, Vitiello, Pietro Paolo, Belli, Valentina, Napolitano, Stefania, Troiani, Teresa, Ciardiello, Davide, Della Corte, Carminia Maria, Morgillo, Floriana, Matrone, Nunzia, Sforza, Vincenzo, Papaccio, Gianpaolo, Desiderio, Vincenzo, Paul, Mariel C, Moreno-Viedma, Veronica, Normanno, Nicola, Rachiglio, Anna Maria, Tirino, Virginia, Maiello, Evaristo, Latiano, Tiziana Pia, Rizzi, Daniele, Signoriello, Giuseppe, Sibilia, Maria, Ciardiello, Fortunato, Martinelli, Erika

“…The EPHA2 tyrosine kinase receptor is implicated in tumor progression and targeted therapies resistance. We evaluated EPHA2 as a potential resistance marker to…”
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E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex by von Burstin, Johannes, Eser, Stefan, Paul, Mariel C, Seidler, Barbara, Brandl, Martina, Messer, Marlena, von Werder, Alexander, Schmidt, Annegret, Mages, Jörg, Pagel, Philipp, Schnieke, Angelika, Schmid, Roland M, Schneider, Günter, Saur, Dieter

“…Background & Aims Early metastasis is a hallmark of pancreatic ductal adenocarcinoma and responsible for >90% of pancreatic cancer death. Because little is…”
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Non-canonical functions of SNAIL drive context-specific cancer progression by Paul, Mariel C., Schneeweis, Christian, Falcomatà, Chiara, Shan, Chuan, Rossmeisl, Daniel, Koutsouli, Stella, Klement, Christine, Zukowska, Magdalena, Widholz, Sebastian A., Jesinghaus, Moritz, Heuermann, Konstanze K., Engleitner, Thomas, Seidler, Barbara, Sleiman, Katia, Steiger, Katja, Tschurtschenthaler, Markus, Walter, Benjamin, Weidemann, Sören A., Pietsch, Regina, Schnieke, Angelika, Schmid, Roland M., Robles, Maria S., Andrieux, Geoffroy, Boerries, Melanie, Rad, Roland, Schneider, Günter, Saur, Dieter

“…SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a…”
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EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients by Srivatsa, Sriram, Paul, Mariel C, Cardone, Claudia, Holcmann, Martin, Amberg, Nicole, Pathria, Paulina, Diamanti, Michaela A, Linder, Markus, Timelthaler, Gerald, Dienes, Hans P, Kenner, Lukas, Wrba, Fritz, Prager, Gerald W, Rose-John, Stefan, Eferl, Robert, Liguori, Giuseppina, Botti, Gerardo, Martinelli, Erika, Greten, Florian R, Ciardiello, Fortunato, Sibilia, Maria

“…Background & Aims Inhibitors of the epidermal growth factor receptor (EGFR) are the first-line therapy for patients with metastatic colorectal tumors without…”
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MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib by Wirth, Matthias, Stojanovic, Natasa, Christian, Jan, Paul, Mariel C, Stauber, Roland H, Schmid, Roland M, Häcker, Georg, Krämer, Oliver H, Saur, Dieter, Schneider, Günter

“…The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC…”
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Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models by Diersch, Sandra, Wenzel, Patrick, Szameitat, Melanie, Eser, Philipp, Paul, Mariel C, Seidler, Barbara, Eser, Stefan, Messer, Marlena, Reichert, Maximilian, Pagel, Philipp, Esposito, Irene, Schmid, Roland M, Saur, Dieter, Schneider, Günter

“…Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease with a poor prognosis and targeted therapies have failed in the clinic so far. Several…”
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Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination by Serth, Katrin, Beckers, Anja, Schuster-Gossler, Karin, Pavlova, Maria N, Müller, Julia, Paul, Mariel C, Reinhardt, Richard, Gossler, Achim

“…Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene…”
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Efemp1 and p27Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models by Diersch, Sandra, Wenzel, Patrick, Szameitat, Melanie, Eser, Philipp, Paul, Mariel C., Seidler, Barbara, Eser, Stefan, Messer, Marlena, Reichert, Maximilian, Pagel, Philipp, Esposito, Irene, Schmid, Roland M., Saur, Dieter, Schneider, Günter

“…Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease with a poor prognosis and targeted therapies have failed in the clinic so far. Several…”
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