Search Results - "Paul, Manash K"

Lung cancer immunotherapy: progress, pitfalls, and promises by Lahiri, Aritraa, Maji, Avik, Potdar, Pravin D, Singh, Navneet, Parikh, Purvish, Bisht, Bharti, Mukherjee, Anubhab, Paul, Manash K

“…Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery,…”
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Advances in the Fabrication of Scaffold and 3D Printing of Biomimetic Bone Graft by Bisht, Bharti, Hope, Ashley, Mukherjee, Anubhab, Paul, Manash K.

“…The need for bone grafts is tremendous, and that leads to the use of autograft, allograft, and bone graft substitutes. The biology of the bone is quite complex…”
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Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer by Mukherjee, Anubhab, Madamsetty, Vijay Sagar, Paul, Manash K, Mukherjee, Sudip

“…Angiogenesis is a process of generation of de-novo blood vessels from already existing vasculature. It has a crucial role in different physiological process…”
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CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening by Chhibber, Tanya, Bagchi, Sounak, Lahooti, Behnaz, Verma, Angela, Al-Ahmad, Abraham, Paul, Manash K., Pendyala, Gurudutt, Jayant, Rahul Dev

“…•3D CNS organoids share architecture and functions resembling the human brain.•Recapitulating key features of the early-stage brain under a controlled…”
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Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling by Paul, Manash K., Bisht, Bharti, Darmawan, Daphne O., Chiou, Richard, Ha, Vi L., Wallace, William D., Chon, Andrew T., Hegab, Ahmed E., Grogan, Tristan, Elashoff, David A., Alva-Ornelas, Jackelyn A., Gomperts, Brigitte N.

“…Airways are exposed to myriad environmental and damaging agents such as reactive oxygen species (ROS), which also have physiological roles as signaling…”
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Editorial: Pharmaceutically targeting hypoxia in the breast cancer microenvironment: mechanistic and translational approaches by Singh, Manjari, Paul, Manash K., Roy, Subhadeep

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Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics by Kumavath, Ranjith, Paul, Sayan, Pavithran, Honey, Paul, Manash K, Ghosh, Preetam, Barh, Debmalya, Azevedo, Vasco

“…Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well…”
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Development of a Three‐Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling by Wilkinson, Dan C., Alva‐Ornelas, Jackelyn A., Sucre, Jennifer M.S., Vijayaraj, Preethi, Durra, Abdo, Richardson, Wade, Jonas, Steven J., Paul, Manash K., Karumbayaram, Saravanan, Dunn, Bruce, Gomperts, Brigitte N.

“…Stem cell technologies, especially patient‐specific, induced stem cell pluripotency and directed differentiation, hold great promise for changing the landscape…”
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity by Purbey, Prabhat K., Seo, Joowon, Paul, Manash K., Iwamoto, Keisuke S., Daly, Allison E., Feng, An-Chieh, Champhekar, Ameya S., Langerman, Justin, Campbell, Katie M., Schaue, Dörthe, McBride, William H., Dubinett, Steven M., Ribas, Antoni, Smale, Stephen T., Scumpia, Philip O.

“…Type I interferon (IFN-I) and IFN-γ foster antitumor immunity by facilitating T cell responses. Paradoxically, IFNs may promote T cell exhaustion by activating…”
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Editorial: Role of extracellular vesicles (EVs) in pathogenesis, diagnosis, therapeutic delivery, treatment and theranostic applications in cancer by Shahbazi, Reza, Kalishwaralal, Kalimuthu, Paul, Manash K., Anto, Ruby John

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High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis by Aros, Cody J., Paul, Manash K., Pantoja, Carla J., Bisht, Bharti, Meneses, Luisa K., Vijayaraj, Preethi, Sandlin, Jenna M., France, Bryan, Tse, Jonathan A., Chen, Michelle W., Shia, David W., Rickabaugh, Tammy M., Damoiseaux, Robert, Gomperts, Brigitte N.

“…Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin…”
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Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule by Vijayaraj, Preethi, Minasyan, Aspram, Durra, Abdo, Karumbayaram, Saravanan, Mehrabi, Mehrsa, Aros, Cody J., Ahadome, Sarah D., Shia, David W., Chung, Katherine, Sandlin, Jenna M., Darmawan, Kelly F., Bhatt, Kush V., Manze, Chase C., Paul, Manash K., Wilkinson, Dan C., Yan, Weihong, Clark, Amander T., Rickabaugh, Tammy M., Wallace, W. Dean, Graeber, Thomas G., Damoiseaux, Robert, Gomperts, Brigitte N.

“…Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are…”
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Prognostic Indicators for Precision Treatment of Non-Small Cell Lung Carcinoma by Ghosh, Damayanti Das, McDonald, Hannah, Dutta, Rajeswari, Krishnan, Keerthana, Thilakan, Jaya, Paul, Manash K, Arya, Neha, Rao, Mahadev, Rangnekar, Vivek M

“…Non-small cell lung cancer (NSCLC) has established predictive biomarkers that enable decisions on treatment regimens for many patients. However, resistance to…”
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Statistical parametrization of cell cytoskeleton reveals lung cancer cytoskeletal phenotype with partial EMT signature by Basu, Arkaprabha, Paul, Manash K., Alioscha-Perez, Mitchel, Grosberg, Anna, Sahli, Hichem, Dubinett, Steven M., Weiss, Shimon

“…Epithelial–mesenchymal Transition (EMT) is a multi-step process that involves cytoskeletal rearrangement. Here, developing and using an image quantification…”
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Advances in targeting the WNT/β-catenin signaling pathway in cancer by Chatterjee, Avradip, Paul, Sayan, Bisht, Bharti, Bhattacharya, Shelley, Sivasubramaniam, Sudhakar, Paul, Manash K.

“…•Targeting the WNT/β-catenin signaling pathway.•Novel approaches towards targeting the WNT/β-catenin pathway.•WNT/β-catenin Pathway Inhibitors in Clinical…”
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Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy by Mukherjee, Anubhab, Bisht, Bharti, Dutta, Suman, Paul, Manash K.

“…Three major approaches of cancer therapy can be enunciated as delivery of biotherapeutics, tumor image analysis, and immunotherapy. Liposomes, artificial fat…”
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Emerging role and promise of nanomaterials in organoid research by Mahapatra, Chinmaya, Lee, Ruda, Paul, Manash K.

“…•Application of nanomaterials in organoid systems.•Nanoparticle interaction with organoids from different tissue sources.•Engineering organoid…”
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Organoid-based 3D in vitro microphysiological systems as alternatives to animal experimentation for preclinical and clinical research by Mukhopadhyay, Chrianjay, Paul, Manash K.

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Mechanistic insight into the protective and pathogenic immune-responses against SARS-CoV-2 by Purbey, Prabhat K., Roy, Koushik, Gupta, Sandeep, Paul, Manash K.

“…COVID-19 is a severe respiratory illness that has emerged as a devasting health problem worldwide. The disease outcome is heterogeneous, which is most likely…”
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A hybrid model integrating warm heat and ultraviolet germicidal irradiation might efficiently disinfect respirators and personal protective equipment by Banerjee, Rajib, Roy, Pulakesh, Das, Surajeet, Paul, Manash K.

“…•Coronavirus disease 2019 (COVID-19) has taken a heavy toll on human life.•Creating a hybrid model that efficiently sanitizes the mask and increases its…”
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