Search Results - "Paul, Harry"
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3D bioengineered tissue model of the large intestine to study inflammatory bowel disease
Published in Biomaterials (01-12-2019)“…An in vitro model of intestinal epithelium with an immune component was bioengineered to mimic immunologic responses seen in inflammatory bowel disease. While…”
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The Evolution of Gene Expression Plasticity During Adaptation to Salt in Chlamydomonas reinhardtii
Published in Genome biology and evolution (01-11-2024)“…Abstract When environmental change is rapid or unpredictable, phenotypic plasticity can facilitate adaptation to new or stressful environments to promote…”
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Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection
Published in Immunity (Cambridge, Mass.) (09-01-2024)“…Individuals who clear primary hepatitis C virus (HCV) infections clear subsequent reinfections more than 80% of the time, but the mechanisms are poorly…”
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Convergent antibody responses are associated with broad neutralization of hepatitis C virus
Published in Frontiers in immunology (24-03-2023)“…Early development of broadly neutralizing antibodies (bNAbs) targeting the hepatitis C virus (HCV) envelope glycoprotein E2 is associated with spontaneous…”
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Corrigendum: Convergent antibody responses are associated with broad neutralization of hepatitis C virus
Published in Frontiers in immunology (25-04-2023)“…[This corrects the article DOI: 10.3389/fimmu.2023.1135841.]…”
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Remarks on physics
Published in Physica scripta (01-04-2023)“…I compare and contrast classical and quantum descriptions and then argue that even the celebrated stability of matter following from the Schrödinger equation…”
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Who Kidnapped Excellence?: What Stops Us from Giving and Being Our Best
Published 2014“…Who Kidnapped Excellence?Most companies talk about excellence, but what does excellence really mean? What specific attitudes and practices lead to excellence?…”
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Who kidnapped excellence?
Published 2014“…Most companies talk about excellence, but what does excellence really mean? What specific attitudes and practices lead to excellence? Drawing on years of study…”
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Treatment discontinuation due to toxicity for patients with acute myeloid leukemia (AML) treated on SWOG S1203
Published in Journal of clinical oncology (01-06-2024)“…6529 Background: Curative-intent therapy for patients with newly diagnosed AML centers on the use of cytarabine as part of an intensive multi-drug induction…”
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P140 3D BIOENGINEERED TISSUE MODEL OF THE LARGE INTESTINE TO STUDY INFLAMMATORY BOWEL DISEASE
Published in Gastroenterology (New York, N.Y. 1943) (01-02-2020)Get full text
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P140 3D BIOENGINEERED TISSUE MODEL OF THE LARGE INTESTINE TO STUDY INFLAMMATORY BOWEL DISEASE
Published in Inflammatory bowel diseases (23-01-2020)“…Abstract An in vitro model of intestine epithelium with an immune compartment was bioengineered to mimic immunologic responses seen in inflammatory bowel…”
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Phase 1 study of ziftomenib (KO-539) in combination with venetoclax or venetoclax/azacitidine or standard induction cytarabine/daunorubicin (7+3) chemotherapy for the treatment of patients with acute myeloid leukemia
Published in Journal of clinical oncology (01-06-2023)“…TPS7079 Background: Relapsed or refractory (R/R) acute myeloid leukemia (AML) with nucleophosmin 1-mutations ( NPM1-m) or KMT2A-rearrangment ( KMT2A-r)…”
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Assessing eligibility for non-intensive chemotherapy (IC) randomized clinical trials (RCT) in patients (pts) with newly diagnosed (ND) AML from the Connect Myeloid Disease Registry
Published in Journal of clinical oncology (01-06-2022)“…7029 Background: Pts with AML in RCTs often do not reflect the population seen in clinical practice due to strict eligibility criteria. This study evaluated…”
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Preliminary results of V-FAST, a phase 1b master trial to investigate CPX-351 combined with targeted agents in newly diagnosed AML
Published in Journal of clinical oncology (20-05-2021)“…Abstract only 7026 Background: CPX-351 (US: Vyxeos; EU: Vyxeos Liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic…”
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V-FAST master trial: Preliminary results of treatment with CPX-351 plus midostaurin in adults with newly diagnosed FLT3 -mutated acute myeloid leukemia
Published in Journal of clinical oncology (01-06-2022)“…7043 Background: CPX-351 (US: Vyxeos; Europe: Vyxeos liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar…”
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Results of a phase 3 study of IVO vs IO for previously untreated older patients (pts) with chronic lymphocytic leukemia (CLL) and impact of COVID-19 (Alliance)
Published in Journal of clinical oncology (01-06-2023)“…7500 Background: The Bruton’s tyrosine kinase inhibitor (BTKi) ibrutinib +/- anti-CD20 antibody obinutuzumab (IO) is a standard frontline regimen for older…”
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Chemotherapy-free treatment with inotuzumab ozogamicin and blinatumomab for older adults with newly diagnosed, Ph-negative, CD22-positive, B-cell acute lymphoblastic leukemia: Alliance A041703
Published in Journal of clinical oncology (01-06-2023)“…7006 Background: Older adult patients (pts) with Philadelphia-chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) have poor survival with…”
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Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
Published in Nature immunology (01-03-2023)“…How lipidome changes support CD8 + effector T (T eff ) cell differentiation is not well understood. Here we show that, although naive T cells are rich in…”
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