Search Results - "Paul, Caroline E."

Biocatalytic Oxidation Reactions: A Chemist's Perspective by Dong, JiaJia, Fernández‐Fueyo, Elena, Hollmann, Frank, Paul, Caroline E., Pesic, Milja, Schmidt, Sandy, Wang, Yonghua, Younes, Sabry, Zhang, Wuyuan

“…Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox…”
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Efficient In Situ Regeneration of NADH Mimics by an Artificial Metalloenzyme by Okamoto, Yasunori, Köhler, Valentin, Paul, Caroline E, Hollmann, Frank, Ward, Thomas R

“…NADH mimics (mNADHs) have been shown to accelerate and orthogonally activate ene reductase-catalyzed reactions. However, existing regeneration methods of…”
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Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform by Zhang, Linyue, King, Edward, Black, William B., Heckmann, Christian M., Wolder, Allison, Cui, Youtian, Nicklen, Francis, Siegel, Justin B., Luo, Ray, Paul, Caroline E., Li, Han

“…Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P) + ) in biotransformation. However,…”
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Mimicking Nature: Synthetic Nicotinamide Cofactors for CC Bioreduction Using Enoate Reductases by Paul, Caroline E, Gargiulo, Serena, Opperman, Diederik J, Lavandera, Iván, Gotor-Fernández, Vicente, Gotor, Vicente, Taglieber, Andreas, Arends, Isabel W. C. E, Hollmann, Frank

“…A series of synthetic nicotinamide cofactors were synthesized to replace natural nicotinamide cofactors and promote enoate reductase (ER) catalyzed reactions…”
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Biocatalysis making waves in organic chemistry by Hanefeld, Ulf, Hollmann, Frank, Paul, Caroline E

“…Biocatalysis has an enormous impact on chemical synthesis. The waves in which biocatalysis has developed, and in doing so changed our perception of what…”
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Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines by Paul, Caroline E, Rodríguez-Mata, María, Busto, Eduardo, Lavandera, Iván, Gotor-Fernández, Vicente, Gotor, Vicente, García-Cerrada, Susana, Mendiola, Javier, de Frutos, Óscar, Collado, Iván

“…Critical parameters affecting the stereoselective amination of (hetero)­aromatic ketones using transaminases have been studied, such as temperature, pH,…”
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Biocatalytic Reduction Reactions from a Chemist's Perspective by Hollmann, Frank, Opperman, Diederik J., Paul, Caroline E.

“…Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite…”
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Applying Non-canonical Redox Cofactors in Fermentation Processes by Weusthuis, Ruud A., Folch, Pauline L., Pozo-Rodríguez, Ana, Paul, Caroline E.

“…Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield…”
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A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para-Phenol Oxidases by Ewing, Tom A, van Noord, Aster, Paul, Caroline E, van Berkel, Willem J H

“…Vanillyl alcohol oxidase (VAO) and eugenol oxidase (EUGO) are flavin-dependent enzymes that catalyse the oxidation of -substituted phenols. This makes them…”
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H2-driven biocatalysis for flavin-dependent ene-reduction in a continuous closed-loop flow system utilizing H2 from water electrolysis by Lim, Guiyeoul, Calabrese, Donato, Wolder, Allison, Cordero, Paul R. F., Rother, Dörte, Mulks, Florian F., Paul, Caroline E., Lauterbach, Lars

“…Despite the increasing demand for efficient and sustainable chemical processes, the development of scalable systems using biocatalysis for fine chemical…”
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Deep eutectic solvents for redox biocatalysis by Gotor-Fernández, Vicente, Paul, Caroline E.

“…•DES are emerging as an alternative media for redox biocatalysis.•DES are simple and cost-effective to produce and show good biocompatibility.•Potential impact…”
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Catalytic Performance of a Class III Old Yellow Enzyme and Its Cysteine Variants by Scholtissek, Anika, Gädke, Eric, Paul, Caroline E, Westphal, Adrie H, van Berkel, Willem J H, Tischler, Dirk

“…Class III old yellow enzymes (OYEs) contain a conserved cysteine in their active sites. To address the role of this cysteine in OYE-mediated asymmetric…”
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Stabilisation of the Fatty Acid Decarboxylase from Chlorella variabilis by Caprylic Acid by Wu, Yinqi, Paul, Caroline E., Hollmann, Frank

“…The fatty acid photodecarboxylase from Chlorella variabilis NC64 A (CvFAP) catalyses the light‐dependent decarboxylation of fatty acids. Photoinactivation of…”
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A survey of synthetic nicotinamide cofactors in enzymatic processes by Paul, Caroline E., Hollmann, Frank

“…Synthetic nicotinamide cofactors are analogues of the natural cofactors used by oxidoreductases as redox intermediates. Their ability to be fine-tuned makes…”
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Expanding the regioselective enzymatic repertoire: oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta by Paul, Caroline E, Rajagopalan, Aashrita, Lavandera, Iván, Gotor-Fernández, Vicente, Kroutil, Wolfgang, Gotor, Vicente

“…The first report of a biocatalytic regioselective oxidative mono-cleavage of dialkenes was successfully achieved employing a cell-free enzyme preparation from…”
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Functional characterization and stability improvement of a 'thermophilic-like' ene-reductase from Rhodococcus opacus 1CP by Riedel, Anika, Mehnert, Marika, Paul, Caroline E, Westphal, Adrie H, van Berkel, Willem J H, Tischler, Dirk

“…Ene-reductases (ERs) are widely applied for the asymmetric synthesis of relevant industrial chemicals. A novel ER OYERo2 was found within a set of 14 putative…”
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S -Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic by Kailing, Lyn L, Bertinetti, Daniela, Paul, Caroline E, Manszewski, Tomasz, Jaskolski, Mariusz, Herberg, Friedrich W, Pavlidis, Ioannis V

“…-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous…”
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Synthetic Biomimetic Coenzymes and Alcohol Dehydrogenases for Asymmetric Catalysis by Laia Josa-Culleré, Antti S. K. Lahdenperä, Aubert Ribaucourt, Georg T. Höfler, Serena Gargiulo, Yuan-Yang Liu, Jian-He Xu, Jennifer Cassidy, Francesca Paradisi, Diederik J. Opperman, Frank Hollmann, Caroline E. Paul

“…Redox reactions catalyzed by highly selective nicotinamide-dependent oxidoreductases are rising to prominence in industry. The cost of nicotinamide adenine…”
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Biocatalytic C=C Bond Reduction through Carbon Nanodot‐Sensitized Regeneration of NADH Analogues by Kim, Jinhyun, Lee, Sahng Ha, Tieves, Florian, Choi, Da Som, Hollmann, Frank, Paul, Caroline E., Park, Chan Beum

“…Light‐driven activation of redox enzymes is an emerging route for sustainable chemical synthesis. Among redox enzymes, the family of Old Yellow Enzyme (OYE)…”
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Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes by Knaus, Tanja, Paul, Caroline E, Levy, Colin W, de Vries, Simon, Mutti, Francesco G, Hollmann, Frank, Scrutton, Nigel S

“…The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Redox biotransformations are potentially attractive, but they…”
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