Search Results - "Paul, B."

Current prospects for RNA interference-based therapies by Davidson, Beverly L, McCray, Paul B

“…Key Points RNA interference (RNAi) is a powerful approach for reducing expression of endogenously expressed proteins for biological applications, or targeting…”
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Complement in the pathogenesis of Alzheimer’s disease by Morgan, B. Paul

“…The emergence of complement as an important player in normal brain development and pathological remodelling has come as a major surprise to most scientists…”
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COVID-19 fatalities, latitude, sunlight, and vitamin D by Whittemore, Paul B.

“…•A significant correlation was found between latitude and COVID-19 fatalities.•Countries closer to the equator have lower COVID-19 fatality rates than those…”
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Histone variants on the move: substrates for chromatin dynamics by Talbert, Paul B., Henikoff, Steven

“…Key Points Histone variants replace canonical histones to carry out diverse roles in replication, transcription and heterochromatin formation, all of which are…”
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The membrane attack complex as an inflammatory trigger by Morgan, B. Paul

“…Abstract The final common pathway of all routes of complement activation involves the non-enzymatic assembly of a complex comprising newly formed C5b with the…”
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Histone variants at a glance by Talbert, Paul B, Henikoff, Steven

“…Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and…”
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The innate immune function of airway epithelial cells in inflammatory lung disease by Hiemstra, Pieter S, McCray, Jr, Paul B, Bals, Robert

“…The airway epithelium is now considered to be central to the orchestration of pulmonary inflammatory and immune responses, and is also key to tissue…”
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High-Intensity Interval Training, Solutions to the Programming Puzzle: Part I: Cardiopulmonary Emphasis by Buchheit, Martin, Laursen, Paul B.

“…High-intensity interval training (HIT), in a variety of forms, is today one of the most effective means of improving cardiorespiratory and metabolic function…”
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Targeting repetitive transcranial magnetic stimulation in depression: do we really know what we are stimulating and how best to do it? by Fitzgerald, Paul B.

“…Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for patients with depression who have not achieved optimal outcomes with one or…”
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An update on the clinical use of repetitive transcranial magnetic stimulation in the treatment of depression by Fitzgerald, Paul B.

“…•rTMS is an effective treatment for depression that is mostly well tolerated and safe.•There are multiple forms of rTMS with established efficacy but no form…”
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The humanitarian system is not just broke, but broken: recommendations for future humanitarian action by Spiegel, Paul B, Prof

“…Summary An unprecedented number of humanitarian emergencies of large magnitude and duration is causing the largest number of people in a generation to be…”
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Complement, a target for therapy in inflammatory and degenerative diseases by Morgan, B. Paul, Harris, Claire L.

“…Key Points Complement is a key component of immunity with crucial inflammatory and opsonic properties; inappropriate activation of complement triggers or…”
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What makes a centromere? by Talbert, Paul B., Henikoff, Steven

“…Centromeres are the eukaryotic chromosomal sites at which the kinetochore forms and attaches to spindle microtubules to orchestrate chromosomal segregation in…”
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Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification by Chidambaranathan-Reghupaty, Saranya, Fisher, Paul B, Sarkar, Devanand

“…Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with bleak outcome. According to National Cancer Institute's SEER…”
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Link between body fat and the timing of puberty by Kaplowitz, Paul B

“…Several recent studies suggest that the timing of the onset of puberty in girls has become earlier over the past 30 years, and there is strong evidence that…”
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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung by Pezzulo, Alejandro A., Tang, Xiao Xiao, Hoegger, Mark J., Abou Alaiwa, Mahmoud H., Ramachandran, Shyam, Moninger, Thomas O., Karp, Phillip H., Wohlford-Lenane, Christine L., Haagsman, Henk P., van Eijk, Martin, Bánfi, Botond, Horswill, Alexander R., Stoltz, David A., McCray, Paul B., Welsh, Michael J., Zabner, Joseph

“…In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface…”
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High-Intensity Interval Training, Solutions to the Programming Puzzle: Part II: Anaerobic Energy, Neuromuscular Load and Practical Applications by Buchheit, Martin, Laursen, Paul B.

“…High-intensity interval training (HIT) is a well-known, time-efficient training method for improving cardiorespiratory and metabolic function and, in turn,…”
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Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression by Cash, Robin F.H., Weigand, Anne, Zalesky, Andrew, Siddiqi, Shan H., Downar, Jonathan, Fitzgerald, Paul B., Fox, Michael D.

“…Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is limited in that the optimal therapeutic target remains unknown. Early…”
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Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome by Meyerholz, David K, Lambertz, Allyn M, McCray, Jr, Paul B

“…Dipeptidyl peptidase 4 (DPP4, CD26), a type II transmembrane ectopeptidase, is the receptor for the Middle Eastern respiratory syndrome coronavirus (MERS-CoV)…”
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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice by Zheng, Jian, Wong, Lok-Yin Roy, Li, Kun, Verma, Abhishek Kumar, Ortiz, Miguel E., Wohlford-Lenane, Christine, Leidinger, Mariah R., Knudson, C. Michael, Meyerholz, David K., McCray, Paul B., Perlman, Stanley

“…The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality. Although much has been learned in the first…”
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