Search Results - "Paul, Aditya S"

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum by Kumar, Sudhir, Kumar, Manish, Ekka, Roseleen, Dvorin, Jeffrey D., Paul, Aditya S., Madugundu, Anil K., Gilberger, Tim, Gowda, Harsha, Duraisingh, Manoj T., Keshava Prasad, T. S., Sharma, Pushkar

“…Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium…”
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Inhibition of malaria and babesiosis parasites by putative red blood cell targeting small molecules by Groomes, Patrice V, Paul, Aditya S, Duraisingh, Manoj T

“…Chemotherapies for malaria and babesiosis frequently succumb to the emergence of pathogen-related drug-resistance. Host-targeted therapies are thought to be…”
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Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes by Paul, Aditya S., Miliu, Alexandra, Paulo, Joao A., Goldberg, Jonathan M., Bonilla, Arianna M., Berry, Laurence, Seveno, Marie, Braun-Breton, Catherine, Kosber, Aziz L., Elsworth, Brendan, Arriola, Jose S. N., Lebrun, Maryse, Gygi, Steven P., Lamarque, Mauld H., Duraisingh, Manoj T.

“…Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic…”
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Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans by Paul, Aditya S., Saha, Sudeshna, Engelberg, Klemens, Jiang, Rays H.Y., Coleman, Bradley I., Kosber, Aziz L., Chen, Chun-Ti, Ganter, Markus, Espy, Nicole, Gilberger, Tim W., Gubbels, Marc-Jan, Duraisingh, Manoj T.

“…Apicomplexans invade a variety of metazoan host cells through mechanisms involving host cell receptor engagement and secretion of parasite factors…”
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Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes by Gubbels, Marc-Jan, Keroack, Caroline D, Dangoudoubiyam, Sriveny, Worliczek, Hanna L, Paul, Aditya S, Bauwens, Ciara, Elsworth, Brendan, Engelberg, Klemens, Howe, Daniel K, Coppens, Isabelle, Duraisingh, Manoj T

“…Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around…”
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Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites by Paul, Aditya S, Moreira, Cristina K, Elsworth, Brendan, Allred, David R, Duraisingh, Manoj T

“…The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic…”
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Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling by Sidik, Saima M., Hortua Triana, Miryam A., Paul, Aditya S., El Bakkouri, Majida, Hackett, Caroline G., Tran, Fanny, Westwood, Nicholas J., Hui, Raymond, Zuercher, William J., Duraisingh, Manoj T., Moreno, Silvia N.J., Lourido, Sebastian

“…The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca2+. Such fluxes are necessary for events like motility and egress…”
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Energetic Requirements for Processive Elongation of Actin Filaments by FH1FH2-formins by Paul, Aditya S., Pollard, Thomas D.

“…Formin-homology (FH) 2 domains from formin proteins associate processively with the barbed ends of actin filaments through many rounds of actin subunit…”
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Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum by Engelberg, Klemens, Paul, Aditya S, Prinz, Boris, Kono, Maya, Ching, Wilhelm, Heincke, Dorothee, Dobner, Thomas, Spielmann, Tobias, Duraisingh, Manoj T, Gilberger, Tim-Wolf

“…Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand…”
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Host–parasite interactions that guide red blood cell invasion by malaria parasites by Paul, Aditya S, Egan, Elizabeth S, Duraisingh, Manoj T

“…PURPOSE OF REVIEWMalaria is caused by the infection and proliferation of parasites from the genus Plasmodium in red blood cells (RBCs). A free Plasmodium…”
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Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance by Keroack, Caroline D, Elsworth, Brendan, Tennessen, Jacob A, Paul, Aditya S, Hua, Renee, Ramirez-Ramirez, Luz, Ye, Sida, Moreira, Cristina K, Meyers, Marvin J, Zarringhalam, Kourosh, Duraisingh, Manoj T

“…is an emerging zoonosis and widely distributed veterinary infection caused by 100+ species of parasites. The diversity of parasites and the lack of specific…”
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Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry by Paul, Aditya S., Duraisingh, Manoj T.

“…Proliferation of malaria parasites in a host requires mechanisms to spread between red blood cells (RBCs). We discuss here the implications for biology and…”
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A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion by Egan, Elizabeth S., Jiang, Rays H. Y., Moechtar, Mischka A., Barteneva, Natasha S., Weekes, Michael P., Nobre, Luis V., Gygi, Steven P., Paulo, Joao A., Frantzreb, Charles, Tani, Yoshihiko, Takahashi, Junko, Watanabe, Seishi, Goldberg, Jonathan, Paul, Aditya S., Brugnara, Carlo, Root, David E., Wiegand, Roger C., Doench, John G., Duraisingh, Manoj T.

“…Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, which precludes genetic manipulation in the…”
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Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination by Lim, Caeul, Dankwa, Selasi, Paul, Aditya S, Duraisingh, Manoj T

“…and account for most of the mortality and morbidity associated with malaria in humans. Research and control efforts have focused on infections caused by and ,…”
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Review of the mechanism of processive actin filament elongation by formins by Paul, Aditya S., Pollard, Thomas D.

“…We review recent structural and biophysical studies of the mechanism of action of formins, proteins that direct the assembly of unbranched actin filaments for…”
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Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony by Ganter, Markus, Goldberg, Jonathan M., Dvorin, Jeffrey D., Paulo, Joao A., King, Jonas G., Tripathi, Abhai K., Paul, Aditya S., Yang, Jing, Coppens, Isabelle, Jiang, Rays H. Y., Elsworth, Brendan, Baker, David A., Dinglasan, Rhoel R., Gygi, Steven P., Duraisingh, Manoj T.

“…Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection 1…”
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A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion by Baum, Jake, Tonkin, Christopher J, Paul, Aditya S, Rug, Melanie, Smith, Brian J, Gould, Sven B, Richard, Dave, Pollard, Thomas D, Cowman, Alan F

“…Malaria parasites invade host cells using actin-based motility, a process requiring parasite actin filament nucleation and polymerization. Malaria and other…”
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Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony by Ganter, Markus, Goldberg, Jonathan M., Dvorin, Jeffrey D., Paulo, Joao A., King, Jonas G., Tripathi, Abhai K., Paul, Aditya S., Yang, Jing, Coppens, Isabelle, Jiang, Rays H. Y., Elsworth, Brendan, Baker, David A., Dinglasan, Rhoel R., Gygi, Steven P., Duraisingh, Manoj T.

“…Nature Microbiology 2, 17017 (2017); published online 17 February 2017; corrected 6 March 2017. In the version of this Letter originally published, the in-text…”
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The Role of the FH1 Domain and Profilin in Formin-Mediated Actin-Filament Elongation and Nucleation by Paul, Aditya, Pollard, Thomas

“…Formin proteins nucleate actin filaments de novo and stay associated with the growing barbed end. Whereas the formin-homology (FH) 2 domains mediate processive…”
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Energetic Requirements for Processive Elongation of Actin Filaments by FH1FH2-forminsS by Paul, Aditya S., Pollard, Thomas D.

“…Formin-homology (FH) 2 domains from formin proteins associate processively with the barbed ends of actin filaments through many rounds of actin subunit…”
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