Search Results - "Paudel, Sanjita"

Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis by Na, Ann-Yae, Paudel, Sanjita, Choi, Soyoung, Lee, Jun Hyung, Kim, Min-Sik, Bae, Jong-Sup, Lee, Sangkyu

“…Sepsis-induced liver dysfunction (SILD) is a common event and is strongly associated with mortality. Establishing a causative link between protein…”
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Discovery and Validation of a Novel Step Catalyzed by OsF3H in the Flavonoid Biosynthesis Pathway by Jan, Rahmatullah, Asaf, Sajjad, Paudel, Sanjita, Lubna, Lee, Sangkyu, Kim, Kyung-Min

“…Kaempferol and quercetin are the essential plant secondary metabolites that confer huge biological functions in the plant defense system. In this study,…”
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Novel Time-dependent Multi-omics Integration in Sepsis-associated Liver Dysfunction by Na, Ann-Yae, Lee, Hyojin, Min, Eun Ki, Paudel, Sanjita, Choi, So Young, Sim, HyunChae, Liu, Kwang-Hyeon, Kim, Ki-Tae, Bae, Jong-Sup, Lee, Sangkyu

“…The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease processes. However, it…”
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Extracellular Vesicles Act as Nano-Transporters of Tyrosine Kinase Inhibitors to Revert Iodine Avidity in Thyroid Cancer by Rajendran, Ramya Lakshmi, Paudel, Sanjita, Gangadaran, Prakash, Oh, Ji Min, Oh, Eun Jung, Hong, Chae Moon, Lee, Sangkyu, Chung, Ho Yun, Lee, Jaetae, Ahn, Byeong-Cheol

“…A new approach for using extracellular vesicles (EVs) to deliver tyrosine kinase inhibitors (TKIs) to enhance iodine avidity in radioactive iodine-refractory…”
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Identification of Histone Lysine Acetoacetylation as a Dynamic Post‐Translational Modification Regulated by HBO1 by Gao, Yan, Sheng, Xinlei, Tan, Doudou, Kim, SunJoo, Choi, Soyoung, Paudel, Sanjita, Lee, Taeho, Yan, Cong, Tan, Minjia, Kim, Kyu Min, Cho, Sam Seok, Ki, Sung Hwan, Huang, He, Zhao, Yingming, Lee, Sangkyu

“…Ketone bodies have long been known as a group of lipid‐derived alternative energy sources during glucose shortages. Nevertheless, the molecular mechanisms…”
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Identification of HYIpro-3-1 Metabolites, a Novel Anti-Inflammatory Compound, in Human Liver Microsomes by Quadrupole-Orbitrap High-Resolution Mass Spectrometry by Honghao Bai, Younah Kim, Sanjita Paudel, Eung-Seok Lee, Sangkyu Lee

“…HYIpro-3-1 is an adjuvant for preventing or treating inflammatory growth diseases. In this study, we identified the metabolic pathway of HYIpro-3-1 in human…”
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Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators by Paudel, Sanjita, Shrestha, Aarajana, Cho, Piljoung, Shrestha, Riya, Kim, Younah, Lee, Taeho, Kim, Ju-Hyun, Jeong, Tae Cheon, Lee, Eung-Seok, Lee, Sangkyu

“…Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory…”
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Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation by Shrestha, Riya, Cho, Pil Joung, Paudel, Sanjita, Shrestha, Aarajana, Kang, Mi Jeong, Jeong, Tae Cheon, Lee, Eung-Seok, Lee, Sangkyu

“…Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form…”
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Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol by Cho, Pil Joung, Paudel, Sanjita, Lee, Doohyun, Jin, Yun Ji, Jo, GeunHyung, Jeong, Tae Cheon, Lee, Sangkyu, Lee, Taeho

“…Osthenol is a prenylated coumarin isolated from the root of and , and is an -demethylated metabolite of osthole in vivo. Its various pharmacological effects…”
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Elevational Trends in Usnic Acid Concentration of Lichen Parmelia flexilis in Relation to Temperature and Precipitation by Bishnu Prasad Neupane, Komal Prasad Malla, Anil Gautam, Dinesh Chaudhary, Sanjita Paudel, Sangita Timsina, Nirmala Jamarkattel

“…Usnic acid contents in acetone extracts of 31 samples of lichen Parmelia flexilis collected from different altitudes were identified using thin layer…”
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Identification of HYIpro-3-1 Metabolites, a Novel Anti-Inflammatory Compound, in Human Liver Microsomes by Quadrupole-Orbitrap High-Resolution Mass Spectrometry by Bai, Honghao, Kim, Younah, Paudel, Sanjita, Lee, Eung-Seok, Lee, Sangkyu

“…HYIpro-3-1 is an adjuvant for preventing or treating inflammatory growth diseases. In this study, we identified the metabolic pathway of HYIpro-3-1 in human…”
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Selective inhibitory effects of suberosin on CYP1A2 in human liver microsomes by Paudel, Sanjita, Jo, Hyoje, Lee, Taeho, Lee, Sangkyu

“…Suberosin is a natural phytoconstituent isolated from Citropsis articulata, especially employed for its anticoagulant properties. Although metabolic studies…”
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Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles by Kong, Mingyu, Hong, Da Hee, Paudel, Sanjita, Yoon, Na Eun, Jung, Byung Hwa, Kim, Myounghoi, Kim, Tae Hun, Jeong, Jaemin, Choi, Dongho, Lee, Hyunbeom

“…Although there are several studies in the development of various human cancers, the role of exosomes is poorly understood in the progression of gallbladder…”
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Effect of Food Insecurity on Nutritional Status of Reproductive Age Women of Squatter Settlement of Pokhara Metropolitan, Kaski, Nepal by Saru Paudel, Tulsi Ram Bhandari, Sanjita Paudel, Nabaraj Paudel

“…Background: Food insecurity is the situation that exists when all people, at all times, didn’t have secure access to enough amounts of safe and nutritious food…”
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Integrative Profiling of Lysine Acylome in Sepsis-Induced Liver Injury by Na, Ann-Yae, Choi, So Young, Paudel, Sanjita, Bae, Jong-Sup, Tan, Minjia, Lee, Sangkyu

“…Sepsis is one of the life-threatening diseases worldwide. Despite the continuous progress in medicine, the specific mechanism of sepsis remains unclear. A key…”
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Himalayan honey loaded iron oxide nanoparticles: synthesis, characterization and study of antioxidant and antimicrobial activities by Neupane, Bishnu Prasad, Chaudhary, Dinesh, Paudel, Sanjita, Timsina, Sangita, Chapagain, Bipin, Jamarkattel, Nirmala, Tiwari, Bishnu Raj

“…Himalayan honey, a natural product of wild honey bees found in the Himalayan mountains of Nepal, has been used in medicine for many years. The successful…”
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Identification of suberosin metabolites in human liver microsomes by high‐performance liquid chromatography combined with high‐resolution quadrupole–orbitrap mass spectrometer by Paudel, Sanjita, Kim, Younah, Choi, Su Min, Kim, Ju‐Hyun, Bae, Jong‐Sup, Lee, Taeho, Lee, Sangkyu

“…Suberosin is a natural prenylated coumarin derivative isolated from Citropsis articulata. It has various pharmacological properties, especially as an…”
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Identification of sulfonyl‐loxoprofen as novel phase 2 conjugate in rat by Shrestha, Riya, Paudel, Sanjita, Cho, Piljoung, Shrestha, Aarajana, Jeong, Tae Cheon, Lee, Eung‐Seok, Lee, Taeho, Lee, Sangkyu

“…Loxoprofen is a prodrug that exerts strong analgesic and anti‐inflammatory effects through its active trans‐alcohol metabolite, which is produced in the liver…”
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