Search Results - "Paudel, H K"

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments by Paudel, H K, Lew, J, Ali, Z, Wang, J H

“…Brain proline-directed protein kinase (BPDK), which contains a catalytic subunit homologous to and displaying site-specific phosphorylation similar to p34cdc2…”
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14-3-3 zeta Is an Effector of Tau Protein Phosphorylation by Hashiguchi, M, Sobue, K, Paudel, H K

“…Neurofibrillary tangles associated with Alzheimer's disease are composed mainly of paired helical filaments that are formed by the aggregation of abnormally…”
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Cyclin-Dependent Protein Kinase 5 Primes Microtubule-Associated Protein Tau Site-Specifically for Glycogen Synthase Kinase 3β by Li, Tong, Hawkes, Cheryl, Qureshi, Hamid Y, Kar, Satyabrata, Paudel, Hemant K

“…In the preceding paper, we showed that GSK3β phosphorylates tau at S202, T231, S396, and S400 in vivo. Phosphorylation of S202 occurs without priming…”
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Phosphorylase kinase phosphorylates the calmodulin-binding regulatory regions of neuronal tissue-specific proteins B-50 (GAP-43) and neurogranin by PAUDEL, H. K, ZWIERS, H, WANG, J. H

“…Neuronal tissue-specific proteins B-50 (GAP-43, neuromodulin) and neurogranin are phosphorylated by phosphorylase kinase with stoichiometries of 0.4 and 0.5…”
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The topography and subcellular distribution of mitogen-activated protein kinase kinase 1 (MEK1) in adult rat brain and differentiating PC12 cells by SCHIPPER, H. M, AGARWAL-MAWAL, A, PAUDEL, H. K

“…Mitogen-activated protein kinase signal transduction pathway involved in the regulation of proliferation and differentiation of various mammalian cells…”
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Glycogen Synthase Kinase-3β Is Complexed with Tau Protein in Brain Microtubules by Sun, Wei, Qureshi, Hamid Y., Cafferty, Patrick W., Sobue, Kazuya, Agarwal-Mawal, Alka, Neufield, Katherine D., Paudel, Hemant K.

“…In Alzheimer's disease, microtubule-associated protein tau is hyperphosphorylated by an unknown mechanism and is aggregated into paired helical filaments…”
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Inhibition of the catalytic subunit of phosphorylase kinase by its alpha/beta subunits by Paudel, H K, Carlson, G M

“…The subunits of phosphorylase kinase are separated and isolated in high yield by gel filtration chromatography in pH 3.3 phosphate buffer containing 8 M urea…”
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The ATPase activity of phosphorylase kinase is regulated in parallel with its protein kinase activity by PAUDEL, H. K, CARLSON, G. M

“…Phosphorylase kinase from rabbit skeletal muscle has been found to have an intrinsic ATPase activity that occurs at a rate approximately 0.2% of that of its…”
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Comparison of the three primary structures of deoxyribonuclease isolated from bovine, ovine, and porcine pancreas. Derivation of the amino acid sequence of ovine DNase and revision of the previously published amino acid sequence of bovine DNase by Paudel, H K, Liao, T H

“…Based on the published bovine DNase sequence (Liao, T.-H., Salnikow, J., Moore, S., and Stein, W. H. (1973) J. Biol. Chem. 248, 1489-1495), the ovine DNase…”
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Functional and Structural Similarities Between the Inhibitory Region of Troponin I Coded by Exon VII and the Calmodulin-Binding Regulatory Region of the Catalytic Subunit of Phosphorylase Kinase by Paudel, Hemant K., Carlson, Gerald M.

“…A sequence homology has been noted between the carboxyl quarter of the catalytic γ subunit of phosphorylase kinase and the region of troponin I coded by exon…”
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Heparin-induced Conformational Change in Microtubule-associated Protein Tau as Detected by Chemical Cross-linking and Phosphopeptide Mapping by Paudel, H K, Li, W

“…In Alzheimer’s disease, microtubule-associated protein tau becomes abnormally phosphorylated and aggregates into paired helical filaments. Sulfated…”
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Neuronal Cdc2-like Protein Kinase (Cdk5/p25) Is Associated with Protein Phosphatase 1 and Phosphorylates Inhibitor-2 by Agarwal-Mawal, Alka, Paudel, Hemant K.

“…Protein phosphatase 1 (PP1) is complexed with inhibitor 2 (I-2) in the cytosol. In rabbit muscle extract PP1·I-2 is activated upon preincubation with ATP/Mg…”
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Phosphorylation by Neuronal cdc2-like Protein Kinase Promotes Dimerization of Tau Protein in Vitro by Paudel, Hemant K.

“…In Alzheimer's disease, the microtubule-associated protein tau forms paired helical filaments (PHFs) that are the major structural component of neurofibrillary…”
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Purification, characterization, and the complete amino acid sequence of porcine pancreatic deoxyribonuclease by Paudel, H K, Liao, T H

“…Porcine pancreatic DNase has been purified to homogeneity. The polypeptide exhibits a single band of Mr = 34,000 on sodium dodecyl sulfate-polyacrylamide gel…”
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Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau by Sobue, Kazuya, Agarwal-Mawal, Alka, Li, Wei, Sun, Wei, Miura, Yutaka, Paudel, Hemant K.

“…Neuronal Cdc2-like protein kinase (NCLK), a ∼58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A.,…”
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The quaternary structure of phosphorylase kinase as influenced by low concentrations of urea. Evidence suggesting a structural role for calmodulin by Paudel, H K, Carlson, G M

“…Skeletal-muscle phosphorylase kinase is a hexadecameric oligomer composed of equivalent amounts of four different subunits, (alpha beta gamma delta)4. The…”
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Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2 by LEW, J, WINKFEIN, R. J, PAUDEL, H. K, WANG, J. H

“…The carboxyl-terminal regions of neurofilament high (NF-H) and middle (NF-M) molecular weight proteins have been suggested to be phosphorylated in vivo by a…”
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The model calmodulin-binding peptide melittin inhibits phosphorylase kinase by interacting with its catalytic center by Paudel, Hemant K, Xu, Yi Hong, Jarrett, Harry W, Carlson, Gerald M

“…The inhibition by melittin, a model calmodulin-binding peptide, of phosphorylase kinase, which contains an intrinsic calmodulin subunit, has been characterized…”
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Involvement of a histidine residue in the interaction between membrane-anchoring protein (QPs) and succinate dehydrogenase in mitochondrial succinate-ubiquinone reductase by Paudel, H K, Yu, L, Yu, C A

“…The involvement of a histidine residue of the membrane-anchoring protein (QPs) fraction in reconstitution of succinate dehydrogenase to form…”
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Renaturation of phosphorylase kinase activity from sodium dodecyl sulfate-polyacrylamide gels by Paudel, H K, Carlson, G M

“…Phosphorylase kinase activity is renatured and detected in situ following electrophoresis of the denatured holoenzyme in a sodium dodecyl…”
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