Search Results - "Paudel, B Bishal"

Metabolic plasticity meets gene regulation by Paudel, B. Bishal, Quarantaa, Vito

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Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state by Wang, Lixin, Paudel, B. Bishal, McKnight, R. Anthony, Janes, Kevin A.

“…Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial…”
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An unbiased metric of antiproliferative drug effect in vitro by Harris, Leonard A, Frick, Peter L, Garbett, Shawn P, Hardeman, Keisha N, Paudel, B Bishal, Lopez, Carlos F, Quaranta, Vito, Tyson, Darren R

“…Conventional metrics for assessing antiproliferative drug effect have time-dependent biases that may skew results. The drug-induced proliferation rate can be…”
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Proteome-wide copy-number estimation from transcriptomics by Sweatt, Andrew J, Griffiths, Cameron D, Groves, Sarah M, Paudel, B Bishal, Wang, Lixin, Kashatus, David F, Janes, Kevin A

“…Protein copy numbers constrain systems-level properties of regulatory networks, but proportional proteomic data remain scarce compared to RNA-seq. We related…”
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An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells by Paudel, B Bishal, Lewis, Joshua E, Hardeman, Keisha N, Hayford, Corey E, Robbins, Charles J, Stauffer, Philip E, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Kemp, Melissa L, Quaranta, Vito

“…Melanomas harboring mutations can be treated with inhibitors ( i), but responses are varied and tumor recurrence is inevitable. Here we used an integrative…”
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Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype by Jia, Dongya, Paudel, B. Bishal, Hayford, Corey E., Hardeman, Keisha N., Levine, Herbert, Onuchic, José N., Quaranta, Vito

“…Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated…”
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Dynamics of drug response informs rational combination regimens by Paudel, B Bishal, Quaranta, Vito

“…Metabolic plasticity in cancer has been linked to the development of drug-tolerant populations. In this issue of , Goldman integrate metabolic plasticity with…”
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Quantifying Drug Combination Synergy along Potency and Efficacy Axes by Meyer, Christian T, Wooten, David J, Paudel, B Bishal, Bauer, Joshua, Hardeman, Keisha N, Westover, David, Lovly, Christine M, Harris, Leonard A, Tyson, Darren R, Quaranta, Vito

“…Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing doses (synergistic potency) and improve outcomes by…”
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A Nonquiescent “Idling” Population State in Drug-Treated, BRAF-Mutated Melanoma by Paudel, B. Bishal, Harris, Leonard A., Hardeman, Keisha N., Abugable, Arwa A., Hayford, Corey E., Tyson, Darren R., Quaranta, Vito

“…Targeted therapy is an effective standard of care in BRAF-mutated malignant melanoma. However, the duration of tumor remission varies unpredictably among…”
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Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition by Hardeman, Keisha N., Peng, Chengwei, Paudel, Bishal B., Meyer, Christian T., Luong, Thong, Tyson, Darren R., Young, Jamey D., Quaranta, Vito, Fessel, Joshua P.

“…Dysregulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and expanding proliferation. Given many BRAF-mutated…”
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Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation by Frick, Peter L., Paudel, Bishal B., Tyson, Darren R., Quaranta, Vito

“…The dynamics of heterogeneous clonal lineages within a cell population, in aggregate, shape both normal and pathological biological processes. Studies of…”
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Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes by Paudel, B. Bishal, Tan, Su-Fern, Fox, Todd E., Ung, Johnson, Golla, Upendarrao, Shaw, Jeremy J. P., Dunton, Wendy, Lee, Irene, Fares, Wisam A., Patel, Satyam, Sharma, Arati, Viny, Aaron D., Barth, Brian M., Tallman, Martin S., Cabot, Myles, Garrett-Bakelman, Francine E., Levine, Ross L., Kester, Mark, Feith, David J., Claxton, David, Janes, Kevin A., Loughran, Thomas P.

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Abstract 670: Molecular basis of the idling state uncovers vulnerabilities suitable to sequential targeting in melanoma by Hayford, Corey E., Paudel, Bishal B., Harris, Leonard A., Hardeman, Keisha N., Tyson, Darren R., Quaranta, Vito

“…Abstract Recent published work from the lab identified a novel “idling” population state in the response of BRAF-mutant melanoma cancer cell lines to BRAF…”
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Abstract 2894: Overcoming intrinsic resistance to BRAF -inhibitors by modulating redox balance in BRAF -mutated melanoma cells by Paudel, B. Bishal, Harris, Leonard A., Hardeman, Keisha N., Hayford, Corey E., Meyer, Christian T., Abugable, Arwa A., Tyson, Darren R., Fessel, Joshua P., Quaranta, Vito

“…Abstract Post-resistant tumor analyses or static measurements provide most of our current knowledge of tumor recurrence. Unfortunately, these studies neither…”
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Abstract 4947: Uncovering the molecular basis for clinically relevant sphingolipidomic subtypes in acute myeloid leukemia by Paudel, B Bishal, Tan, Su-Fern, Ung, Johnson, Claxton, David, Feith, David J., Loughran, Thomas P., Janes, Kevin A.

“…Abstract Acute myeloid leukemia (AML) has been extensively studied at the genomic level, resulting in various genomic classifications. Despite the progress,…”
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An unbiased metric of antiproliferative drug effect in vitro by Harris, Leonard A, Frick, Peter L, Garbett, Shawn P, Hardeman, Keisha N, Paudel, B. Bishal, Lopez, Carlos F, Quaranta, Vito, Tyson, Darren R

“…Nature Methods 13, 497-500 (2016) In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical…”
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Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation: QUANTIFYING PERTURBATION-INDUCED CLONAL FITNESS by Frick, Peter L., Paudel, Bishal B., Tyson, Darren R., Quaranta, Vito

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Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Patients With Obesity and HFpEF by Carbone, Salvatore, PhD, Billingsley, Hayley E., RD, Canada, Justin M., PhD, Kadariya, Dinesh, MD, Medina de Chazal, Horacio, MD, Rotelli, Brando, BA, Potere, Nicola, MD, Paudel, Bishal, BS, Markley, Roshi, MD, Dixon, Dave L., PharmD, Trankle, Cory R., MD, Van Tassell, Benjamin W., PharmD, Celi, Francesco S., MD, MHSc, Abbate, Antonio, MD, PhD

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