Search Results - "Patton, S J"

A recombinant human enzyme for enhanced interstitial transport of therapeutics by Bookbinder, L.H., Hofer, A., Haller, M.F., Zepeda, M.L., Keller, G.-A., Lim, J.E., Edgington, T.S., Shepard, H.M., Patton, J.S., Frost, G.I.

“…Subcutaneously injected therapeutics must pass through the interstitial matrix of the skin in order to reach their intended targets. This complex,…”
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Developmental analysis of the ovarian tumor gene during Drosophila oogenesis by Rodesch, C, Geyer, P.K, Patton, J.S, Bae, E, Nagoshi, R.N

“…Severe alleles of the ovarian tumor (otu) and ovo genes result in female sterility in Drosophila melanogaster, producing adult ovaries that completely lack egg…”
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Interferons and Tumor Necrosis Factors Have Similar Catabolic Effects on 3T3 L1 Cells by Patton, John S., Shepard, H. Michael, Wilking, Helga, Lewis, Gail, Aggarwal, Bharat B., Eessalu, Thomas E., Gavin, Lawrence A., Grunfeld, Carl

“…The effect of a variety of cytokines on lipid metabolism in 3T3 L1 mouse fibroblasts and adipocytes was studied. Uptake of [3H]acetate by adipocytes and…”
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The lungs as a portal of entry for systemic drug delivery by Patton, John S, Fishburn, C Simone, Weers, Jeffry G

“…The lung is naturally permeable to all small-molecule drugs studied and to many therapeutic peptides and proteins. Absorption can be estimated using a simple…”
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Development of partial tolerance to the gastrointestinal effects of high doses or recombinant tumor necrosis factor-α in rodents by PATTON, J. S, PETERS, P. M, MCCABE, J, CRASE, D, HANSEN, S, CHEN, A. B, LIGGITT, D

“…Treatment of healthy rats and mice with a single intravenous injection of recombinant human tumor necrosis factor-alpha (rHuTNF-alpha) caused a dose-dependent…”
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Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs by KOHROGI, H, NADEL, J. A, MALFROY, B, GORMAN, C, BRIDENBAUGH, R, PATTON, J. S, BORSON, D. B

“…To determine whether recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11) prevents cough induced by exogenously applied and endogenously released…”
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Human Immunodeficiency Virus-Infected T Cells and Monocytes are Killed by Monoclonal Human Anti-gp41 Antibodies Coupled to Ricin A Chain by Till, M. A., Zolla-Pazner, S., Gorny, M. K., Patton, J. S., Uhr, J. W., Vitetta, E. S.

“…Two human monoclonal antibodies specific for the envelope glycoprotein (gp), gp41, of the human immunodeficiency virus were conjugated to deglycosylated ricin…”
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Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats by Debs, RJ, Fuchs, HJ, Philip, R, Montgomery, AB, Brunette, EN, Liggitt, D, Patton, JS, Shellito, JE

“…The recombinant cytokines IFN-gamma and TNF-alpha stimulate several macrophage-mediated functions important in host defense. However, systemic administration…”
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Robertsonian polymorphism in the marine gastropod, Nucella lapillus: advances in karyology using rDNA loci and NORs by Pascoe, P L, Patton, S J, Critcher, R, Dixon, D R

“…Previous studies of the Robertsonian polymorphism in the Atlantic dog-whelk, Nucella lapillus (2n = 26-36), have been limited by the inability to identify…”
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Genetic and molecular characterization of P element-induced mutations reveals that the Drosophila ovarian tumor gene has maternal activity and a variable null phenotype by Geyer, P.K. (University of Iowa, Iowa City, IA), Patton, J.S, Rodesch, C, Nagoshi, R.N

“…The mutations in the ovarian tumor (otu) gene arrest oogenesis at several stages in development. A series of deletion mutations in the otu region were…”
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Induction of monooxygenase activity in the intestine of spot (Leiostomus xanthurus), a marine teleost, by dietary polycyclic aromatic hydrocarbons by van Veld, P A, Stegeman, J J, Woodin, B R, Patton, J S, Lee, R F

“…The response of intestinal monooxygenases to dietary polycyclic aromatic hydrocarbon (PAH) exposure was evaluated in spot (Leiostomus xanthurus), a marine…”
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Inhibition of lipolysis by hydrocarbons and fatty alcohols by Ferreira, GC, Patton, JS

“…The hydrolysis of long-chain triglyceride by pancreatic lipase (EC 3.1.1.3) is inhibited by hydrophobic solutes that are dissolved in the fat. Solutes tested…”
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Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: an absorption model using the killifish by Vetter, R D, Carey, M C, Patton, J S

“…Benzo(a)pyrene (BP) was dissolved in dietary fat and fed in a single dose to killifish (Fundulus heteroclitus). Fluorescence microscopic examinations of small…”
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Pulmonary delivery of drugs for bone disorders by Patton, John S

“…As the population ages, osteoporosis becomes a growing public health concern. Current treatments provide patients with limited clinical improvement, numerous…”
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A reevaluation of the role of glycerol in carbon translocation in zooxanthellae-coelenterate symbiosis by BATTEY, J. F, PATTON, J. S

“…Glycerol has been traditionally viewed as the main form of carbon translocated from zooxanthellae to the coelenterate host. Most of this glycerol was…”
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Lipid synthesis and extrusion by freshly isolated zooxanthellae (symbiotic algae) by Patton, J.S, Burris, J.E

“…Zooxanthellae (symbiotic algae) from the same head of Stylophora pistillata were isolated at different times of the day over a period of 5 d and examined by…”
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Glycerol translocation in Condylactis gigantea by BATTEY, J. F, PATTON, J. S

“…Sodium cyanide (NaCN) was used to partially uncouple respiration and photosynthesis in the symbiotic sea anemone Condylactis gigantea . NaCN significantly…”
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Lipid droplets, medium of energy exchange in the symbiotic anemone Condylactis gigantea: a model coral polyp by KELLOGG, R. B, PATTON, J. S

“…The symbiotic sea anemone C. gigantea does not make a CaCO sub(3) skeleton, yet its lipid metabolism appears to be very similar to that of reef-building…”
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Cryopreservation and Methanol Effects on Burbot Sperm Motility and Egg Fertilization by Jensen, N. R., Zuccarelli, M. D., Patton, S. J., Williams, S. R., Ireland, S. C., Cain, K. D.

“…Cryopreservation of semen from North American burbot Lota lota maculosa was investigated and optimal methanol concentrations were determined for a conservation…”
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Similar bioavailability and lymphatic transport of benzo(a)pyrene when administered to rats in different amounts of dietary fat by Laher, J M, Rigler, M W, Vetter, R D, Barrowman, J A, Patton, J S

“…This study assessed the effect of concomitant lipid absorption on the bioavailability and lymphatic transport of benzo(a)pyrene (BP), a carcinogenic polycyclic…”
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