Search Results - "Patton, Austin"

Severe inbreeding, increased mutation load and gene loss-of-function in the critically endangered Devils Hole pupfish by Tian, David, Patton, Austin H, Turner, Bruce J, Martin, Christopher H

“…Small populations with limited range are often threatened by inbreeding and reduced genetic diversity, which can reduce fitness and exacerbate population…”
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A Dynamic Water Balance/Nonlinear Reservoir Model of a Perched Phreatic Aquifer–River System With Hydrogeologic Threshold Effects by O'Reilly, Andrew M., Holt, Robert M., Davidson, Gregg R., Patton, Austin C., Rigby, James R.

“…Heterogeneity in the hyporheic zone or near‐field geology can impart a threshold effect on groundwater‐surface water (GW‐SW) exchange. Variations in the…”
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Comparing Adaptive Radiations Across Space, Time, and Taxa by Gillespie, Rosemary G, Bennett, Gordon M, De Meester, Luc, Feder, Jeffrey L, Fleischer, Robert C, Harmon, Luke J, Hendry, Andrew P, Knope, Matthew L, Mallet, James, Martin, Christopher, Parent, Christine E, Patton, Austin H, Pfennig, Karin S, Rubinoff, Daniel, Schluter, Dolph, Seehausen, Ole, Shaw, Kerry L, Stacy, Elizabeth, Stervander, Martin, Stroud, James T, Wagner, Catherine, Wogan, Guinevere O U

“…Abstract Adaptive radiation plays a fundamental role in our understanding of the evolutionary process. However, the concept has provoked strong and differing…”
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Insights From Experiments With Rigor in an EvoBio Design Study by Rogers, Jen, Patton, Austin H., Harmon, Luke, Lex, Alexander, Meyer, Miriah

“…Design study is an established approach of conducting problem-driven visualization research. The academic visualization community has produced a large body of…”
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When adaptive radiations collide: Different evolutionary trajectories between and within island and mainland lizard clades by Patton, Austin H., Harmon, Luke J., del Rosario Castañeda, María, Frank, Hannah K., Donihue, Colin M., Herrelg, Anthony, Losos, Jonathan B.

“…Oceanic islands are known as test tubes of evolution. Isolated and colonized by relatively few species, islands are home to many of nature’s most renowned…”
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Navigating the Interface Between Landscape Genetics and Landscape Genomics by Storfer, Andrew, Patton, Austin, Fraik, Alexandra K

“…As next-generation sequencing data become increasingly available for non-model organisms, a shift has occurred in the focus of studies of the geographic…”
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Contemporary Demographic Reconstruction Methods Are Robust to Genome Assembly Quality: A Case Study in Tasmanian Devils by Patton, Austin H, Margres, Mark J, Stahlke, Amanda R, Hendricks, Sarah, Lewallen, Kevin, Hamede, Rodrigo K, Ruiz-Aravena, Manuel, Ryder, Oliver, McCallum, Hamish I, Jones, Menna E, Hohenlohe, Paul A, Storfer, Andrew

“…Abstract Reconstructing species’ demographic histories is a central focus of molecular ecology and evolution. Recently, an expanding suite of methods…”
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Hybridizing salamanders experience accelerated diversification by Patton, Austin H., Margres, Mark J., Epstein, Brendan, Eastman, Jon, Harmon, Luke J., Storfer, Andrew

“…Whether hybridization generates or erodes species diversity has long been debated, but to date most studies have been conducted at small taxonomic scales…”
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Reconstructing Squamate Biogeography in Afro-Arabia Reveals the Influence of a Complex and Dynamic Geologic Past by Tejero-Cicuéndez, Héctor, Patton, Austin H, Caetano, Daniel S, Šmíd, Jiří, Harmon, Luke J, Carranza, Salvador

“…Abstract The geographic distribution of biodiversity is central to understanding evolutionary biology. Paleogeographic and paleoclimatic histories often help…”
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Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation by Patton, Austin H, Richards, Emilie J, Gould, Katelyn J, Buie, Logan K, Martin, Christopher H

“…Estimating the complex relationship between fitness and genotype or phenotype (i.e. the adaptive landscape) is one of the central goals of evolutionary…”
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Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection by Kozakiewicz, Christopher P, Fraik, Alexandra K, Patton, Austin H, Ruiz-Aravena, Manuel, Hamilton, David G, Hamede, Rodrigo, McCallum, Hamish, Hohenlohe, Paul A, Margres, Mark J, Jones, Menna E, Storfer, Andrew

“…Transmissible cancers lie at the intersection of oncology and infectious disease, two traditionally divergent fields for which gene expression studies are…”
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A transmissible cancer shifts from emergence to endemism in Tasmanian devils by Patton, Austin H, Lawrance, Matthew F, Margres, Mark J, Kozakiewicz, Christopher P, Hamede, Rodrigo, Ruiz-Aravena, Manuel, Hamilton, David G, Comte, Sebastien, Ricci, Lauren E, Taylor, Robyn L, Stadler, Tanja, Leaché, Adam, McCallum, Hamish, Jones, Menna E, Hohenlohe, Paul A, Storfer, Andrew

“…Emerging infectious diseases pose one of the greatest threats to human health and biodiversity. Phylodynamics is often used to infer epidemiological parameters…”
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Contemporary and historical selection in Tasmanian devils ( Sarcophilus harrisii ) support novel, polygenic response to transmissible cancer by Stahlke, Amanda R., Epstein, Brendan, Barbosa, Soraia, Margres, Mark J., Patton, Austin H., Hendricks, Sarah A., Veillet, Anne, Fraik, Alexandra K., Schönfeld, Barbara, McCallum, Hamish I., Hamede, Rodrigo, Jones, Menna E., Storfer, Andrew, Hohenlohe, Paul A.

“…Tasmanian devils ( Sarcophilus harrisii ) are evolving in response to a unique transmissible cancer, devil facial tumour disease (DFTD), first described in…”
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Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation by Margres, Mark J, Ruiz-Aravena, Manuel, Hamede, Rodrigo, Chawla, Kusum, Patton, Austin H, Lawrance, Matthew F, Fraik, Alexandra K, Stahlke, Amanda R, Davis, Brian W, Ostrander, Elaine A, Jones, Menna E, McCallum, Hamish, Paddison, Patrick J, Hohenlohe, Paul A, Hockenbery, David, Storfer, Andrew

“…Abstract Spontaneous cancer regression in humans is uncommon, but understanding the mechanisms is key for advancing treatment. Using Devil Facial Tumor Disease…”
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Varying Intensities of Introgression Obscure Incipient Venom-Associated Speciation in the Timber Rattlesnake ( Crotalus horridus ) by Margres, Mark J, Wray, Kenneth P, Sanader, Dragana, McDonald, Preston J, Trumbull, Lauren M, Patton, Austin H, Rokyta, Darin R

“…Ecologically divergent selection can lead to the evolution of reproductive isolation through the process of ecological speciation, but the balance of…”
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Comparative landscape genetics reveals differential effects of environment on host and pathogen genetic structure in Tasmanian devils (Sarcophilus harrisii) and their transmissible tumour by Kozakiewicz, Christopher P., Ricci, Lauren, Patton, Austin H., Stahlke, Amanda R., Hendricks, Sarah A., Margres, Mark J., Ruiz‐Aravena, Manuel, Hamilton, David G., Hamede, Rodrigo, McCallum, Hamish, Jones, Menna E., Hohenlohe, Paul A., Storfer, Andrew

“…Genetic structure in host species is often used to predict disease spread. However, host and pathogen genetic variation may be incongruent. Understanding…”
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Telomere Length is a Susceptibility Marker for Tasmanian Devil Facial Tumor Disease by Smith, Lane E., Jones, Menna E., Hamede, Rodrigo, Risques, Rosana, Patton, Austin H., Carter, Patrick A., Storfer, Andrew

“…Telomeres protect chromosomes from degradation during cellular replication. In humans, it is well-documented that excessive telomere degradation is one…”
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The devil is in the details: Genomics of transmissible cancers in Tasmanian devils by Storfer, Andrew, Hohenlohe, Paul A, Margres, Mark J, Patton, Austin, Fraik, Alexandra K, Lawrance, Matthew, Ricci, Lauren E, Stahlke, Amanda R, McCallum, Hamish I, Jones, Menna E

“…[...]DFT1 is generally composed of pleomorphic round cells in bundles, whereas DFT2 is typically characterized by pleomorphic sheets of cells [9]. [...]DFT2…”
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Tipping the Scales: The Migration-Selection Balance Leans toward Selection in Snake Venoms by Margres, Mark J, Patton, Austin, Wray, Kenneth P, Hassinger, Alyssa T B, Ward, Micaiah J, Lemmon, Emily Moriarty, Lemmon, Alan R, Rokyta, Darin R

“…The migration-selection interaction is the strongest determinant of whether a beneficial allele increases in frequency within a population. Results of…”
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The Genomic Basis of Tumor Regression in Tasmanian Devils (Sarcophilus harrisii) by Margres, Mark J, Ruiz-Aravena, Manuel, Hamede, Rodrigo, Jones, Menna E, Lawrance, Matthew F, Hendricks, Sarah A, Patton, Austin, Davis, Brian W, Ostrander, Elaine A, McCallum, Hamish, Hohenlohe, Paul A, Storfer, Andrew

“…Understanding the genetic basis of disease-related phenotypes, such as cancer susceptibility, is crucial for the advancement of personalized medicine. Although…”
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