Search Results - "Patterson, S. D."

Experiences with Learning and Confirming in Drug and Biological Development by Patterson, S D

“…Since the 1997 landmark article by Dr. Lewis Sheiner in Clinical Pharmacology & Therapeutics, biopharmaceutical development in phases I–IIA has become more…”
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Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition by Patterson, S D, Spahr, C S, Daugas, E, Susin, S A, Irinopoulou, T, Koehler, C, Kroemer, G

“…Mitochondrial membrane permeabilization is a rate-limiting step of cell death. This process is, at least in part, mediated by opening of the permeability…”
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Arthroplasty with a Metal Radial Head for Unreconstructible Fractures of the Radial Head by Moro, Jaydeep K, Werier, Joel, MacDermid, Joy C, Patterson, Stuart D, King, Graham J.W

“…BackgroundTreatment of unreconstructible comminuted fractures of the radial head remains controversial. There is limited information on the outcome of…”
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The C-terminal domain of RNA polymerase II couples mRNA processing to transcription by McCracken, Susan, Fong, Nova, Yankulov, Krassimir, Ballantyne, Scott, Pan, Guohua, Greenblatt, Jack, Patterson, Scott D, Wickens, Marvin, Bentley, David L

“…Messenger RNA is produced by RNA polymerase II (pol II) transcription, followed by processing of the primary transcript. Transcription, splicing and…”
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Ligamentous Stabilizers Against Posterolateral Rotatory Instability of the Elbow by Dunning, Cynthia E, Zarzour, Zane D.S, Patterson, Stuart D, Johnson, James A, King, Graham J.W

“…BackgroundThe lateral ulnar collateral ligament, the entire lateral collateral ligament complex, and the overlying extensor muscles have all been suggested as…”
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Interface pressure, perceptual, and mean arterial pressure responses to different blood flow restriction systems by Hughes, L., Rosenblatt, B., Gissane, C., Paton, B., Patterson, S. D.

“…This study examined the cuff to limb interface pressure during blood flow restriction (BFR), and the perceptual and mean arterial pressure responses, in…”
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Functional Outcome of Semiconstrained Total Elbow Arthroplasty by Hildebrand, Kevin A, Patterson, Stuart D, Regan, William D, MacDermid, Joy C, King, Graham J.W

“…BackgroundThe objective of the present study was to review the results of primary total elbow arthroplasty with use of the Coonrad-Morrey prosthesis. Two…”
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Metallic radial head arthroplasty improves valgus stability of the elbow by King, G J, Zarzour, Z D, Rath, D A, Dunning, C E, Patterson, S D, Johnson, J A

“…The stabilizing influence of radial head arthroplasty was studied in eight medial collateral ligament deficient anatomic specimen elbows. An elbow testing…”
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NASA’s satellite laser ranging systems for the twenty-first century by McGarry, J. F., Hoffman, E. D., Degnan, J. J., Cheek, J. W., Clarke, C. B., Diegel, I. F., Donovan, H. L., Horvath, J. E., Marzouk, M., Nelson, A. R., Patterson, D. S., Ricklefs, R. L., Shappirio, M. D., Wetzel, S. L., Zagwodzki, T. W.

“…For over 40 years, NASA’s global network of satellite laser ranging (SLR) stations has provided a significant percentage of the global orbital data used to…”
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Acute elbow dislocations: simple and complex by Hildebrand, K A, Patterson, S D, King, G J

“…The elbow is the second most common joint dislocated in adults. Up to 20% of dislocations are associated with fractures. Treatment principles are reduction of…”
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Proteomics: the first decade and beyond by Patterson, Scott D, Aebersold, Ruedi H

“…Proteomics is the systematic study of the many and diverse properties of proteins in a parallel manner with the aim of providing detailed descriptions of the…”
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Characterization of individual nanomagnets by the local Hall effect by Monzon, F.G., Patterson, D.S., Roukes, M.L.

“…We describe a straightforward approach to the characterization of individual thin-film NiFe ferromagnets, useful from cryogenic to room temperature. The…”
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Distal biceps brachii tendon repair: An in vitro biomechanical study of tendon reattachment by BERLET, G. C, JOHNSON, J. A, MILNE, A. D, PATTERSON, S. D, KING, G. J. W

“…Clinical reports suggest that suture anchors can simplify repair of distal biceps tendon avulsions. In this study, fixation strengths of Mitek and Statak…”
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Case studies, practical issues and observations on population and individual bioequivalence by Zariffa, Névine M.-D., Patterson, S. D., Boyle, D., Hyneck, M.

“…The FDA has proposed replacing the 1992 average bioequivalence (ABE) with population and individual bioequivalence (PBE and IBE). This has led to considerable…”
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Determination of Disulfide Bonds in Highly Bridged Disulfide-Linked Peptides by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Postsource Decay by Jones, Michael D, Patterson, Scott D, Lu, Hsieng S

“…Matrix-assisted laser desorption/ionization mass spectrometry with postsource decay was used to generate fragment ions from peptide fragments containing…”
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PhRMA Perspective on Population and Individual Bioequivalence by Barrett, Jeffrey S., Batra, Vijay, Chow, Andrew, Cook, Jack, Gould, A. Lawrence, Heller, Allen H., Lo, Man-Wai, Patterson, Scott D., Smith, Brian P., Stritar, Jeffrey A., Vega, Jose M., Zariffa, Névine

“…The Food and Drug Administration (FDA) issued a second‐draft guidance in August 1999 on the subject of in vivo bioequivalence, which is based on the concepts…”
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NASA's Satellite Laser Ranging Systems for the 21st Century by Mcgarry, J. F., Hoffman, E. D., Degnan, J. J., Cheek, J. W., Clarke, C. B., Diegel, I. F., Donovan, H. L., Horvath, J. E., Marzouk, M., Nelson, A. R., Patterson, D. S., Ricklefs, R. L., Shappirio, M. D., Wetzel, S. L., Zagwodzki, T. W.

“…For over 40 years, NASA’s global network of satellite laser ranging (SLR) stations has provided a significant percentage of the global orbital data used to…”
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Urinary excretion of 6β-hydroxycortisol as an in vivo marker for CYP3A induction: Applications and recommendations by Kovacs, Steven J., Martin, David E., Everitt, Daniel E., Patterson, Scott D., Jorkasky, Diane K.

“…Objective To evaluate the usefulness of 6β‐hydroxycortisol as a screen for CYP3A induction in early‐phase drug development. Methods Five groups of 12 healthy…”
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Lack of Effect of Rosiglitazone on the Pharmacokinetics of Oral Contraceptives in Healthy Female Volunteers by Inglis, Anne Marie L., Miller, Ann K., Culkin, Kathleen Thompson, Finnerty, Dana, Patterson, Scott D., Jorkasky, Diane K., Freed, Martin I.

“…The effect of rosiglitazone (Avandia® [BRL 49653C]) on the pharmacokinetics of ethinylestmdiol and norethindrone was evaluated after repeat dosing of…”
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Non-traditional study designs to demonstrate average bioequivalence for highly variable drug products by PATTERSON, Scott D, ZARIFFA, Névine M.-D, MONTAGUE, Timothy H, HOWLAND, Kate

“…To demonstrate average bioequivalence, the ninety-percent confidence intervals (CI) on the ratio of geometric means for area under the concentration-time curve…”
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