Search Results - "Patterson, L Jean"

Prototype Pathogens for Vaccine and Monoclonal Antibody Countermeasure Development: NIAID Workshop Process and Outcomes for Viral Families of Pandemic Potential by Deschamps, Anne M, DeRocco, Amanda J, Bok, Karin, Patterson, L Jean

“…Abstract Given the increased risk of pandemics driven by emerging and reemerging infectious diseases, it is imperative that the United States and global…”
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Directional entry and release of Zika virus from polarized epithelial cells by Tamhankar, Manasi, Patterson, Jean L

“…Both vector borne and sexual transmission of Zika virus (ZIKV) involve infection of epithelial cells in the initial stages of infection. Epithelial cells are…”
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Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques by Xiao, Peng, Zhao, Jun, Patterson, L. Jean, Brocca-Cofano, Egidio, Venzon, David, Kozlowski, Pamela A., Hidajat, Rachmat, Demberg, Thorsten, Robert-Guroff, Marjorie

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A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates by Callendret, Benoit, Vellinga, Jort, Wunderlich, Kerstin, Rodriguez, Ariane, Steigerwald, Robin, Dirmeier, Ulrike, Cheminay, Cedric, Volkmann, Ariane, Brasel, Trevor, Carrion, Ricardo, Giavedoni, Luis D, Patterson, Jean L, Mire, Chad E, Geisbert, Thomas W, Hooper, Jay W, Weijtens, Mo, Hartkoorn-Pasma, Jutta, Custers, Jerome, Grazia Pau, Maria, Schuitemaker, Hanneke, Zahn, Roland

“…The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal…”
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Author Correction: Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge by Liu, Ying, Ye, Ling, Lin, Fang, Gomaa, Yasmine, Flyer, David, Carrion, Ricardo, Patterson, Jean L., Prausnitz, Mark R., Smith, Gale, Glenn, Gregory, Wu, Hua, Compans, Richard W., Yang, Chinglai

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Optofluidic Amplification-Free Multiplex Detection of Viral Hemorrhagic Fevers by Stambaugh, Alexandra M., Stott, Matthew A., Meena, Gopikrishnan G., Tamhankar, Manasi, Carrion, Ricardo, Patterson, Jean L., Hawkins, Aaron R., Schmidt, Holger

“…Infectious disease outbreaks such as Ebola and other Viral Hemorrhagic Fevers (VHF) require low-complexity, specific, and differentiated diagnostics as…”
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Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells by Tamhankar, Manasi, Gerhardt, Dawn M, Bennett, Richard S, Murphy, Nicole, Jahrling, Peter B, Patterson, Jean L

“…Currently, no FDA-approved vaccines or treatments are available for Ebola virus disease (EVD), and therapy remains largely supportive. Ebola virus (EBOV) has…”
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Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques by Alfson, Kendra J, Avena, Laura E, Beadles, Michael W, Staples, Hilary, Nunneley, Jerritt W, Ticer, Anysha, Dick, Jr, Edward J, Owston, Michael A, Reed, Christopher, Patterson, Jean L, Carrion, Jr, Ricardo, Griffiths, Anthony

“…This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense…”
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Filoviruses Utilize Glycosaminoglycans for Their Attachment to Target Cells by Salvador, Beatriz, Sexton, Nicole R, Carrion, Jr, Ricardo, Nunneley, Jerritt, Patterson, Jean L, Steffen, Imke, Lu, Kai, Muench, Marcus O, Lembo, David, Simmons, Graham

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Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Recombinant Priming and Envelope Protein Boosting Elicits Localized, Mucosal IgA Immunity in Rhesus Macaques Correlated with Delayed Acquisition following a Repeated Low-Dose Rectal SIVmac251 Challenge by PENG XIAO, JEAN PATTERSON, L, KALISZ, Irene, KALYANARAMAN, Vaniambadi S, PAL, Ranajit, MONTEFIORI, David, KEELE, Brandon F, ROBERT-GUROFF, Marjorie, KUATE, Seraphin, BROCCA-COFANO, Egidio, THOMAS, Michael A, VENZON, David, JUN ZHAO, DIPASQUALE, Janet, FENIZIA, Claudio, MI LEE, Eun

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Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013 by Bukreyev, Alexander A, Chandran, Kartik, Dolnik, Olga, Dye, John M, Ebihara, Hideki, Leroy, Eric M, Mühlberger, Elke, Netesov, Sergey V, Patterson, Jean L, Paweska, Janusz T, Saphire, Erica Ollmann, Smither, Sophie J, Takada, Ayato, Towner, Jonathan S, Volchkov, Viktor E, Warren, Travis K, Kuhn, Jens H

“…The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group prepares proposals on the classification and nomenclature of filoviruses to…”
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Rapid detection and quantification of Ebola Zaire virus by one‐step real‐time quantitative reverse transcription‐polymerase chain reaction by Ro, Young‐Tae, Ticer, Anysha, Carrion, Ricardo, Patterson, Jean L.

“…ABSTRACT Given that Ebola virus causes severe hemorrhagic fever in humans with mortality rates as high as 90%, rapid and accurate detection of this virus is…”
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Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice by Li, Wenfang, Ye, Ling, Carrion, Ricardo, Mohan, Gopi S., Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L., Compans, Richard W., Yang, Chinglai

“…In addition to its surface glycoprotein (GP), Ebola virus directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted…”
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Molecular Approaches for the Validation of the Baboon as a Nonhuman Primate Model for the Study of Zika Virus Infection by Mask, Emma, Hodara, Vida L, Callery, Jessica E, Parodi, Laura M, Obregon-Perko, Veronica, Yagi, Shigeo, Glenn, Jeremy, Frost, Patrice, Clemmons, Elizabeth, Patterson, Jean L, Cox, Laura A, Giavedoni, Luis D

“…Nonhuman primates (NHP) are particularly important for modeling infections with viruses that do not naturally replicate in rodent cells. Zika virus (ZIKV) has…”
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Intramuscular Exposure of Macaca fascicularis to Low Doses of Low Passage- or Cell Culture-Adapted Sudan Virus or Ebola Virus by Alfson, Kendra J, Avena, Laura E, Beadles, Michael W, Worwa, Gabriella, Amen, Melanie, Patterson, Jean L, Carrion, Jr, Ricardo, Griffiths, Anthony

“…The filoviruses Ebola virus (EBOV) and Sudan virus (SUDV) can cause severe diseases, and there are currently no licensed countermeasures available for use…”
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Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection by Liu, Ying, Wen, Zhiyuan, Carrion, Jr, Ricardo, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L, Compans, Richard W, Ye, Ling, Yang, Chinglai

“…Ebolavirus (EBOV) infection in humans causes severe hemorrhagic fevers with high mortality rates that range from 30 to 80% as shown in different outbreaks…”
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Ebola Virus Does Not Block Apoptotic Signaling Pathways by Olejnik, Judith, Alonso, Jesus, Schmidt, Kristina M, Yan, Zhen, Wang, Wei, Marzi, Andrea, Ebihara, Hideki, Yang, Jinghua, Patterson, Jean L, Ryabchikova, Elena, Mühlberger, Elke

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A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity by Gómez-Román, V. Raúl, Florese, Ruth H., Patterson, L. Jean, Peng, Bo, Venzon, David, Aldrich, Kris, Robert-Guroff, Marjorie

“…We demonstrate that the FATAL cytolysis assay can be adapted into a rapid and fluorometric antibody-dependent cellular cytotoxicity assay (RFADCC). The RFADCC…”
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A novel adenovirus species associated with an acute respiratory outbreak in a baboon colony and evidence of coincident human infection by Chiu, Charles Y, Yagi, Shigeo, Lu, Xiaoyan, Yu, Guixia, Chen, Eunice C, Liu, Maria, Dick, Jr, Edward J, Carey, Kenneth D, Erdman, Dean D, Leland, Michelle M, Patterson, Jean L

“…Adenoviruses (AdVs) are DNA viruses that infect many vertebrate hosts, including humans and nonhuman primates. Here we identify a novel AdV species,…”
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Protection against lethal challenge by Ebola virus-like particles produced in insect cells by Sun, Yuliang, Carrion, Ricardo, Ye, Ling, Wen, Zhiyuan, Ro, Young-Tae, Brasky, Kathleen, Ticer, Anysha E, Schwegler, E. Ellen, Patterson, Jean L, Compans, Richard W, Yang, Chinglai

“…Abstract Ebola virus-like particles (VLPs) were produced in insect cells using a recombinant baculovirus expression system and their efficacy for protection…”
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