Search Results - "Patterson, Joseph R"

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology by Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Gezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O'Mara, Alana, Yonkers, Reid, Kordower, Jeffrey H.

“…Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic…”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions by Stoll, Anna C., Kemp, Christopher J., Patterson, Joseph R., Howe, Jacob W., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E., Benskey, Matthew J.

“…Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars…”
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition by Stoll, Anna C, Kemp, Christopher J, Patterson, Joseph R, Kubik, Michael, Kuhn, Nathan, Benskey, Matthew, Duffy, Megan F, Luk, Kelvin C, Sortwell, Caryl E

“…Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy…”
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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits by Gezer, Aysegul O., Kochmanski, Joseph, VanOeveren, Sarah E., Cole-Strauss, Allyson, Kemp, Christopher J., Patterson, Joseph R., Miller, Kathryn M., Kuhn, Nathan C., Herman, Danielle E., McIntire, Alyssa, Lipton, Jack W., Luk, Kelvin C., Fleming, Sheila M., Sortwell, Caryl E., Bernstein, Alison I.

“…Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD)…”
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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Fischer, D Luke, Stoll, Anna C, Sortwell, Caryl E

“…Animal models have significantly advanced our understanding of Parkinson's disease (PD). Alpha-synuclein (α-syn) has taken center stage due to its genetic…”
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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils by Patterson, Joseph R., Kochmanski, Joseph, Stoll, Anna C., Kubik, Michael, Kemp, Christopher J., Duffy, Megan F., Thompson, Kajene, Howe, Jacob W., Cole-Strauss, Allyson, Kuhn, Nathan C., Miller, Kathryn M., Nelson, Seth, Onyekpe, Christopher U., Beck, John S., Counts, Scott E., Bernstein, Alison I., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E.

“…Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease…”
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Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein by Patterson, Joseph R., Hirst, Warren D., Howe, Jacob W., Russell, Christopher P., Cole-Strauss, Allyson, Kemp, Christopher J., Duffy, Megan F., Lamp, Jared, Umstead, Andrew, Kubik, Michael, Stoll, Anna C., Vega, Irving E., Steece-Collier, Kathy, Chen, Yi, Campbell, Anne C., Nezich, Catherine L., Glajch, Kelly E., Sortwell, Caryl E.

“…β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression…”
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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats…”
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Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain by Kochmanski, Joseph, VanOeveren, Sarah E, Patterson, Joseph R, Bernstein, Alison I

“…Abstract Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson’s disease…”
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Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS by Miller, Kathryn M, Patterson, Joseph R, Kochmanski, Joseph, Kemp, Christopher J, Stoll, Anna C, Onyekpe, Christopher U, Cole-Strauss, Allyson, Steece-Collier, Kathy, Howe, Jacob W, Luk, Kelvin C, Sortwell, Caryl E

“…Preclinical studies show a link between subthalamic nucleus (STN) deep brain stimulation (DBS) and neuroprotection of nigrostriatal dopamine (DA) neurons,…”
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Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice by Boyd, Sierra L, Kuhn, Nathan C, Patterson, Joseph R, Stoll, Anna C, Zimmerman, Sydney A, Kolanowski, Mason R, Neubecker, Joseph J, Luk, Kelvin C, Ramsson, Eric S, Sortwell, Caryl E, Bernstein, Alison I

“…Abstract Parkinson’s disease (PD) is the fastest-growing neurological disease worldwide, with increases outpacing aging and occurring most rapidly in recently…”
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Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease by Sossi, Vesna, Patterson, Joseph R., McCormick, Siobhan, Kemp, Christopher J., Miller, Kathryn M., Stoll, Anna C., Kuhn, Nathan, Kubik, Michael, Kochmanski, Joseph, Luk, Kelvin C., Sortwell, Caryl E.

“…Background Positron emission tomography (PET) imaging in early Parkinson's disease (PD) subjects reveals that increased dopamine (DA) turnover and reduced…”
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Deficits in basal and evoked striatal dopamine release following alpha‐synuclein preformed fibril injection: An in vivo microdialysis study by Centner, Ashley, Del Priore, Isabella, Chambers, Nicole, Cohen, Sophie R., Terry, Michelle L., Coyle, Michael, Glinski, John, Stoll, Anna C., Patterson, Joseph R., Kemp, Christopher J., Miller, Kathryn M., Kubik, Michael, Kuhn, Nathan, Luk, Kelvin C., Sortwell, Caryl E., Bishop, Christopher

“…Parkinson's disease (PD) is characterized by the accumulation of misfolded alpha‐synuclein (α‐syn) protein, forming intraneuronal Lewy body (LB) inclusions…”
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Remodeling of the endoplasmic reticulum in Caenorhabditis elegans oocytes is regulated by CGH‐1 by Langerak, Shaughna, Trombley, Alicia, Patterson, Joseph R., Leroux, Devon, Couch, Alexandra, Wood, Megan P., Schisa, Jennifer A.

“…Summary A key aspect of development in all metazoans is remodeling at the cellular level. During the development of gametes, remodeling occurs throughout the…”
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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo by Patterson, Joseph R, Polinski, Nicole K, Duffy, Megan F, Kemp, Christopher J, Luk, Kelvin C, Volpicelli-Daley, Laura A, Kanaan, Nicholas M, Sortwell, Caryl E

“…Use of the in vivo alpha-synuclein preformed fibril (α-syn PFF) model of synucleinopathy is gaining popularity among researchers aiming to model Parkinson's…”
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Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein by Howe, Jacob W., Sortwell, Caryl E., Duffy, Megan F., Kemp, Christopher J., Russell, Christopher P., Kubik, Michael, Patel, Pooja, Luk, Kelvin C., El-Agnaf, Omar M.A., Patterson, Joseph R.

“…Alpha-synuclein (α-syn) preformed fibril (PFF)-induced pathology can be used to study the features and progression of synucleinopathies, such as Parkinson's…”
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FosB and ΔFosB expression in brain regions containing differentially susceptible dopamine neurons following acute neurotoxicant exposure by Patterson, Joseph R, Kim, Elizabeth J, Goudreau, John L, Lookingland, Keith J

“…Abstract Parkinson disease (PD) is characterized by progressive neuronal degeneration, in particular nigrostriatal dopamine (NSDA) neurons and consequent…”
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Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing by Patterson, Joseph R., Wood, Megan P., Schisa, Jennifer A.

“…Protective cellular responses to stress and aging in the germline are essential for perpetuation of a species; however, relatively few studies have focused on…”
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