The value of the bone scan and bone marrow biopsy staging small cell lung cancer

The value of the bone scan and bone marrow biopsy staging small cell lung cancer

The charts of 112 patients with small cell lung cancer were reviewed in a retrospective fashion in order to define the role of the radionuclide bone scan and bone marrow biopsy in the staging of this disease. Both a radionuclide bone scan and bone marrow biopsy were performed on all patients at the...

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Bibliographic Details
Published in:Cancer Vol. 56; no. 3; p. 652
Main Authors: Levitan, N, Byrne, R E, Bromer, R H, Faling, L J, Caslowitz, P, Pattern, D H, Hong, W K
Format: Journal Article
Language:English
Published: United States 01-08-1985
Subjects:
Biopsy
Bone and Bones - diagnostic imaging
Bone Marrow - pathology
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - pathology
Bone Neoplasms - secondary
Carcinoma, Small Cell - diagnostic imaging
Carcinoma, Small Cell - pathology
Carcinoma, Small Cell - secondary
Humans
Lung - pathology
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Neoplasm Staging
Prognosis
Radionuclide Imaging
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Summary:The charts of 112 patients with small cell lung cancer were reviewed in a retrospective fashion in order to define the role of the radionuclide bone scan and bone marrow biopsy in the staging of this disease. Both a radionuclide bone scan and bone marrow biopsy were performed on all patients at the time of diagnosis. Sixty-one percent of patients had a negative bone scan and negative biopsy; 22% had a positive bone scan and negative biopsy; 8% had a negative scan and positive biopsy; and 9% had a positive scan and positive biopsy. In 21 of the 44 patients with osseous involvement, no other focus of distant metastasis was found. The bone scan showed greater than or equal to 3 areas of increased uptake in 15 patients, 2 areas of increased uptake in 13 patients, and 1 area in 7 patients. The number of patients with bone marrow biopsy results positive for tumor in these 3 groups were 5, 3, and 2, respectively. Our study shows a lack of correlation between bone scan and bone marrow biopsy results. The bone scan and bone marrow biopsy identify independent patterns of osseous metastasis. Both procedures should be performed in the evaluation of patients with small cell lung cancer.
ISSN:0008-543X
DOI:10.1002/1097-0142(19850801)56:3<652::AID-CNCR2820560336>3.0.CO;2-G