Search Results - "Patten, Scott M. Van"

Glycan Structure Determinants for Cation-Independent Mannose 6‑Phosphate Receptor Binding and Cellular Uptake of a Recombinant Protein by Zhou, Qun, Avila, Luis Z, Konowicz, Paul A, Harrahy, John, Finn, Patrick, Kim, Jennifer, Reardon, Michael R, Kyazike, Josephine, Brunyak, Elizabeth, Zheng, Xiaoyang, Patten, Scott M. Van, Miller, Robert J, Pan, Clark Q

“…The cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in intracellular transport of lysosomal enzymes as well as the uptake of…”
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Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease by Van Patten, Scott M, Hughes, Heather, Huff, Michael R, Piepenhagen, Peter A, Waire, James, Qiu, Huawei, Ganesa, Chandrashekar, Reczek, David, Ward, Paul V, Kutzko, Joseph P, Edmunds, Tim

“…Recombinant human glucocerebrosidase (imiglucerase, Cerezyme®) is used in enzyme replacement therapy for Gaucher disease. Complex oligosaccharides present on…”
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Activation of Human Acid Sphingomyelinase through Modification or Deletion of C-terminal Cysteine by Qiu, Huawei, Edmunds, Tim, Baker-Malcolm, Jennifer, Karey, Kenneth P., Estes, Scott, Schwarz, Cordula, Hughes, Heather, Van Patten, Scott M.

“…One form of Niemann-Pick disease is caused by a deficiency in the enzymatic activity of acid sphingomyelinase. During efforts to develop an enzyme replacement…”
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Production of recombinant albumin by a herd of cloned transgenic cattle by Echelard, Yann, Williams, Jennifer L, Destrempes, Margaret M, Koster, Julie A, Overton, Susan A, Pollock, Daniel P, Rapiejko, Karen T, Behboodi, Esmail, Masiello, Nicholas C, Gavin, William G, Pommer, Jerry, Van Patten, Scott M, Faber, David C, Cibelli, Jose B, Meade, Harry M

“…Purified plasma derived human albumin has been available as a therapeutic product since World War II. However, cost effective recombinant production of albumin…”
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X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase by Wei, Ronnie R., Hughes, Heather, Boucher, Susan, Bird, Julie J., Guziewicz, Nicholas, Van Patten, Scott M., Qiu, Huawei, Pan, Clark Qun, Edmunds, Tim

“…Gaucher disease is caused by mutations in the enzyme acid β-glucosidase (GCase), the most common of which is the substitution of serine for asparagine at…”
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Strategies for Neoglycan Conjugation to Human Acid α-Glucosidase by Zhou, Qun, Stefano, James E, Harrahy, John, Finn, Patrick, Avila, Luis, Kyazike, Josephine, Wei, Ronnie, Van Patten, Scott M, Gotschall, Russell, Zheng, Xiaoyang, Zhu, Yunxiang, Edmunds, Tim, Pan, Clark Q

“…Engineering proteins for selective tissue targeting can improve therapeutic efficacy and reduce undesired side effects. The relatively high dose of recombinant…”
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Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma–Derived Antithrombin by Edmunds, Tim, Van Patten, Scott M., Pollock, Julie, Hanson, Eric, Bernasconi, Richard, Higgins, Elizabeth, Manavalan, Partha, Ziomek, Carol, Meade, Harry, McPherson, John M., Cole, Edward S.

“…Recombinant human antithrombin (rhAT) produced in transgenic goat milk was purified to greater than 99%. The specific activity of the rhAT was identical to…”
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Oxidation of Methionine Residues in Antithrombin by Van Patten, Scott M., Hanson, Eric, Bernasconi, Richard, Zhang, Kate, Manavalan, Partha, Cole, Edward S., McPherson, John M., Edmunds, Tim

“…Commercially available human plasma-derived preparations of the serine protease inhibitor antithrombin (AT) were shown to contain low levels of oxidation, and…”
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Strategies for Neoglycan Conjugation to Human Acid [alpha]-Glucosidase by Zhou, Qun, Stefano, James E, Harrahy, John, Finn, Patrick, Avila, Luis, Kyazike, Josephine, Wei, Ronnie, Van Patten, Scott M, Gotschall, Russell, Zheng, Xiaoyang, Zhu, Yunxiang, Edmunds, Tim, Pan, Clark Q

“…Engineering proteins for selective tissue targeting can improve therapeutic efficacy and reduce undesired side effects. The relatively high dose of recombinant…”
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Oxidation of methionine residues in antithrombin. Effects on biological activity and heparin binding by Van Patten, S M, Hanson, E, Bernasconi, R, Zhang, K, Manavalan, P, Cole, E S, McPherson, J M, Edmunds, T

“…Commercially available human plasma-derived preparations of the serine protease inhibitor antithrombin (AT) were shown to contain low levels of oxidation, and…”
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Multiplicity of the β Form of the cAMP-dependent Protein Kinase Inhibitor Protein Generated by Post-translational Modification and Alternate Translational Initiation by Priyadarsini Kumar, Scott M. Van Patten, Donal A. Walsh

“…Two distinct species of the thermostable inhibitor of the cAMP-dependent protein kinase, PKIα and PKIβ, exist that are the products of separate genes. The…”
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Multiplicity of the β Form of the cAMP-dependent Protein Kinase Inhibitor Protein Generated by Post-translational Modification and Alternate Translational Initiation by Kumar, Priyadarsini, Van Patten, Scott M., Walsh, Donal A.

“…Two distinct species of the thermostable inhibitor of the cAMP-dependent protein kinase, PKIα and PKIβ, exist that are the products of separate genes. The PKIβ…”
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The alpha- and beta-isoforms of the inhibitor protein of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase: characteristics and tissue- and developmental-specific expression by Van Patten, S M, Howard, P, Walsh, D A, Maurer, R A

“…The inhibitor protein (PKI) of the cAMP-dependent protein kinase was first characterized from rabbit skeletal muscle. More recently a form of PKI was isolated…”
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Specific Testicular Cellular Localization and Hormonal Regulation of the PKIα and PKIβ Isoforms of the Inhibitor Protein of the cAMP-dependent Protein Kinase by Scott M. Van Patten, Lucy F. Donaldson, Michael P. McGuinness, Priyadarsini Kumar, Azita Alizadeh, Michael D. Griswold, Donal A. Walsh

“…We have previously demonstrated that there exist two distinct genes for the thermostable inhibitor protein of the cAMP-dependent protein kinase, PKIα and…”
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Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma–Derived Antithrombin by Edmunds, Tim, Van Patten, Scott M., Pollock, Julie, Hanson, Eric, Bernasconi, Richard, Higgins, Elizabeth, Manavalan, Partha, Ziomek, Carol, Meade, Harry, McPherson, John M., Cole, Edward S.

“…Recombinant human antithrombin (rhAT) produced in transgenic goat milk was purified to greater than 99%. The specific activity of the rhAT was identical to…”
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Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase by Toner-Webb, J, van Patten, S M, Walsh, D A, Taylor, S S

“…The catalytic subunit of cAMP-dependent protein kinase contains two stable phosphorylation sites, Thr-197 and Ser-338 (Shoji, S., Titani, K., Demaille, J. G.,…”
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Specific Testicular Cellular Localization and Hormonal Regulation of the PKIα and PKIβ Isoforms of the Inhibitor Protein of the cAMP-dependent Protein Kinase by Van Patten, Scott M., Donaldson, Lucy F., McGuinness, Michael P., Kumar, Priyadarsini, Alizadeh, Azita, Griswold, Michael D., Walsh, Donal A.

“…We have previously demonstrated that there exist two distinct genes for the thermostable inhibitor protein of the cAMP-dependent protein kinase, PKIα and PKIβ…”
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Molecular Cloning of a Rat Testis form of the Inhibitor Protein of cAMP- Dependent Protein Kinase by Van Patten, Scott M., Ng, Dean C., John P. H. Th'ng, Angelos, Karen L., Smith, Alan J., Walsh, Donal A.

“…The form of inhibitor protein of the cAMP-dependent protein kinase (PKI) that has been most thoroughly studied is a protein purified from rabbit skeletal…”
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Expression in Escherichia coli and characterization of the heat-stable inhibitor of the cAMP-dependent protein kinase by THOMAS, J, VAN PATTEN, S. M, HOWARD, P, DAY, K. H, MITCHELL, R. D, SOSNICK, T, TREWHELLA, J, WALSH, D. A, MAURER, R. A

“…Pure heat-stable inhibitor of the cAMP-dependent protein kinase (PKI) has been isolated in high yield by using a bacterial expression vector constructed to…”
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Motifs of protein phosphorylation and mechanisms of reversible covalent regulation by Walsh, D A, Newsholme, P, Cawley, K C, van Patten, S M, Angelos, K L

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