Search Results - "Patsoukis, Nikolaos"

Revisiting the PD-1 pathway by Patsoukis, Nikolaos, Wang, Qi, Strauss, Laura, Boussiotis, Vassiliki A

“…Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells. PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral…”
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PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2 by Patsoukis, Nikolaos, Li, Lequn, Sari, Duygu, Petkova, Victoria, Boussiotis, Vassiliki A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeted deletion of PD-1 in myeloid cells induces antitumor immunity by Strauss, Laura, Mahmoud, Mohamed A A, Weaver, Jessica D, Tijaro-Ovalle, Natalia M, Christofides, Anthos, Wang, Qi, Pal, Rinku, Yuan, Min, Asara, John, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…PD-1, a T cell checkpoint receptor and target of cancer immunotherapy, is also expressed on myeloid cells. The role of myeloid-specific versus T cell-specific…”
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Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy by Le Bourgeois, Thibault, Strauss, Laura, Aksoylar, Halil-Ibrahim, Daneshmandi, Saeed, Seth, Pankaj, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…There has been significant progress in utilizing our immune system against cancer, mainly by checkpoint blockade and T cell-mediated therapies. The field of…”
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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation by Patsoukis, Nikolaos, Duke-Cohan, Jonathan S., Chaudhri, Apoorvi, Aksoylar, Halil-Ibrahim, Wang, Qi, Council, Asia, Berg, Anders, Freeman, Gordon J., Boussiotis, Vassiliki A.

“…Programmed cell death-1 (PD-1) inhibits T cell responses. This function relies on interaction with SHP-2. PD-1 has one immunoreceptor tyrosine-based inhibitory…”
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The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression by Patsoukis, Nikolaos, Bardhan, Kankana, Weaver, Jessica D, Sari, Duygu, Torres-Gomez, Alvaro, Li, Lequn, Strauss, Laura, Lafuente, Esther M, Boussiotis, Vassiliki A

“…Lymphocyte activation requires adhesion to antigen-presenting cells. This is a critical event linking innate and adaptive immunity. Lymphocyte adhesion is…”
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Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells by Li, Lequn, Patsoukis, Nikolaos, Petkova, Victoria, Boussiotis, Vassiliki A

“…CD4(+)Foxp3(+) T regulatory cells (Tregs) display phenotypic and functional plasticity that is regulated by cytokines and other immune cells. Previously, we…”
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Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress by Georgiou, Christos D., Patsoukis, Nikolaos, Papapostolou, Ioannis, Zervoudakis, George

“…Sclerotium-forming filamentous fungi are of great agricultural and biological interest because they can be viewed as models of simple metamorphosis. They…”
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Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging by Grintzalis, Konstantinos, Patsoukis, Nikolaos, Papapostolou, Ioannis, Zervoudakis, George, Kalaitzopoulou, Electra, Georgiou, Christos D., Matsokis, Nikolaos A., Panagopoulos, Nikolaos T.

“…•Oxidative damage leads to the aging-related dysfunction in mouse brain.•Identification of oxidative stress (OS) markers of thiol redox status is crucial in…”
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Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM) by Sari-Ak, Duygu, Torres-Gomez, Alvaro, Yazicioglu, Yavuz-Furkan, Christofides, Anthos, Patsoukis, Nikolaos, Lafuente, Esther M, Boussiotis, Vassiliki A

“…Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during…”
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Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure by Patsoukis, Nikolaos, Zervoudakis, George, Panagopoulos, Nikolaos T, Georgiou, Christos D, Angelatou, Fevronia, Matsokis, Nikolaos A

“…In this study we evaluated oxidative stress (lipid peroxidation and protein oxidation) and thiol redox state [TRS: glutathione (GSH), glutathione disulfide…”
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Thiol Redox State and Lipid and Protein Oxidation in the Mouse Striatum after Pentylenetetrazol‐induced Epileptic Seizure by Patsoukis, Nikolaos, Zervoudakis, George, Georgiou, Christos D., Angelatou, Fevronia, Matsokis, Nikolaos A., Panagopoulos, Nikolaos T.

“…Purpose: In the present study, we examined the effects of pentylenetetrazol (PTZ) administration on the thiol redox state (TRS), lipid peroxidation, and…”
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Effect of Antioxidant Treatments on the Gut–Liver Axis Oxidative Status and Function in Bile Duct‐Ligated Rats by Assimakopoulos, Stelios F., Maroulis, Ioannis, Patsoukis, Nikolaos, Vagenas, Konstantinos, Scopa, Chrisoula D., Georgiou, Christos D., Vagianos, Constantine E.

“…Background Experimental and clinical studies have demonstrated the pivotal role of oxidative stress in the promotion of hepatic and intestinal injury in…”
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Brain Oxidative Stress Induced by Obstructive Jaundice in Rats by Chroni, Elisabeth, Patsoukis, Nikolaos, Karageorgos, Nikolaos, Konstantinou, Dimitris, Georgiou, Christos

“…The effect of experimental obstructive jaundice on the oxidative status of brain tissues in rats was examined. Twenty-four male Wistar rats were divided into 4…”
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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation by Patsoukis, Nikolaos, Brown, Julia, Petkova, Victoria, Liu, Fang, Li, Lequn, Boussiotis, Vassiliki A

“…The receptor programmed death 1 (PD-1) inhibits T cell proliferation and plays a critical role in suppressing self-reactive T cells, and it also compromises…”
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Targeted Deletion of Pparβ/δ in Myeloid Cells Enhances Their Tumor-Promoting Function by Christofides, Anthos, Pal, Rinku, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…Peroxisome proliferator activated receptors (PPARs) are transcription factors of the nuclear hormone transcription superfamily. Thee different PPAR subtypes…”
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PTEN checkMAITs type-17 innate-like T cells by Patsoukis, Nikolaos, Boussiotis, Vassiliki A.

“…PTEN, a tumour suppressor, also regulates T cell activation. A new study reports that PTEN acts as a cell-intrinsic rheostat linking TCR- and IL-23-mediated…”
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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation by Patsoukis, Nikolaos, Bardhan, Kankana, Chatterjee, Pranam, Sari, Duygu, Liu, Bianling, Bell, Lauren N., Karoly, Edward D., Freeman, Gordon J., Petkova, Victoria, Seth, Pankaj, Li, Lequn, Boussiotis, Vassiliki A.

“…During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells…”
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Translational Fidelity Mutations in 18S rRNA Affect the Catalytic Activity of Ribosomes and the Oxidative Balance of Yeast Cells by Konstantinidis, Theodoros C, Patsoukis, Nikolaos, Georgiou, Christos D, Synetos, Dennis

“…The function of mutations rdn1A, rdn1T, and rdn2 in 18S rRNA of Saccharomyces cerevisiae is investigated. The mutations correspond to substitutions C1054A,…”
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PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A by Patsoukis, Nikolaos, Sari, Duygu, Boussiotis, Vassiliki A.

“…The programmed cell death-1 (PD)-1 receptor (CD279) is a potent T cell inhibitor with a critical role in peripheral tolerance, but it can also compromise…”
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