Search Results - "Patsopoulos, A"

Genetics of Multiple Sclerosis: An Overview and New Directions by Patsopoulos, Nikolaos A

“…The contribution of genetic inheritance in multiple sclerosis was established early on. Although multiple sclerosis is not a Mendelian disease, its incidence…”
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Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types by Chun, Sung, Casparino, Alexandra, Patsopoulos, Nikolaos A, Croteau-Chonka, Damien C, Raby, Benjamin A, De Jager, Philip L, Sunyaev, Shamil R, Cotsapas, Chris

“…Shamil Sunyaev, Chris Cotsapas and colleagues present a joint likelihood framework for determining the statistical evidence of shared genetic effects of…”
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Genetic and epigenetic fine mapping of causal autoimmune disease variants by Farh, Kyle Kai-How, Marson, Alexander, Zhu, Jiang, Kleinewietfeld, Markus, Housley, William J., Beik, Samantha, Shoresh, Noam, Whitton, Holly, Ryan, Russell J. H., Shishkin, Alexander A., Hatan, Meital, Carrasco-Alfonso, Marlene J., Mayer, Dita, Luckey, C. John, Patsopoulos, Nikolaos A., De Jager, Philip L., Kuchroo, Vijay K., Epstein, Charles B., Daly, Mark J., Hafler, David A., Bernstein, Bradley E.

“…Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here…”
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Exchange bias effect in cylindrical nanowires with ferromagnetic core and polycrystalline antiferromagnetic shell by Patsopoulos, A., Kechrakos, D.

“…•Exchange bias in Co/CoO core-shell nanowires.•Effect of shell polycrystallinity on magnetization reversal.•Angular dependent exchange bias effect.•SW model…”
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Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects by Patsopoulos, Nikolaos A, Barcellos, Lisa F, Hintzen, Rogier Q, Schaefer, Catherine, van Duijn, Cornelia M, Noble, Janelle A, Raj, Towfique, Gourraud, Pierre-Antoine, Stranger, Barbara E, Oksenberg, Jorge, Olsson, Tomas, Taylor, Bruce V, Sawcer, Stephen, Hafler, David A, Carrington, Mary, De Jager, Philip L, de Bakker, Paul I W

“…The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect,…”
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Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes by Raj, Towfique, Rothamel, Katie, Mostafavi, Sara, Ye, Chun, Lee, Mark N., Replogle, Joseph M., Feng, Ting, Lee, Michelle, Asinovski, Natasha, Frohlich, Irene, Imboywa, Selina, Von Korff, Alina, Okada, Yukinori, Patsopoulos, Nikolaos A., Davis, Scott, McCabe, Cristin, Paik, Hyun-il, Srivastava, Gyan P., Raychaudhuri, Soumya, Hafler, David A., Koller, Daphne, Regev, Aviv, Hacohen, Nir, Mathis, Diane, Benoist, Christophe, Stranger, Barbara E., De Jager, Philip L.

“…To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of…”
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Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics by Chun, Sung, Imakaev, Maxim, Hui, Daniel, Patsopoulos, Nikolaos A., Neale, Benjamin M., Kathiresan, Sekar, Stitziel, Nathan O., Sunyaev, Shamil R.

“…In complex trait genetics, the ability to predict phenotype from genotype is the ultimate measure of our understanding of genetic architecture underlying the…”
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Magnetic properties of nanowires with ferromagnetic core and antiferromagnetic shell by Patsopoulos, A., Kechrakos, D., Moutis, N.

“…•Exchange bias in Co/CoO core-shell nanowires.•Shell granularity and magnetization reversal.•Critical diameter for transverse-to-vortex wall transition. We…”
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Heterogeneity in meta-analyses of genome-wide association investigations by Ioannidis, John P A, Patsopoulos, Nikolaos A, Evangelou, Evangelos

“…Meta-analysis is the systematic and quantitative synthesis of effect sizes and the exploration of their diversity across different studies. Meta-analyses are…”
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Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury by Izzy, Saef, Liu, Qiong, Fang, Zhou, Lule, Sevda, Wu, Limin, Chung, Joon Yong, Sarro-Schwartz, Aliyah, Brown-Whalen, Alexander, Perner, Caroline, Hickman, Suzanne E, Kaplan, David L, Patsopoulos, Nikolaos A, El Khoury, Joseph, Whalen, Michael J

“…The neuroinflammatory response to traumatic brain injury (TBI) is critical to both neurotoxicity and neuroprotection, and has been proposed as a potentially…”
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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets by Guo, Michael H, Sama, Prashanth, LaBarre, Brenna A, Lokhande, Hrishikesh, Balibalos, John, Chu, Ci, Du, Xiaomi, Kheradpour, Pouya, Kim, Charles C, Oniskey, Taylor, Snyder, Thomas, Soghoian, Damien Z, Weiner, Howard L, Chitnis, Tanuja, Patsopoulos, Nikolaos A

“…Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics…”
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Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population by Beecham, Ashley H, Amezcua, Lilyana, Chinea, Angel, Manrique, Clara P, Gomez, Lissette, Martinez, Andrea, Beecham, Gary W, Patsopoulos, Nikolaos A, Chitnis, Tanuja, Weiner, Howard L, De Jager, Philip L, Burchard, Esteban G, Lund, Brett T, Fitzgerald, Kathryn C, Calabresi, Peter A, Delgado, Silvia R, Oksenberg, Jorge R, McCauley, Jacob L

“…The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across…”
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The CYP24A1 gene variant rs2762943 is associated with low serum 1,25‐dihydroxyvitamin D levels in multiple sclerosis patients by Malhotra, Sunny, Midaglia, Luciana, Chuquisana, Omar, Patsopoulos, Nikolaos A., Ferrer, Roser, Giralt, Marina, Fissolo, Nicolas, Gil‐Varea, Elia, Triviño, Juan Carlos, Lünemann, Jan D., Montalban, Xavier, Comabella, Manuel

“…Background and purpose Vitamin D is considered to play a role in multiple sclerosis (MS) etiopathogenesis. A polymorphism in the CYP24A1 gene, rs2762943, was…”
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Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12 by Kurreeman, Fina A.S., Stahl, Eli A., Okada, Yukinori, Liao, Katherine, Diogo, Dorothée, Raychaudhuri, Soumya, Freudenberg, Jan, Kochi, Yuta, Patsopoulos, Nikolaos A., Gupta, Namrata, Sandor, Cynthia, Bang, So-Young, Lee, Hye-Soon, Padyukov, Leonid, Suzuki, Akari, Siminovitch, Kathy, Worthington, Jane, Gregersen, Peter K., Hughes, Laura B., Reynolds, Richard J., Bridges, S. Louis, Bae, Sang-Cheol, Yamamoto, Kazuhiko, Plenge, Robert M.

“…We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show…”
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Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans by Nakatsuka, Nathan, Patterson, Nick, Patsopoulos, Nikolaos A., Altemose, Nicolas, Tandon, Arti, Beecham, Ashley H., McCauley, Jacob L., Isobe, Noriko, Hauser, Stephen, De Jager, Philip L., Hafler, David A., Oksenberg, Jorge R., Reich, David

“…Epidemiological studies have suggested differences in the rate of multiple sclerosis (MS) in individuals of European ancestry compared to African ancestry,…”
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Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies by Brown, Brielin C, Price, Alkes L, Patsopoulos, Nikolaos A, Zaitlen, Noah

“…There is mounting evidence that complex human phenotypes are highly polygenic, with many loci harboring multiple causal variants, yet most genetic association…”
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A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity by Esposito, Federica, Sorosina, Melissa, Ottoboni, Linda, Lim, Elaine T., Replogle, Joseph M., Raj, Towfique, Brambilla, Paola, Liberatore, Giuseppe, Guaschino, Clara, Romeo, Marzia, Pertel, Thomas, Stankiewicz, James M., Martinelli, Vittorio, Rodegher, Mariaemma, Weiner, Howard L., Brassat, David, Benoist, Christophe, Patsopoulos, Nikolaos A., Comi, Giancarlo, Elyaman, Wassim, Martinelli Boneschi, Filippo, De Jager, Philip L.

“…Objective A proportion of multiple sclerosis (MS) patients experience disease activity despite treatment. The early identification of the most effective drug…”
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Characterization of CD41 + cells in the lymph node by Dai, Li, Uehara, Mayuko, Li, Xiaofei, LaBarre, Brenna A, Banouni, Naima, Ichimura, Takaharu, Lee-Sundlov, Melissa M, Kasinath, Vivek, Sullivan, Jade A, Ni, Heyu, Barone, Francesca, Giannini, Silvia, Bahmani, Baharak, Sage, Peter T, Patsopoulos, Nikolaos A, Tsokos, George C, Bromberg, Jonathan S, Hoffmeister, Karin, Jiang, Liwei, Abdi, Reza

“…Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment…”
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Relative Citation Impact of Various Study Designs in the Health Sciences by Patsopoulos, Nikolaos A, Analatos, Apostolos A, Ioannidis, John P. A

“…CONTEXT The relative merits of various study designs and their placement in hierarchies of evidence are often discussed. However, there is limited knowledge…”
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Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials by Valachis, A, Polyzos, N. P, Patsopoulos, N. Α, Georgoulias, V, Mavroudis, D, Mauri, D

“…Numerous studies have demonstrated that angiogenesis and in particular VEGF over-expression play an essential role in the progression and metastatic potential…”
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