Search Results - "Patrizia Somma, Maria"
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Nitric Oxide Prevents Glioblastoma Stem Cells' Expansion and Induces Temozolomide Sensitization
Published in International journal of molecular sciences (01-07-2023)“…Glioblastoma multiforme (GBM) has high mortality and recurrence rates. Malignancy resilience is ascribed to Glioblastoma Stem Cells (GSCs), which are resistant…”
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2
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Published in Nature communications (18-08-2014)“…Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy. Myc is causally implicated in…”
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3
Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation
Published in eLife (26-11-2018)“…Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether…”
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The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure
Published in PLoS genetics (15-05-2017)“…INT6/eIF3e is a highly conserved component of the translation initiation complex that interacts with both the 26S proteasome and the COP9 signalosome, two…”
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RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis
Published in PLoS genetics (17-09-2019)“…The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are…”
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The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly
Published in Cells (Basel, Switzerland) (01-03-2023)“…The ( ) gene was discovered about 40 years ago and shown to be required for both mitotic and meiotic cell division. Subsequent studies showed that is highly…”
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Correction to: DNA copy number evolution in Drosophila cell lines
Published in Genome Biology (11-03-2019)“…Following publication of the original article [1], the authors reported the following errors…”
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8
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors
Published in Cells (Basel, Switzerland) (26-06-2020)“…Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting…”
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Bypassing the Greatwall-Endosulfine pathway: plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans
Published in Genetics (Austin) (01-08-2012)“…In vertebrates, mitotic and meiotic M phase is facilitated by the kinase Greatwall (Gwl), which phosphorylates a conserved sequence in the effector Endosulfine…”
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Genetic Control of Kinetochore-Driven Microtubule Growth in Drosophila Mitosis
Published in Cells (Basel, Switzerland) (06-07-2022)“…Centrosome-containing cells assemble their spindles exploiting three main classes of microtubules (MTs): MTs nucleated by the centrosomes, MTs generated near…”
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Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference
Published in PLoS genetics (01-07-2008)“…RNAi screens have, to date, identified many genes required for mitotic divisions of Drosophila tissue culture cells. However, the inventory of such genes…”
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12
Feo, the Drosophila Homolog of PRC1, Is Required for Central-Spindle Formation and Cytokinesis
Published in Current biology (07-09-2004)“…We performed a functional analysis of fascetto (feo), a Drosophila gene that encodes a protein homologous to the Ase1p/PRC1/MAP65 conserved family of…”
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13
A signature inferred from Drosophila mitotic genes predicts survival of breast cancer patients
Published in PloS one (28-02-2011)“…The classification of breast cancer patients into risk groups provides a powerful tool for the identification of patients who will benefit from aggressive…”
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14
The role of Patronin in Drosophila mitosis
Published in BMC cell biology (17-04-2019)“…The calmodulin-regulated spectrin-associated proteins (CAMSAPs) belong to a conserved protein family, which includes members that bind the polymerizing…”
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15
Publisher Correction: The role of Patronin in Drosophila mitosis
Published in BMC cell biology (08-07-2019)“…During production of the original article [1], there was a technical error that resulted in author corrections not being rendered in the PDF version of the…”
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16
Chromosome Condensation Defects in barren RNA-Interfered Drosophila Cells
Published in Genetics (Austin) (01-11-2003)“…Barren, the Drosophila homolog of XCAP-H, is one of three non-SMC subunits of condensin, a conserved 13S multiprotein complex required for chromosome…”
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A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity
Published in Genetics (Austin) (01-03-2017)“…The protein phosphatase 2A (PP2A) is a conserved heterotrimeric enzyme that regulates several cellular processes including the DNA damage response and mitosis…”
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Drosophila Dgt6 Interacts with Ndc80, Msps/XMAP215, and γ-Tubulin to Promote Kinetochore-Driven MT Formation
Published in Current biology (17-11-2009)“…In centrosome-containing cells, spindle assembly relies on microtubules (MTs) nucleated from both centrosomes and chromosomes [1, 2]. Recent work has suggested…”
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Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells
Published in Molecular biology of the cell (01-07-2002)“…We have used double-stranded RNA-mediated interference (RNAi) to study Drosophila cytokinesis. We show that double-stranded RNAs for anillin, acGAP, pavarotti,…”
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Genetic Control of Kinetochore-Driven Microtubule Growth in IDrosophila/I Mitosis
Published in Cells (Basel, Switzerland) (06-07-2022)“…Centrosome-containing cells assemble their spindles exploiting three main classes of microtubules (MTs): MTs nucleated by the centrosomes, MTs generated near…”
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